Mechanism underlying transient gestational-onset hypothyroidism-induced impairment of posttesticular sperm maturation in adult rats

Fertility and Sterility

Volumn 93, Issue 8, 2010, Pages 2491-2497

  Anbalagan, Jaganathan ^a   Sashi, Arokya Mary ^a   Vengatesh, Ganapathy ^a   Stanley, Jone Arulrajadurai ^a   Neelamohan, Ramalingam ^a   Aruldhas, Michael Mariajoseph ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Androgen receptor; dihydrotestoterone; epididymis; male fertility; sperm forward motility; testosterone; thyroid hormone

Indexed keywords

ANDROGEN RECEPTOR; CARNITINE; GLYCEROPHOSPHORYLCHOLINE; SIALIC ACID; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; THIAMAZOLE; THYROTROPIN;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CAUSAL ATTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDIDYMIS; GESTATION PERIOD; HYPOTHYROIDISM; LIGAND BINDING; MALE; MALE INFERTILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPERMATOZOON COUNT; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; THYROTROPIN BLOOD LEVEL;

ANIMALS; EPIDIDYMIS; FEMALE; HYPOTHYROIDISM; INFERTILITY, MALE; MALE; METHIMAZOLE; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; RNA, MESSENGER; SPERM MATURATION; SPERM MOTILITY; TESTIS; TESTOSTERONE 5-ALPHA-REDUCTASE; THYROID HORMONES;

EID: 77952101716     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2010.02.005     Document Type: Article

References (40)

1. Aruldhas MM. Thyroid and their mammalian testis-an update. In: Akbarsha MA, ed., Society for Reproductive Biology and Comparative Endocrinology, Chennai, India. Proceedings of the XX National Symposium of the Society for Reproductive Biology and Comparative Endocrinology, Bharathidasan University, Tiruchirapalli, India, January 7-9, 2002:15-18.
2. Jannini E.A., Ulisse S., and D'Armiento M. Thyroid hormone and male gonadal function. Endocr Rev 16 (1995) 443-459
3. Cooke P.S. Role of thyroid hormones in Sertoli cell mitogenesis and differentiation. Mol Endocrinol 7 (1995) 178-189
4. Maran R.R.M., Sivakumar R., Arunakaran J., Ravisankar B., Ravichandran K., Siddharthan V., et al. Duration-dependent effect of transient neonatal hypothyroidism on Sertoli and germ cell number, and plasma and testicular interstitial fluid androgen binding protein concentration. Endo Res 25 (1999) 323-340
5. Turner T.T. On the epididymis and its role in the development of the fertile ejaculate. J Androl 16 (1995) 292-298
6. Toshimori K. Biology of spermatozoa maturation: an overview with an introduction to this issue. Micro Res Tech 61 (2003) 1-6
7. Ezer N., and Robaire B. Androgenic regulation of the structure and function of the epididymis. In: Robaire B., and Hinton T. (Eds). The epididymis: from molecule to clinical practices (2002), Kluwer Academic/Plenum, New York 371-388
8. Dyson A.L., and Orgebin-Crist M.C. Effect of hypophysectomy, castration and androgen replacement upon the fertilizing ability of rat epididymal spermatozoa. Endocrinology 93 (1973) 391-402
9. Robaire B., and Fan X. Regulation of apoptotic cell death in the rat epididymis. J Reprod Fertil 53 (1998) 211-214
10. Aruldhas M.M., Valivullah H.M., and Govindarajulu P. Specific effect of the thyroid on testicular enzymes involved in carbohydrate metabolism I. Hypothyroidism. Int J Androl 5 (1982) 196-204
11. Aruldhas M.M., Valivullah H.M., and Govindarajulu P. Specific effect of the thyroid on testicular enzymes involved in carbohydrate metabolism II. Hyperthyroidism. Biochim Biophys Acta 715 (1982) 121-125
12. Aruldhas M.M., Valivullah H.M., and Govindarajulu P. Effect of thyroidectomy on testicular enzymes of the pyruvate/malate cycle involved in lipogenesis. Biochim Biophys Acta 755 (1983) 90-94
13. Aruldhas M.M., Valivullah H.M., and Govindarajulu P. Effect of thyroxine-induced hyperthyroidism on some testicular enzymes of the pyruvate/malate cycle. Biochem Biophys Acta 797 (1984) 143-146
14. Aruldhas M.M., Valivullah H.M., Srinivasan N., and Govindarajulu P. Role of thyroid on testicular lipids in prepubertal, pubertal and adult rats. I. Hyperthyroidism. Biochim Biophys Acta 881 (1986) 462-469
15. Hanna C.E., and LaFranchi S.H. Adolescent thyroid disorders. Adolescent Medicine 13 (2002) 13-36
16. Fisher D. The thyroid. In: Kaplan S. (Ed). Clinical pediatric endocrinology. 2nd ed. (1990), W.B. Saunders, Philadelphia 87-126
17. Maran M., and Aruldhas M.M. Adverse effects of neonatal hypothyroidism on Wistar rat spermatogenesis. Endocr Res 28 (2002) 141-154
18. Pereira B.M., Balasubramanian K., and Govindarajulu P. Thyroid-epididymal relationship. I. Influence of hypothyroidism on epididymal lipids. Biochim Biophys Acta 753 (1983) 300-305
19. Maran R.R., Priyadarsini D., Udhayakumar R.C., Arunakaran J., and Aruldhas M.M. Differential effect of hyperthyroidism on rat epididymal glycosidases. Int J Androl 24 (2001) 206-215
20. Kala N. Impact of foetal-onset hypothyroidism on the structure and functions of the epididymis in mature rats. Doctoral thesis, University of Madras, Chennai, India, 1998.
21. Kala N., Ravisankar B., Govindarajulu P., and Aruldhas M.M. Impact of foetal-onset hypothyroidism on the epididymis of mature rats. Int J Androl 25 (2002) 139-148
22. Marchant B., and Alexander W.D. The thyroid accumulation, oxidation and metabolic rate of 35 S-methimazole in rat. Endocrinology 91 (1972) 747-752
23. Aruldhas MM, Neelamohan R, Anbalagan J, Sashi AMJ, Stanley JA, Arumugam SN, et al. Gestational and neonatal-onset transient hypothyroidism evokes duration dependent specific changes in androgen receptor status in dorsolateral and ventral prostate glands of adult rats. Prostate. In press.
24. Banu S.K., Govindarajulu P., and Aruldhas M.M. Developmental profiles of TSH, sex steroids and their receptors in the thyroid and their relevance to thyroid growth in immature rats. Steroids 67 (2002) 137-144
25. Zaneveld L.J.D., and Polakoski K.L. Collection and physical examination of the ejaculate. In: Hafez E.S.E. (Ed). Amsterdam (1977), Biomedical Press, North Holland 147-156
26. Ratnasooriya W.D. Effect of atrophine on fertility of female rat and sperm motility. Ind J Exp Biol 22 (1984) 463-466
27. Warren L. The thiobarbituric acid assay of sialic acids. J Biol Chem 234 (1959) 1971-1975
28. Wirthenson G., and Guder W.G. Glycerophosphorylcholine. In: Bergmeyer H.V., and Grablas A. (Eds). Methods of enzymatic analysis. Metabolites 3 (1985), Verlag Chemie, Weinheim 112-117
29. Pearson D.J., Tubbs P.K., and Chase F.A. Carnitine and acetylcarnitine. In: Bergmeyer H.V., and Grablas A. (Eds). Methods of enzymatic analysis (1974), Verlag Chemie, Weinheim 1762-1767
30. Cooke P.S., Hess R.A., Porcelli J., and Meisami E. Increased sperm production in adult rats after transient neonatal hypothyroidism. Endocrinology 129 (1991) 244-248
31. Holdcraft R.W., and Braun R.E. Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development 131 (2004) 459-467
32. Sashi AMJ. Impact of gestational hypothyroidism on testicular development and differentiation in Wistar rats-an endocrine and histomorphometric study. Doctoral thesis, University of Madras, Chennai, India, 2007.
33. Viger R.S., and Robailre B. The mRNA for the steroid 5α reductase isozyme: type 1 and type 2, are differentially regulated in the rat epididymis. J Andol 17 (1996) 27-34
34. Sashi AMJ, Venkatesh NS, Vengatesh G, Sekhar P, Anbalagan J, Kala N, et al. Transient hypothyroidism during the second week of gestation has a temporal and region specific effect on the histoarchitecture of the epididymis at prepuberal, puberal and adult rats [abstract no. P-29]. Banaras Hindu University, Varanasi, India. In: XXI Symposium of the Society for Reproductive Biology and Comparative Endocrinology. Varanasi, India, February 10-13, 2003:100.
35. Rajalakshmi M., Arora R., Bose T.K., Dinakar N., Gupta G., Thampan T.N., et al. Physiology of the epididymis and induction of functional sterility in the male. J Reprod Fertil 24 (1976) 71-94
36. Amann R.P., Hammerstedt R.H., and Veeramachaneni D.R.N. The epididymis and sperm maturation: a perspective. Reprod Fertil Dev 5 (1993) 361-381
37. Prins G.S., and Woodham C. Autologous regulation of androgen receptor messenger ribonucleic acid in the separate lobes of the rat prostate gland. Biol Reprod 53 (1995) 609-616
38. Prins G. Differential regulation of androgen receptors in the separate rat prostate lobes: androgen independent expression in the lateral lobe. J Steroid Biochem 33 (1989) 319-326
39. Reiter E., Bonnet P., Sente B., Dombrowicz D., de Leval J., Closset J., et al. Growth hormone and prolactin stimulates androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats. Mol Cell Endocrinol 88 (1992) 77-87
40. Woodham C., Birch L., and Prins G.S. Neonatal estrogen down-regulates prostatic androgen receptor through a proteosome mediated protein degradation pathway. Endocrinology 144 (2003) 4841-4850