Mild hypothermia reduces ischemic neuron death via altering the expression of p53 and bcl-2

Neurological Research

Volumn 32, Issue 4, 2010, Pages 384-389

  Zhang, Hong ^a   Xu, Guoying ^b   Zhang, Junjian ^a   Murong, Shenxing ^b   Mei, Yuanwu ^c   Tong, Etang ^c  

^a WUHAN UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bcl 2; Cerebral ischemia; Mild hypothermia; Neuron apoptosis; Neuron necrosis; P53

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY TEMPERATURE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN REGION; BRAIN TEMPERATURE; CONTROLLED STUDY; HIPPOCAMPUS; HISTOPATHOLOGY; HYPERTHERMIA; INDUCED HYPOTHERMIA; ISCHEMIA; MALE; MICROSCOPY; MORTALITY; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELL DEATH; CYTOPROTECTION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYPERTHERMIA, INDUCED; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; MALE; NECROSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TIME FACTORS; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77952128326     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164110X12670144526228     Document Type: Article

References (28)

1. Liu L, Yenari MA. Therapeutic hypothermia: Neuroprotective mechanisms. Front Biosci 2007; 12: 816-825
2. Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke: What do laboratory studies teach us? Stroke 2004; 35: 1482-1489
3. Phanithi PB, Yoshida Y, Santana A, et al. Mild hypothermia mitigates post-ischemic neuronal death following focal cerebral ischemia in rat brain: immunohistochemical study of Fas, caspase-and TUNEL. Neuropathology 2000; 20: 273-282.
4. Yenari MA, Iwayama S, Cheng D, et al. Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke. J Cereb Blood Flow Metab 2002; 22: 29-38
5. Zhang RL, Chopp M, Chen H, et al. Postischemic (1 hour) hypothermia significantly reduces ischemic cell damage in rats subjected to 2 hours of middle cerebral artery occlusion. Stroke 1993; 24: 1235-1240
6. Eberspächer E, Werner C, Engelhard K, et al. The effect of hypothermia on the expression of the apoptosis-regulating protein Bax after incomplete cerebral ischemia and reperfusion in rats. J Neurosurg Anesthesiol 2003; 15: 200-208
7. Eberspächer E, Werner C, Engelhard K, et al. Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in rats. Acta Anaesthesiologica Scandinavica 2005; 49: 477-487
8. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346: 557-563
9. Zhang H, Zhou M, Zhang J, et al. Therapeutic effect of postischemic hypothermia duration on cerebral ischemic injury. Neurol Res 2008; 30: 332-336
10. Zhang H, Zhou M, Zhang J, et al. Initiation time of post-ischemic hypothermia on the therapeutic effect in cerebral ischemic injury. Neurol Res 2009; 31: 336-339
11. Colbourne F, Li H, Buchan AM. Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J Cereb Blood Flow Metab 1999; 19: 742-749
12. Pulsinelli WA, Brierley JB. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 1979; 10: 267-272
13. Prakasa Babu P, Yoshida Y, Su M, et al. Immunohistochemical expression of Bcl-2, Bax and cytochrome c following focal cerebral iscbemia and effect of hypothermia in rat. Neurosci Lett 2000; 291: 196-200
14. Bian JY, Wang Z, Zhang SM, et al. Decompressive craniectomy and mild hypothermia reduces infarction size and counterregulates Bax and Bcl-2 expression after permanent focal ischemia in rats. Neurosurg Rev 2006; 29: 168-172
15. Harukuni I, Bhardwaj A. Mechanisms of brain injury after global cerebral ischemia. Neurol Clin 2006; 24: 1-21
16. Graham SH, Chen J. Programmed cell death in cerebral ischemia. J Cereb Blood Flow Metab 2001; 21: 99-109
17. van der Worp HB, van Gijn J. Clinical practice. Acute ischemic stroke. N Engl J Med 2007; 357: 572-579
18. Boysen G, Christensen H. Stroke severity determines body temperature in acute stroke. Stroke 2001; 32: 413-417
19. Zhao O, Memezawa H, Smith ML, et al. Hyperthermia complicates middle cerebral artery occlusion induced by an intraluminal filament. Brain Res 1994; 649: 253-259
20. Liu L, Yenari MA. Clinical application of therapeutic hypothermia in stroke. Neurol Res 2009; 31: 331-335
21. Schwab S, Georgiadis D, Berrouschot J, et al. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke 2001; 32: 2033-2035
22. Steiner T, Friede T, Aschoff A, et al. Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery. Stroke 2001; 32: 2833-2835
23. Jaramillo A, Illanes S, Díaz V. Is hypothermia useful in malignant ischemic stroke? Current status and future perspectives. J Neurol Sci 2008; 266: 1-8
24. Zhao H,Wang JQ, Shimohata T, et al. Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion. J Neurosurg 2007; 107: 636-641
25. van der Worp HB, Sena ES, Donnan GA, et al. Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis. Brain 2007; 130: 3063-3074
26. Minamisawa H, Smith ML, Siesjo BK. The effect of mild hyperthermia and hypothermia on brain damage following 5, 10 and 15 min of forebrain ischemia. Ann Neurol 1990; 28: 26-33
27. Ding Y, Li J, Luan X, et al. Local saline infusion into ischemic territory induces regional brain cooling and neuroprotection in rats with transient middle cerebral artery occlusion. Neurosurgery 2004; 54: 956-965
28. Perlman JM. Hyperthermia in the delivery: Potential impact on neonatal mortality and morbidity. Clin Perinatol 2006; 33: 55-63