Case report of long-term lithium for treatment and prevention of clozapine-induced neutropenia in an african american male

Journal of Clinical Psychopharmacology

Volumn 30, Issue 2, 2010, Pages 219-221

  Pinninti, Narsimha R ^a   Houdart, Michael P ^b   Strouse, Eileen McNeill ^c  

^a UMDNJ School of Osteopathic Medicine   (United States)

^b Hampton Behavioral Health Center   (United States)

^c Steininger Partial Care   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONAZEPAM; CLOZAPINE; LITHIUM CARBONATE; OLANZAPINE; TRAZODONE; VALPROIC ACID;

ADULT; AFRICAN AMERICAN; ALCOHOL ABUSE; BENIGN ETHNIC NEUTROPENIA; BIPOLAR DISORDER; CASE REPORT; DRUG BLOOD LEVEL; DRUG DOSE TITRATION; DRUG RECHALLENGE; DRUG WITHDRAWAL; HUMAN; IRRITABILITY; LABORATORY TEST; LETTER; LEUKOCYTE COUNT; LONG TERM CARE; LOW DRUG DOSE; MALE; MANIA; NEUTROPENIA; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS;

AFRICAN AMERICANS; CLOZAPINE; HUMANS; LITHIUM; MALE; NEUTROPENIA; TIME FACTORS; TREATMENT OUTCOME;

EID: 77952117804     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3181d47b74     Document Type: Letter

References (17)

1. 1. Kelly DL, Kreyenbuhl J, Dixon L, et al. Clozapine underutilization and discontinuation in African Americans due to leucopenia. Schizophr Bull. 2007;33:1221-1224. (Pubitemid 47347911)
2. Haddy TB, Rana SR, Castro O. Benign ethnic neutropenia: what is a normal absolute neutrophil count? J Lab Clin Med. 1999;133:15-22.
3. Mallinger JB, Lamberti JS. Clozapine-should race affect prescribing guidelines? Schizophr Res. 2006;83:107-108.
4. 4. Boshes RA, Manschreck TC, Desrosiers J, et al. Initiation of clozapine therapy in a patient with preexisting leukopenia: a discussion of the rationale of current treatment options. Ann Clin Psychiatry. 2002;13(4):233-237. (Pubitemid 34273563)
5. Clozapine prescribing information. Available at: http://www.pdr.net/ druginformation/FDAMonographsInfo.aspx?MonographID=929. Accessed June 15, 2009.
6. Gerson SL, Lieberman JA, Friedenberg WR, et al. Polypharmacy in fatal clozapine-associated agranulocytosis. Lancet. 1991;338:262-263.
7. Valevski A, Modai I, Lahav M, et al. Clozapine-lithium combined treatment and agranulocytosis. Int Clin Psychopharmacol. 1993;8:63-65.
8. Adityanjee. Modification of clozapine-induced leukopenia and neutropenia with lithium carbonate. Am J Psychiatry. 1995;152:648-649.
9. Blier P, Slater S, Measham T, et al. Lithium and clozapine-induced neutropenia/agranulocytosis. Int Clin Psychopharmacol. 1998;13:137-140.
10. Silverstone PH. Prevention of clozapine-induced neutropenia by pretreatment with lithium [letters to the editors]. J Clin Psychopharmacol. 1998;18:86-88.
11. Papetti F, Darcourt G, Giordana JY, et al. Treatment of clozapine-induced granulocytopenia with lithium (two observations). Encephale. 2004;30:578-582.
12. Kutscher EC, Robbins GP, Kennedy WK, et al. Clozapine-induced leukopenia successfully treated with lithium. Am J Health-System Pharm. 2007;64: 2027-2031.
13. 13. Ghaznavi S, Nakic M, Rao P, et al. Rechallenging with clozapine following neutropenia: treatment options for refractory schizophrenia [clinical case conference]. Am J Psychiatry. 2008;165:813-818. (Pubitemid 351948712)
14. 14. Bender S, Linka T, Wolstein J, et al. Safety and efficacy of combined clozapine-lithium pharmacotherapy. Int J Neuropsychopharmacol. 2004;7:59-63. (Pubitemid 38523808)
15. Kanaan RA, Kerwin RW. Lithium and clozapine rechallenge: a retrospective case analysis. J Clin Psychiatry. 2006;67:756-760.
16. 16. Sporn A, Gogtay N, Oritz AR, et al. Clozapine-induced neutropenia in children: management with lithium carbonate. J Child Adolesc Psychopharmacol. 2003;13:401-404. (Pubitemid 37288536)
17. 17. Sperner-Unterweger B, Czeipek I, Gaggl S, et al. Treatment of severe clozapine-induced neutropenia with granulocyte colony-stimulating factor (G-CSF): remission despite continuous treatment with clozapine. Br J Psychiatry. 1998;172:82-84. (Pubitemid 28122533)