Insulin glargine and insulin have identical effects on proliferation and phosphatidylinositol 3-kinase/AKT signalling in rat thyrocytes and human follicular thyroid cancer cells

Diabetologia

Volumn 53, Issue 5, 2010, Pages 1001-1003

  Muller K ^a   Weidinger, C ^a   Fuhrer D ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Insulin glargine; Phosphatidylinositol 3 kinase AKT cascade; Proliferation; Thyroid cancer

Indexed keywords

BIM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INSULIN; INSULIN GLARGINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR FOXO;

ANIMAL CELL; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; LETTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; THYROID CANCER; THYROID CELL; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INSULIN; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYROID GLAND;

EID: 77952093575     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1674-3     Document Type: Letter

References (8)

1. M Stumvoll PP Nawroth 2009 The insulin glargine dilemma: an opportunity for the diabetes community? Diabetologia 52 1987 1989 10.1007/s00125-009-1490-9 1:STN:280:DC%2BD1Mngt1Kisw%3D%3D 19680625
2. JM Jonasson R Ljung M Talback B Haglund S Gudbjornsdottir G Steineck 2009 Insulin glargine use and short-term incidence of malignancies-a population-based follow-up study in Sweden Diabetologia 52 1745 1754 10.1007/s00125-009-1444-2 1:STN:280:DC%2BD1MrktlygtQ%3D%3D 19588120
3. A Shukla J Grisouard V Ehemann A Hermani H Enzmann D Mayer 2009 Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines Endocr Relat Cancer 16 429 441 10.1677/ERC-08-0240 1:CAS:528:DC%2BD1MXptlOht7c%3D 19153208
4. G Riesco-Eizaguirre P Santisteban 2007 Molecular biology of thyroid cancer initiation Clin Transl Oncol 9 686 693 10.1007/s12094-007-0125-1 1:CAS:528:DC%2BD1cXlslagtw%3D%3D 18055323
5. S Karger C Weidinger K Krause, et al. 2009 FOXO3a: a novel player in thyroid carcinogenesis? Endocr Relat Cancer 16 189 199 10.1677/ERC-07-0283 1:CAS:528:DC%2BD1MXptlOhsL8%3D 18845647
6. C Weidinger K Krause A Klagge S Karger D Fuhrer 2008 Forkhead box-O transcription factor: critical conductors of cancer's fate Endocr Relat Cancer 15 917 929 10.1677/ERC-08-0153 1:CAS:528:DC%2BD1MXitVyrsLw%3D 18775975
7. CJ Guigon L Zhao MC Willingham SY Cheng 2009 PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer Oncogene 28 509 517 10.1038/onc.2008.407 1:CAS:528:DC%2BD1MXhtFSls78%3D 18997818
8. LP Weng O Gimm JB Kum, et al. 2001 Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death Hum Mol Genet 10 251 258 10.1093/hmg/10.3.251 1:CAS:528: DC%2BD3MXht1Sktbc%3D 11159944 (Pubitemid 32123984)