Eukaryotic translation initiation factor 1 (eIF1), the inspector of good AUG context for translation initiation, has an extremely bad AUG context

Journal of Bioscience and Bioengineering

Volumn 109, Issue 6, 2010, Pages 635-637

  Miyasaka, Hitoshi ^a   Endo, Sumiyo ^b   Shimizu, Hiroyuki ^b  

^a KANSAI ELECTRIC POWER CO   (Japan)

^b TORAY RESEARCH CENTER INC   (Japan)

Author keywords

AUG context; eIF1; g value; Kozak sequence; Translation initiation

Indexed keywords

EFFECTIVE TRANSLATION; EUKARYOTIC TRANSLATION; G-VALUES; INITIATION FACTORS; NUCLEOTIDE SEQUENCES;

INITIATION FACTOR 1A;

AMINO ACID SEQUENCE; ARTICLE; CODON; DATA BASE; GENE DELETION; GENE INSERTION; GENE MUTATION; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; RNA STRUCTURE; SEQUENCE ANALYSIS; TRANSLATION INITIATION; UPREGULATION;

ANIMALS; BASE SEQUENCE; CODON, INITIATOR; EUKARYOTIC INITIATION FACTORS; HUMANS; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; PROTEIN BIOSYNTHESIS; RNA, MESSENGER;

EUKARYOTA;

EID: 77952110724     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2009.11.022     Document Type: Article

References (14)

1. Kozak M. Pushing the limits of the scanning mechanism for initiation of translation. Gene 299 (2002) 1-34
2. Kozak M. Regulation of translation via mRNA structure in prokaryotes and eukaryotes. Gene 361 (2005) 13-37
3. Miyasaka H. The positive relationship between codon usage bias and translation initiation AUG context in Saccharomyces cerevisiae. Yeast 15 (1999) 633-637
4. Miyasaka H. Translation initiation AUG context varies with codon usage bias and gene length in Drosophila melanogaster. J. Mol. Evol. 55 (2002) 52-64
5. Miyasaka H., Kanai S., Tanaka S., Akiyama H., and Hirano M. Statistical analysis of the relationship between translation initiation AUG context and gene expression level in humans. Biosci. Biotechnol. Biochem. 66 (2002) 667-669
6. Nakagawa S., Niimura Y., Gojobori T., Tanaka H., and Miura K. Diversity of preferred nucleotide sequences around the translation initiation codon in eukaryote genomes. Nucleic Acids Res. 36 (2007) 861-871
7. Mitchell S.F., and Lorsch J.R. Should I stay or should I go? Eukaryotic translation initiation factors 1 and 1A control start codon recognition. J. Biol. Chem. 283 (2008) 27345-27349
8. von der Haar T., and McCarthy J.E. Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function. Mol. Microbiol. 46 (2002) 531-544
9. Singh C.R., Udagawa T., Lee B., Wassink S., He H., Yamamoto Y., Anderson J.T., Pavitt G.D., and Asano K. Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo. J. Mol. Biol. 370 (2007) 315-330
10. Pisarev A.V., Kolupaeva V.G., Pisareva V.P., Merrick W.C., Hellen C.U., and Pestova T.V. Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex. Genes Dev. 20 (2006) 624-636
11. Pestova T.V., and Kolupaeva V.G. The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes Dev. 16 (2002) 2906-2922
12. Kozak M. Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo. Nature 308 (1984) 241-246
13. Wang X.Q., and Rothnagel J.A. 5′-Untranslated regions with multiple upstream AUG codons can support low-level translation via leaky scanning and reinitiation. Nucleic Acids Res. 32 (2004) 1382-1391
14. Kochetov A.V., Palyanov A., Titov I.I., Grigorovich D., Sarai A., and Kolchanov N.A. AUG_hairpin: prediction of a downstream secondary structure influencing the recognition of a translation start site. BMC Bioinformatics 8 (2007) 318-324