Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 19, 2010, Pages 1455-1465

  Else, Laura ^a   Watson, Victoria ^a,b   Tjia, John ^a   Hughes, Andrew ^b   Siccardi, Marco ^a   Khoo, Saye ^a   Back, David ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Etravirine; HPLC MS MS; Maraviroc; Protease inhibitors; Protein precipitation; Rilpivirine

Indexed keywords

ANALYTES; ANTIRETROVIRALS; CALIBRATION CURVES; CHROMATOGRAPHIC SEPARATIONS; CLINICAL PHARMACOKINETICS; CONCENTRATION RANGES; CORRELATION COEFFICIENT; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HPLC-MS/MS; INFECTED PATIENTS; INTERNAL STANDARDS; IONIZATION MODES; MOBILE PHASE; NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS; PHARMACOKINETIC DATA; PLASMA DRUG CONCENTRATION; PRECISE MEASUREMENTS; PROTEASE INHIBITOR; PROTEIN PRECIPITATION; RUNTIMES; SAQUINAVIR; SECOND GENERATION; SELECTIVE REACTION MONITORING; SIMULTANEOUS DETERMINATIONS; TRIPLE-QUADRUPOLE MASS SPECTROMETER;

ACETONITRILE; CENTRIFUGATION; CONCENTRATION (PROCESS); ENZYME INHIBITION; FORMIC ACID; IONIZATION OF LIQUIDS; MASS SPECTROMETRY; ORGANIC ACIDS; PHARMACOKINETICS; PROTEINS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETONITRILE; AMPRENAVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; DARUNAVIR; ETRAVIRINE; FORMIC ACID; LOPINAVIR; MARAVIROC; NEVIRAPINE; QUINOXALINE; RILPIVIRINE; RITONAVIR; SAQUINAVIR;

ARTICLE; CALIBRATION; CENTRIFUGATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; PRECIPITATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SUPERNATANT; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ANALYSIS OF VARIANCE; ANTI-HIV AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXANES; DRUG STABILITY; NITRILES; PYRIDAZINES; PYRIMIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TRIAZOLES;

EID: 77952108797     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.03.036     Document Type: Article

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