Was the darwin/wedgwood dynasty adversely affected by consanguinity?

BioScience

Volumn 60, Issue 5, 2010, Pages 376-383

  Berra, Tim M ^a,b   Alvarez, Gonzalo ^c   Ceballos, Francisco C ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b MUSEUM AND ART GALLERY OF THE NORTHERN TERRITORY   (Australia)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Consanguineous marriage; Darwin; Inbreeding coefficient; Pedigrees; Wedgwood

Indexed keywords

EID: 77952191634     PISSN: 00063568     EISSN: None     Source Type: Journal    
DOI: 10.1525/bio.2010.60.5.7     Document Type: Article

References (47)

1. Adler S. 1959. Darwin's illness. Nature 184: 1102-1103.
2. Alvarez G, Ceballos FC, Quinteiro C. 2009. The role of inbreeding in the extinction of a European royal dynasty. PLoS ONE 4: e5174. doi:10.1371/journal. pone.0005174
3. Balloux F, Amos W, Coulson T. 2004. Does heterozygosity estimate inbreeding in real populations? Molecular Ecology 13: 3021-3031
4. Barlow N, ed. 1958. The Autobiography of Charles Darwin 1809-1882: With Original Omissions Restored. Collins.
5. Beers MH Berkow R. 1999. The Merck Manual of Diagnosis and Therapy. 17th ed. Merck Research Laboratories.
6. Bemiss SM. 1858. Report on influence of marriages of consanguinity upon offspring. Transactions of the American Medical Association 11: 319-425.
7. Bennett RL, et al. 2002. Genetic counseling and screening of consanguineous couples and their offspring: Recommendations of the National Society of Genetic Counselors. Journal of Genetic Counseling 11: 97-119.
8. Berra TM. 2009. Charles Darwin: The Concise Story of an Extraordinary Man. Johns Hopkins University Press.
9. Bittles AH, Black ML. 2009. Consanguinity, human evolution, and complex diseases. Proceedings of the National Academy of Sciences 107 (suppl. 1): 1779-1786.
10. Bittles AH, Neel JV. 1994. The costs of human inbreeding and their implications for variations at the DNA level. Nature Genetics 8: 117-121.
11. Bowlby J. 1990. Charles Darwin: A New Life. Norton.
12. Browne J. 1995. Charles Darwin: Voyaging. Knopf.
13. -. 2002. Charles Darwin: The Power of Place. Knopf
14. Burkhardt F, ed. 2008. Charles Darwin: The Beagle Letters. Cambridge University Press
15. Burkhardt F, Smith S, eds. 1990. The Correspondence of Charles Darwin, vol.6. Cambridge University Press.
16. -. 1991. The Correspondence of Charles Darwin, vol.7. Cambridge University Press.
17. Carothers AD, Rudan I, Kolcic I, Polasek O, Hayward C, Wright AF, Campbell H, Teague P, Hastie ND, Weber JL. Estimating human inbreeding coefficients: Comparisons of genealogical and marker heterozygosity approaches. Annals of Human Genetics 70: 666-676.
18. Cavalli-Sforza LL, Bodmer WF. 1971. The Genetics of Human Populations. Freeman.
19. Clift I. 2008. The Wedgwood/Darwin Dynasty. Melrose Books.
20. Colantonio SE, Lasker GW, Kaplan BA, Fuster V. 2003. Use of surname models in human population biology: A review of recent developments. Human Biology 75: 785-807.
21. Colp R. 2008. Darwin's Illness. University Press of Florida.
22. Darwin C. 1862. On the Various Contrivances by which British and Foreign Orchids are Fertilised by Insects and on the Good Effects of Intercrossing. John Murray.
23. -. 1868. The Variation of Animals and Plants under Domestication. John Murray.
24. -. 1876. The Effects of Cross and Self Fertilisation in the Vegetable Kingdom. John Murray.
25. -. 1877. The Different Forms of Flowers on Plants of the Same Species. John Murray.
26. Darwin GH. 1875. Marriages between first cousins in England and their effects. Journal of the Statistical Society 38: 153-184.
27. Desmond A, Moore J. 1991. Darwin: The Life of a Tormented Evolutionist. Warner Books.
28. Freeman RB. 1984. Darwin Pedigrees. Printed for Author. Geneall Project. 2009. Genealogical Information on European Countries. (26 February 2010; www.geneall.net)
29. Golubovsky M. 2008. Unexplained infertility in Charles Darwin's family: Genetic aspect. Human Reproduction 23: 1237-1238.
30. Hayman JA. 2009. Darwin's illness revisited. British Medical Journal 339: b4968: 1414-1415.
31. Healey E. 2001. Emma Darwin: The Inspirational Wife of a Genius. Headline.
32. Heiligman D. 2009. Charles and Emma: The Darwins' Leap of Faith. Holt.
33. Huether CA, Ivanovich J, Goodwin BS, Krivchenia EL, Hertzberg VS, Edmonds LD, May DS, Priest JH. 1998. Maternal age-specific risk rate estimates for Down syndrome among live births in white and other races from Ohio and metropolitan Atlanta, 1970-1989. Journal of Medical Genetics 35: 482-490.
34. Jones S. 2008. Darwin's Island: The Galapagos in the Garden of England. Little, Brown.
35. Keynes R. 2001. Annie's Box: Charles Darwin, His Daughter and Human Evolution. Fourth Estate.
36. King-Hele D, ed. 2003. Charles Darwin's "The Life of Erasmus Darwin." 1st ed. Cambridge University Press.
37. Laughlin HH. 1932. Historical Background of the Third International Congress of Eugenics in Scientific Papers of the Third International Congress of Eugenics held at the American Museum of Natural History New York, August 21-23, 1932: 1-14. Plate 7. A Decade of Progress in Eugenics. Williams and Wilkins.
38. Lyons EJ, Frodsham AJ, Zhang L, Hill AVS, Amos W. 2009a. Consanguinity and susceptibility to infectious diseases in humans. Biological Letters 5: 574-576.
39. Lyons EJ, et al. 2009b. Homozygosity and risk of childhood death due to invasive bacterial disease. BMC Medical Genetics 10: 55. doi:10.1186/1471-2350- 10-55.
40. Pannell JR. 2009. On the problems of a closed marriage: Celebrating Darwin 200. Biological Letters 5: 332-335.
41. Pearson K. 1914. The Life, Letters and Labours of Francis Galton, vol.1. Cambridge University Press.
42. -. 1930. The Life, Letters and Labours of Francis Galton, vol 3. Cambridge University Press.
43. Raverat G. 1952. Period Piece: A Cambridge Childhood. Faber.
44. Tobias PV. 1972. Darwin, "descent" and disease. Transactions of the Royal Society of South Africa 40: 239-260.
45. Williams N, Galley C. 1995. Urban-rural differentials in infant mortality in Victorian England. Population Studies 49: 401-420.
46. Woods CG, et al. 2006. Quantification of homozygosity in consanguineous individuals with autosomal recessive disease. American Journal of Human Genetics 78: 889-896.
47. Woods R. 2000. The Demography of Victorian England and Wales. Cambridge University Press.