Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 10, 2010, Pages 3047-3049

  Shen, Yongchun ^a   Du, Hong ^a   Kotake, Makoto ^b   Matsushima, Tomohiro ^b   Goto, Masaki ^b   Shirota, Hiroshi ^a   Gusovsky, Fabian ^a   Li, Xiangyi ^a   Jiang, Yimin ^a   Schiller, Shawn ^a   Spyvee, Mark ^a   Davis, Heather ^a   Zhang, Zhiyi ^a   Pelletier, Robert ^a   Ikemori Kawada, Megumi ^b   Kawakami, Yoshiyuki ^b   Inoue, Atsushi ^b   Wang, Yuan ^a  

^a EISAI INC   (United States)

^b EISAI CO LTD   (Japan)

Author keywords

Anti inflammatory; f152A1; LL Z1640 2; Resorcylic lactone

Indexed keywords

ER 803064; F 152A 1; LACTONE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; ORGANOLEAD COMPOUND; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATORY AGENTS; DRUG DISCOVERY; LACTONES; MAP KINASE KINASE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952112073     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.119     Document Type: Article

References (8)

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