Epithelial healing in experimental corneal alkali wounds with nondiluted autologous serum eye drops

Cutaneous and Ocular Toxicology

Volumn 29, Issue 2, 2010, Pages 116-121

  Salman, Ilknur Akyol ^a   Gündoǧdu, Cemal ^a  

^a ATATURK UNIVERSITY   (Turkey)

Author keywords

Alkali injury; Alkaline corneal epithelial wound healing; Autologous serum; Corneal wound healing

Indexed keywords

ALKALI; DEXAMETHASONE; EXOCIN; EYE DROPS; NONDILUTED AUTOLOGOUS SERUM EYE DROPS; OFLOXACIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA INJURY; EPITHELIUM HYPERPLASIA; EXPERIMENTAL RABBIT; FLUORESCENCE ANGIOGRAPHY; HISTOPATHOLOGY; NONHUMAN; SLIT LAMP; WOUND HEALING;

ALKALIES; ANIMALS; BURNS, CHEMICAL; CORNEA; EPITHELIUM, CORNEAL; EYE; EYE DISEASES; FLUORESCEIN; FLUORESCENT DYES; HYPERPLASIA; OPHTHALMIC SOLUTIONS; RABBITS; SERUM; WOUND HEALING;

ORYCTOLAGUS CUNICULUS;

EID: 77952204261     PISSN: 15569527     EISSN: 15569535     Source Type: Journal    
DOI: 10.3109/15569521003709558     Document Type: Article

References (42)

1. Pfister RR, Pfister DR. Alkali injuries of the eye. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. Philadelphia, PA: Elsevier Mosby. 2005:1285-1293.
2. Chung JH. Experimental corneal alkali wound healing. Acta Ophthalmol Suppl 1988; 187:4-35.
3. Kuckelkorn R, Schrage N, Keller G, Redbrake C. Emergency treatment of chemical and thermal eye burns. Acta Ophthalmol Scand 2002; 80(1):4-10.
4. Brodovsky SC, McCarty CA, Snibson G, Loughnan M, Sullivan L, Daniell M, et al. Management of alkali burns: an 11-year retrospective review. Ophthalmology 2000; 107:1829-1835.
5. Rozenbaum D, Baruchin AM, Dafna Z. Chemical burns of the eye with special reference to alkali burns. Burns 1991; 17:136-140.
6. Wagoner MD. Chemical injuries of the eye: current concepts in pathophysiology and therapy. Surv Ophthalmol 1997; 41:275-313.
7. Akyol-Salman I. Effects of autologous serum eye drops on corneal wound healing after superficial keratectomy in rabbits. Cornea 2006; 25:1178-1181.
8. Fox RI, Chan R, Michelson JB, Belmont JB, Michelson PE. Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum 1984; 27:459-461.
9. Tsubota K, Goto E, Shimmura S, Shimazaki J. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology 1999; 106:1984-1989.
10. Djalilian AR, Hamrah P, Pflugfelder SC. Dry eye. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. Philadelphia, PA: Elsevier Mosby; 2005:521-540.
11. Pflugfelder SC. Is autologous serum a tonic for the ailing corneal epithelium? Am J Ophthalmol 2006; 142: 316-317.
12. Geerling G, MacLennan S, Hartwig D. Autologous serum eye drops for ocular surface disorders. Br J Ophthalmol 2004; 88:1467-1474.
13. Matsumoto Y, Dogru M, Goto E, Ohashi Y, Kojima T, Ishida R, et al. Autologous serum application in the treatment of neurotrophic keratopathy. Ophthalmology 2004; 111:1115-1120.
14. Kojima T, Ishida R, Dogru M, Goto E, Matsumoto Y, Kaido M, et al. The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized casecontrol study. Am J Ophthalmol 2005; 139:242-246. (Pubitemid 40288267)
15. Poon AC, Geerling G, Dart JK, Fraenkel GE, Daniels JT. Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies. Br J Ophthalmol 2001; 85:1188-1197.
16. Ferreira de Souza R, Kruse FE, Seitz B. Autologous serum for otherwise therapy resistant corneal epithelial defects-prospective report on the first 70 eyes [in German]. Klin Monbl Augenheilkd 2001; 218:720-726.
17. Schulze SD, Sekundo W, Kroll P. Autologous serum for the treatment of corneal epithelial abrasions in diabetic patients undergoing vitrectomy. Am J Ophthalmol 2006; 142:207-211.
18. Shahriari HA, Tokhmehchi F, Reza M, Hashemi NF. Comparison of the effect of amniotic membrane suspension and autologous serum on alkaline corneal epithelial wound healing in the rabbit model. Cornea 2008; 27:1148-1150.
19. Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Geerling G. An optimised protocol for the production of autologous serum eyedrops. Graefes Arch Clin Exp Ophthalmol 2005; 243:706-714.
20. Mukerji N, Vajpayee RB, Sharma N. Technique of area measurement of epithelial defects. Cornea 2003; 22:549-551.
21. Risa O, Saether O, Midelfart A, Krane J, Cejková J. Analysis of immediate changes of water-soluble metabolites in alkali- burned rabbit cornea, aqueous humor and lens by highresolution 1H-NMR spectroscopy. Graefes Arch Clin Exp Ophthalmol 2002; 240:49-55.
22. Nishida T. Cornea. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. Philadelphia, PA: Elsevier Mosby; 2005:3-26.
23. Pepose JS, Ubels JL. The cornea. In: Hart WM, ed. Adler's Physiology of the Eye. St. Louis, MO: Mosby; 1992:29-63.
24. Kaufman HE, Baron BA, McDonald MB, Kaufman SC. Companion Handbook to the Cornea. Boston, MA: Butterworth-Heinemann; 2000.
25. Dua HS, Gomes JAP, Singh A. Corneal epithelial wound healing. Br J Ophthalmol 1994; 78:401-408.
26. Reim M. The results of ischaemia in chemical injuries. Eye 1992; 6:376-380.
27. Kaufman HE, Baron BA, McDonald MB, Kaufman SC. Corneal trauma. In: Kaufman HE, Baron BA, McDonald MB, Kaufman SC. eds. Companion Handbook to the Cornea. Boston, MA: Butterworth-Heinemann; 2000:599-641.
28. Cassell OC, Hofer SO, Morrison WA, Knight KR. Vascularisation of tissue-engineered grafts: the regulation of angiogenesis in reconstructive surgery and in disease states. Br J Plast Surg 2002; 55:603-610.
29. Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267:10931-10934.
30. Arnold F, West DC. Angiogenesis in wound healing. Pharmacol Ther 1991; 52:407-422.
31. Ramamurthi S, Rahman MQ, Dutton GN, Ramaesh K. Pathogenesis, clinical features and management of recurrent corneal erosions. Eye 2006; 20:635-644.
32. Higuchi A, Ueno R, Shimmura S, Suematsu M, Dogru M, Tsubota K. Albumin rescues ocular epithelial cells from cell death in dry eye. Curr Eye Res 2007; 32(2):83-88.
33. Berman M, Manseau E, Law M, Aiken D. Ulceration is correlated with degradation of fibrin and fibronectin at the corneal surface. Invest Ophthalmol Vis Sci 1983; 24:1358-1366.
34. Saika S, Kobata S, Hashizume N, Okada Y, Yamanaka O. Epithelial basement membrane in alkali-burned corneas in rats. Immunohistochemical study. Cornea 1993; 12:383-390.
35. Nishida T, Nakagawa S, Nishibayashi C, Tanaka H, Manabe R. Fibronectin enhancement of corneal epithelial wound healing of rabbits in vivo. Arch Ophthalmol 1984;102:455-456.
36. Phan TM, Foster CS, Boruchoff SA, Zagachin LM, Colvin RB. Topical fibronectin in the treatment of persistent corneal epithelial defects and trophic ulcers. Am J Ophthalmol 1987; 104:494-501.
37. Phan TM, Foster CS, Shaw CD, Zagachin LM, Colvin RB. Topical fibronectin in an alkali burn model of corneal ulceration in rabbits. Arch Ophthalmol 1991; 109: 414-419.
38. Brazzell RK, Stern ME, Aquavella JV, Beuerman RW, Baird L. Human recombinant epidermal growth factor in experimental corneal wound healing. Invest Ophthalmol Vis Sci 1991; 32:336-340.
39. Ho PC, Davis WH, Elliott JH, Cohen S. Kinetics of corneal epithelial regeneration and epidermal growth factor. Invest Ophthalmol 1974; 13:804-809.
40. Petroutsos G, Courty J, Guimaraes R, Petroutsos G, Courty J, Guimaraes R, et al. Comparison of the effects of EGF, pFGF and EDGF on corneal epithelium wound healing. Curr Eye Res 1984; 3:593-598.
41. Singh G, Foster CS. Epidermal growth factor in alkali-burned corneal epithelial wound healing. Am J Ophthalmol 1987; 103:802-807.
42. Schultz GS, Davis JB, Eiferman RA. Growth factors and corneal epithelium. Cornea 1988; 7:96-101.