Intra-arterial therapies for hepatocellular carcinoma: Where do we stand?

Annals of Surgical Oncology

Volumn 17, Issue 5, 2010, Pages 1234-1246

  Liapi, Eleni ^a   Geschwind, Jean Francois H ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CISPLATIN; DOXORUBICIN; IODINATED POPPYSEED OIL I 131; LIVER ENZYME; MITOMYCIN C; SORAFENIB; UNCLASSIFIED DRUG; YTTRIUM 90;

ABDOMINAL PAIN; ARTIFICIAL EMBOLISM; CANCER PATIENT; CANCER SURVIVAL; CHEMOEMBOLIZATION; CHOLECYSTITIS; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; EVIDENCE BASED MEDICINE; FATIGUE; HUMAN; INOPERABLE CANCER; INTERSTITIAL PNEUMONIA; LIVER CELL CARCINOMA; LIVER FAILURE; LYMPHOCYTOPENIA; META ANALYSIS; NAUSEA; OVERALL SURVIVAL; PAIN; REVIEW; SIDE EFFECT; SYSTEMATIC REVIEW; TREATMENT INDICATION; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; VOMITING;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CATHETER ABLATION; EMBOLIZATION, THERAPEUTIC; HUMANS; INFUSIONS, INTRA-ARTERIAL; LIVER NEOPLASMS; RADIOTHERAPY DOSAGE;

EID: 77952084899     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-010-0977-4     Document Type: Review

References (101)

1. JW Gyves HA Ziessman WD Ensminger, et al. 1984 Definition of hepatic tumor microcirculation by single photon emission computerized tomography (SPECT) J Nucl Med 25 972 977 1:STN:280:DyaL2c3ptFKktw%3D%3D 6088735 (Pubitemid 14033038)
2. HR Bierman RL Byron Jr KH Kelley A Grady 1951 Studies on the blood supply of tumors in man. III. Vascular patterns of the liver by hepatic arteriography in vivo J Natl Cancer Inst 12 107 131 1:STN:280:DyaG38%2FgsVagtw%3D%3D 14874125
3. JM Llovet AM Di Bisceglie J Bruix, et al. 2008 Design and endpoints of clinical trials in hepatocellular carcinoma J Natl Cancer Inst 100 698 711 10.1093/jnci/djn134 18477802
4. DE Ramsey LY Kernagis MC Soulen J-FH Geschwind 2002 Chemoembolization of hepatocellular carcinoma J Vasc Interv Radiol 13 21 211S 10.1016/S1051-0443(07) 61789-8
5. D Hanahan J Folkman 1996 Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell 86 353 364 10.1016/S0092-8674(00) 80108-7 1:CAS:528:DyaK28XltVSks7s%3D 8756718 (Pubitemid 26272076)
6. X Li GS Feng CS Zheng CK Zhuo X Liu 2004 Expression of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma and effect of transcatheter arterial chemoembolization therapy on plasma vascular endothelial growth factor level World J Gastroenterol 10 2878 2882 1:CAS:528:DC%2BD2cXovVWntLg%3D 15334691 (Pubitemid 39303010)
7. KW Kim SK Bae OH Lee, et al. 1998 Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma Cancer Res 58 348 351 1:CAS:528:DyaK1cXnt1ahtg%3D%3D 9443416 (Pubitemid 28047078)
8. XZ Wu GR Xie D Chen 2007 Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma J Gastroenterol Hepatol 22 1178 1182 10.1111/j.1440-1746.2007.04997.x 1:CAS:528:DC%2BD2sXpvFSnsrw%3D 17559361 (Pubitemid 47222667)
9. JT Erler KL Bennewith M Nicolau, et al. 2006 Lysyl oxidase is essential for hypoxia-induced metastasis Nature 440 7088 1222 1226 10.1038/nature04695 1:CAS:528:DC%2BD28XjvVGltb8%3D 16642001
10. J-FH Geschwind DE Ramsey BCH van der Wal, et al. 2003 Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency Cardiovasc Intervent Radiol 26 111 10.1007/s00270-002-2524-6 12616414 (Pubitemid 36919549)
11. DY Lin YF Liaw TY Lee CM Lai 1988 Hepatic arterial embolization in patients with unresectable hepatocellular carcinoma-a randomized controlled trial Gastroenterology 94 453 456 1:STN:280:DyaL1c%2FosVarsA%3D%3D 2826285
12. JM Llovet MI Real X Montana, et al. 2002 Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial Lancet 359 9319 1734 1739 10.1016/S0140-6736(02)08649-X 12049862 (Pubitemid 34607087)
13. T Rand C Loewe M Schoder MT Schmook, et al. 2005 Arterial embolization of unresectable hepatocellular carcinoma with use of microspheres, lipiodol, and cyanoacrylate Cardiovasc Intervent Radiol 28 313 318 10.1007/s00270-004-0153-y 15886943 (Pubitemid 40880750)
14. M Maluccio AM Covey R Gandhi, et al. 2005 Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm J Vasc Interv Radiol 16 955 961 16002503 (Pubitemid 40993518)
15. J Bruix JM Llovet A Castells, et al. 1998 Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: results of a randomized, controlled trial in a single institution Hepatology (Baltimore, Md) 27 1578 1583 1:STN:280:DyaK1c3otFKnsg%3D%3D (Pubitemid 28264682)
16. Marelli L, Stigliano R, Triantos C, et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol. 2007;30(1):6-25. (Pubitemid 44900485)
17. JM Chang WS Tzeng HB Pan CF Yang KH Lai 1994 Transcatheter arterial embolization with or without cisplatin treatment of hepatocellular carcinoma. A randomized controlled study Cancer 74 2449 2453 10.1002/1097-0142(19941101)74: 9<2449::AID-CNCR2820740910>3.0.CO;2-4 1:STN:280:DyaK2M%2FgslersA%3D%3D 7922999 (Pubitemid 24320847)
18. S Kawai J Okamura M Ogawa, et al. 1992 Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma-a comparison of lipiodol-transcatheter arterial embolization with and without adriamycin (first cooperative study) The Cooperative Study Group for Liver Cancer Treatment of Japan Cancer Chemother Pharmacol 31 Suppl S1 S6 10.1007/BF00687096 1281041
19. Malagari K, Pomoni M, Kelekis A, et al. Prospective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinoma. Cardiovasc Intervent Radiol. (in press), 24 Nov 2009 [Epub ahead of print].
20. MA Maluccio AM Covey LB Porat, et al. 2008 Transcatheter arterial embolization with only particles for the treatment of unresectable hepatocellular carcinoma J Vasc Interv Radiol 19 862 869 10.1016/j.jvir.2008.02. 013 18503900
21. Bonomo G, Pedicini V, Monfardini L, et al. Bland embolization in patients with unresectable hepatocellular carcinoma using precise, tightly size-calibrated, anti-inflammatory microparticles: First clinical experience and one-year follow-up. Cardiovasc Intervent Radiol. (in press), 3 Dec 2009 [Epub ahead of print].
22. AM Covey MA Maluccio J Schubert, et al. 2006 Particle embolization of recurrent hepatocellular carcinoma after hepatectomy Cancer 106 2181 2189 10.1002/cncr.21883 16596622 (Pubitemid 43673240)
23. R Yamada H Nakatsuka K Nakamura, et al. 1980 Hepatic artery embolization in 32 patients with unresectable hepatoma Osaka City Med J 26 81 96 1:STN:280:DyaL38%2Fjs1Oguw%3D%3D 6170035 (Pubitemid 11009683)
24. R Yamada M Sato M Kawabata, et al. 1983 Hepatic artery embolization in 120 patients with unresectable hepatoma Radiology 148 397 401 1:STN:280:DyaL3s3kvVWhsA%3D%3D 6306721 (Pubitemid 13073577)
25. K Nakakuma S Tashiro T Hiraoka, et al. 1983 Studies on anticancer treatment with an oily anticancer drug injected into the ligated feeding hepatic artery for liver cancer Cancer 52 2193 2200 10.1002/1097-0142(19831215)52: 12<2193::AID-CNCR2820521203>3.0.CO;2-R 1:STN:280:DyaL2c%2FlsV2ltA%3D%3D 6196102 (Pubitemid 14205933)
26. T Konno H Maeda K Iwai, et al. 1983 Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: A preliminary report Eur J Cancer Clin Oncol 19 1053 1065 10.1016/0277-5379(83)90028-7 1:STN:280:DyaL2c%2FgsVGgtw%3D%3D 6311559 (Pubitemid 13045311)
27. ME Clouse L Perry K Stuart KR Stokes 1994 Hepatic arterial chemoembolization for metastatic neuroendocrine tumors Digestion 55 Suppl 3 92 97 10.1159/000201208 7698544 (Pubitemid 24382174)
28. J Bruix M Sala JM Llovet 2004 Chemoembolization for hepatocellular carcinoma Gastroenterology 127 5 Suppl 1 S179 S188 10.1053/j.gastro.2004.09.032 1:CAS:528:DC%2BD2cXhtVGmtb%2FF 15508083 (Pubitemid 39423386)
29. N Terayama O Matsui T Gabata, et al. 2001 Accumulation of iodized oil within the nonneoplastic liver adjacent to hepatocellular carcinoma via the drainage routes of the tumor after transcatheter arterial embolization Cardiovasc Intervent Radiol 24 383 387 10.1007/s00270-001-0070-2 1:STN:280:DC%2BD387otVShtQ%3D%3D 11907744 (Pubitemid 34081419)
30. S Bhattacharya AP Dhillon MC Winslet, et al. 1996 Human liver cancer cells and endothelial cells incorporate iodised oil Br J Cancer 73 877 881 1:CAS:528:DyaK28XislKqs70%3D 8611399 (Pubitemid 26110156)
31. S Bhattacharya JR Novell MC Winslet KE Hobbs 1994 Iodized oil in the treatment of hepatocellular carcinoma Br J Surg 81 1563 1571 10.1002/bjs.1800811105 1:STN:280:DyaK2M7ivVKkuw%3D%3D 7827876 (Pubitemid 24349924)
32. Groupe d'Etude et de Traitement du Carcinome H. A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med. 1995;332:1256-61.
33. CM Lo H Ngan WK Tso, et al. 2002 Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma Hepatology 35 1164 1171 10.1053/jhep.2002.33156 1:CAS:528: DC%2BD38XktF2hu7w%3D 11981766 (Pubitemid 34454013)
34. T Aoki H Imamura K Hasegawa, et al. 2004 Sequential preoperative arterial and portal venous embolizations in patients with hepatocellular carcinoma Arch Surg 139 766 774 10.1001/archsurg.139.7.766 15249411 (Pubitemid 38886514)
35. JM Llovet A Burroughs J Bruix 2003 Hepatocellular carcinoma Lancet 362 9399 1907 1917 10.1016/S0140-6736(03)14964-1 14667750 (Pubitemid 37518510)
36. JM Llovet 2004 Treatment of hepatocellular carcinoma Curr Treat Options Gastroenterol 7 431 441 10.1007/s11938-004-0002-8 15527709
37. K Takayasu S Arii I Ikai, et al. 2006 Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients Gastroenterology 131 461 469 10.1053/j.gastro.2006.05.021 1:CAS:528:DC%2BD28XpsFyks7Y%3D 16890600 (Pubitemid 44142456)
38. T Livraghi F Meloni A Morabito C Vettori 2004 Multimodal image-guided tailored therapy of early and intermediate hepatocellular carcinoma: Long-term survival in the experience of a single radiologic referral center Liver Transpl 10 2 Suppl 1 S98 S106 10.1002/lt.20053 14762848 (Pubitemid 38240108)
39. CS Georgiades E Liapi C Frangakis, et al. 2006 Prognostic accuracy of 12 liver staging systems in patients with unresectable hepatocellular carcinoma treated with transarterial chemoembolization J Vasc Interv Radiol 17 1619 1624 10.1097/01.RVI.0000236608.91960.34 17057003 (Pubitemid 44581175)
40. E Liapi KH Lee CC Georgiades K Hong JF Geschwind 2007 Drug-eluting particles for interventional pharmacology Tech Vasc Interv Radiol 10 261 269 10.1053/j.tvir.2008.03.003 18572139 (Pubitemid 351902189)
41. E Liapi JF Geschwind 2007 Transcatheter and ablative therapeutic approaches for solid malignancies J Clin Oncol 25 978 986 10.1200/JCO.2006.09. 8657 17350947 (Pubitemid 350002864)
42. E Liapi CC Georgiades K Hong JF Geschwind 2007 Transcatheter arterial chemoembolization: Current technique and future promise Tech Vasc Interv Radiol 10 2 11 10.1053/j.tvir.2007.08.008 17980314 (Pubitemid 350008078)
43. IR Kamel E Liapi DK Reyes, et al. 2009 Unresectable hepatocellular carcinoma: Serial early vascular and cellular changes after transarterial chemoembolization as detected with MR imaging Radiology 250 466 473 10.1148/radiol.2502072222 19188315
44. K Hong E Liapi CS Georgiades JF Geschwind 2005 Case-controlled comparison of a percutaneous collagen arteriotomy closure device versus manual compression after liver chemoembolization J Vasc Interv Radiol 16 339 345 1:CAS:528:DC%2BD2MXhtVKqtrzM 15758129 (Pubitemid 40354850)
45. CS Georgiades K Hong M D'Angelo JF Geschwind 2005 Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis J Vasc Interv Radiol 16 1653 1659 16371532 (Pubitemid 44431162)
46. E de Luis J Bilbao J de Ciércoles, et al. 2008 In vivo evaluation of a new embolic spherical particle (HepaSphere) in a kidney animal model Cardiovasc Intervent Radiol 31 367 376 10.1007/s00270-007-9240-1 18167024
47. RT Poon WK Tso RW Pang, et al. 2007 A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead Clin Gastroenterol Hepatol 5 1100 1108 10.1016/j.cgh.2007.04. 021 1:CAS:528:DC%2BD2sXhtFKrt7%2FE 17627902
48. M Constantin G Fundueanu F Bortolotti, et al. 2004 Preparation and characterisation of poly(vinyl alcohol)/cyclodextrin microspheres as matrix for inclusion and separation of drugs Int J Pharmaceutics 285 87 96 10.1016/j.ijpharm.2004.07.025 1:CAS:528:DC%2BD2cXosFSrsbw%3D (Pubitemid 39361539)
49. M Varela MI Real M Burrel, et al. 2007 Chemoembolization of hepatocellular carcinoma with drug eluting beads: Efficacy and doxorubicin pharmacokinetics J Hepatol 46 474 481 10.1016/j.jhep.2006.10.020 1:CAS:528:DC%2BD2sXhtlCmtb0%3D 17239480 (Pubitemid 46201723)
50. K Malagari K Chatzimichael E Alexopoulou, et al. 2008 Transarterial chemoembolization of unresectable hepatocellular carcinoma with drug eluting beads: results of an open-label study of 62 patients Cardiovasc Intervent Radiol 31 269 280 10.1007/s00270-007-9226-z 17999110
51. Vossen JA, Reyes DK, Kamel IR, et al. Single centre phase II trial of transarterial chemoembolization with drug eluting beads for patients with unresectable hepatocellular carcinoma: Initial experience in the USA. Presented at: CIRSE; Lisbon, Portugal; 2009.
52. Reyes DK, Geschwind JF, Wahlin T, et al. Intraarterial doxorubicin-eluting microspheres for patients with unresectable hepatocellular carcinoma: A pilot study. Presented at: CIRSE; Athens, Greece; 2007.
53. J Lammer K Malagari T Vogl, et al. 2010 Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study Cardiovasc Intervent Radiol 33 41 52 10.1007/s00270-009-9711-7 19908093
54. Massa Saluzzo C, Vignali C, Nicolini A, et al. TACE with HepaSphere microspheres loaded with chemotherapeutic agent: Early experience in Italy of a multi-centre study. Presented at: World Conference in Interventional Oncology (WCIO); Washington, DC; 2007.
55. BY Ha A Ahmed DY Sze, et al. 2007 Long-term survival of patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoinfusion Aliment Pharmacol Ther 26 839 846 1:STN:280:DC%2BD2srhslSiuw%3D%3D 17767468 (Pubitemid 47346701)
56. Kim P, Prapong W, Sze DY, So SK, Razavi MK. Treatment of hepatocellular carcinoma with sub-selective transcatheter arterial oily chemoinfusion. Tech Vasc Interv Radiol. 2002;5(3):127-31. (Pubitemid 36078168)
57. JH Kim HK Yoon SY Kim, et al. 2009 Transcatheter arterial chemoembolization vs. chemoinfusion for unresectable hepatocellular carcinoma in patients with major portal vein thrombosis Aliment Pharmacol Ther 29 1291 1298 10.1111/j.1365-2036.2009.04016.x 1:STN:280:DC%2BD1MzntVGltQ%3D%3D 19392861
58. W De Luna DY Sze A Ahmed, et al. 2009 Transarterial chemoinfusion for hepatocellular carcinoma as downstaging therapy and a bridge toward liver transplantation Am J Transplant 9 1158 1168 10.1111/j.1600-6143.2009.02576.x 19344435
59. 90Y-microspheres J Nucl Med 41 1673 1681 1:STN:280:DC%2BD3cvoslOguw%3D%3D 11037997
60. LA Dawson 2005 Hepatic arterial yttrium 90 microspheres: Another treatment option for hepatocellular carcinoma J Vasc Interv Radiol 16 161 164 15713916
61. AS Kennedy C Nutting D Coldwell J Gaiser C Drachenberg 2004 Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers Int J Radiat Oncol Biol Phys 60 1552 1563 1:CAS:528:DC%2BD2cXhtVKrtLzO 15590187 (Pubitemid 39601873)
62. ED Yorke A Jackson RA Fox BW Wessels BN Gray 1999 Can current models explain the lack of liver complications in Y-90 microsphere therapy? Clin Cancer Res 5 10 Suppl 3024s 3030s 1:STN:280:DC%2BD3c%2FgslemsA%3D%3D 10541339 (Pubitemid 29493891)
63. LA Dawson CJ McGinn D Normolle, et al. 2000 Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies J Clin Oncol 18 2210 2218 1:CAS:528: DC%2BD3cXktlagsb4%3D 10829040 (Pubitemid 30350212)
64. LA Dawson CJ McGinn TS Lawrence 2003 Conformal chemoradiation for primary and metastatic liver malignancies Semin Surg Oncol 21 249 255 10.1002/ssu.10043 14648782 (Pubitemid 37521722)
65. IM Ariel 1965 Treatment of inoperable primary pancreatic and liver cancer by the intra-arterial administration of radioactive isotopes (Y90 radiating microspheres) Ann Surg 162 267 278 10.1097/00000658-196508000-00018 1:STN:280:DyaF2M7jtFKqsg%3D%3D 14327011
66. IM Ariel GT Pack 1967 Treatment of inoperable cancer of the liver by intra-arterial radioactive isotopes and chemotherapy Cancer 20 793 804 10.1002/1097-0142(1967)20:5<793::AID-CNCR2820200534>3.0.CO;2-I 1:STN:280:DyaF2s7jvVajtg%3D%3D 6024291
67. RJ Blanchard I Grotenhuis JW Lafave CW Frye JF Perry Jr 1964 Treatment of experimental tumors; utilization of radioactive microspheres Arch Surg 89 406 410 1:STN:280:DyaF2c7hvVWnsw%3D%3D 14160169
68. TR Nolan ED Grady 1969 Intravascular particulate radioisotope therapy: Clinical observations of 76 patients with advanced cancer treated with 90-yttrium particles Am Surgeon 35 181 188 1:STN:280:DyaF1M7lt12rtw%3D%3D 5776876
69. WY Lau S Ho WT Leung, et al. 2001 What determines survival duration in hepatocellular carcinoma treated with intraarterial yttrium-90 microspheres? Hepatogastroenterology 48 338 340 1:CAS:528:DC%2BD3MXjs1ehu70%3D 11379304 (Pubitemid 32391562)
70. 90yttrium glass microspheres (Therasphere) for unresectable hepatocellular carcinoma: Interim safety and survival data on 65 patients Liver Transpl 10 2 Suppl 1 S107 S110 10.1002/lt.20036 14762849
71. JF Geschwind R Salem BI Carr, et al. 2004 Yttrium-90 microspheres for the treatment of hepatocellular carcinoma Gastroenterology 127 5 Suppl 1 S194 S205 10.1053/j.gastro.2004.09.034 1:CAS:528:DC%2BD2cXhtVGmtbzN 15508085 (Pubitemid 39423388)
72. MJ Herba MP Thirlwell 2002 Radioembolization for hepatic metastases Semin Oncol 29 152 159 10.1053/sonc.2002.31672 11951213 (Pubitemid 34297286)
73. MJ Herba FF Illescas MP Thirlwell, et al. 1988 Hepatic malignancies: Improved treatment with intraarterial Y-90 Radiology 169 311 314 1:STN:280:DyaL1M%2Fhslymtg%3D%3D 3174978
74. JC Andrews SC Walker RJ Ackermann, et al. 1994 Hepatic radioembolization with yttrium-90 containing glass microspheres: Preliminary results and clinical follow-up J Nucl Med 35 1637 1644 1:STN:280:DyaK2M%2FhslSqsQ%3D%3D 7931662
75. Campbell AM, Bailey IH, Burton MA. Analysis of the distribution of intra-arterial microspheres in human liver following hepatic yttrium-90 microsphere therapy. Phys Med Biol. 2000:1023-33.
76. R Salem RJ Lewandowski MF Mulcahy, et al. 2010 Radioembolization for hepatocellular carcinoma using yttrium-90 microspheres: A comprehensive report of long-term outcomes Gastroenterology 138 52 64 10.1053/j.gastro.2009.09.006 1:CAS:528:DC%2BC3cXht1ajsLY%3D 19766639
77. Goin JE, Salem R, Carr BI, et al. Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: A risk-stratification analysis. J Vasc Interv Radiol. 2005;16(2 Pt 1):195-203. (Pubitemid 40322292)
78. 18F]fluorodeoxyglucose positron emission tomography and computed tomographic imaging J Vasc Interv Radiol 16 1641 1651 16371530
79. 90Y microspheres (TheraSphere): Safety, tumor response, and survival J Vasc Interv Radiol 16 1627 1639 16371529 (Pubitemid 44431160)
80. LM Kulik B Atassi L van Holsbeeck, et al. 2006 Yttrium-90 microspheres (TheraSphere(R)) treatment of unresectable hepatocellular carcinoma: Downstaging to resection, RFA and bridge to transplantation J Surg Oncol 94 572 586 10.1002/jso.20609 1:CAS:528:DC%2BD28XhtlCisb3P 17048240 (Pubitemid 44851918)
81. LM Kulik MF Mulcahy RD Hunter, et al. 2005 Use of yttrium-90 microspheres (TheraSphere) in a patient with unresectable hepatocellular carcinoma leading to liver transplantation: A case report Liver Transpl 11 1127 1131 10.1002/lt.20514 16123954 (Pubitemid 41341764)
82. T Tancredi PA McCuskey Z Kan S Wallace 1999 Changes in rat liver microcirculation after experimental hepatic arterial embolization: Comparison of different embolic agents Radiology 211 177 181 1:STN:280:DyaK1M3gsFCltA%3D%3D 10189468 (Pubitemid 29161748)
83. JF Geschwind D Artemov S Abraham, et al. 2000 Chemoembolization of liver tumor in a rabbit model: Assessment of tumor cell death with diffusion-weighted MR imaging and histologic analysis J Vasc Interv Radiol 11 1245 1255 10.1016/S1051-0443(07)61299-8 1:STN:280:DC%2BD3Mzgs1ehtw%3D%3D 11099235
84. 131I-labeled lipiodol after resection of hepatocellular carcinoma: Progress report of a case-control study with a 5-year minimal follow-up J Nucl Med 49 362 366 10.2967/jnumed.107.044750 18287267 (Pubitemid 351355200)
85. 131I-labelled- iodized oil for palliative treatment of hepatocellular carcinoma Eur J Gastroenterol Hepatol 17 905 910 10.1097/00042737-200509000-00004 1:CAS:528:DC%2BD2MXnt1yktLc%3D 16093866 (Pubitemid 41192127)
86. BI Carr 2004 Hepatocellular carcinoma: Current management and future trends Gastroenterology 127 S218 10.1053/j.gastro.2004.09.036 15508087 (Pubitemid 39423390)
87. R Salem KG Thurston BI Carr JE Goin JF Geschwind 2002 Yttrium-90 microspheres: radiation therapy for unresectable liver cancer J Vasc Interv Radiol 13 9 Pt 2 S223 S229 10.1016/S1051-0443(07)61790-4 12354840
88. V Foubister 2002 Energy blocker to treat liver cancer Drug Discovery Today 7 934 10.1016/S1359-6446(02)02449-2 12546860 (Pubitemid 35286891)
89. T Reid E Galanis J Abbruzzese, et al. 2002 Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints Cancer Res 62 6070 6079 1:CAS:528: DC%2BD38XosF2msr0%3D 12414631 (Pubitemid 35244455)
90. T Reid E Galanis J Abbruzzese, et al. 2001 Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: A phase I trial Gene Ther 8 1618 1626 10.1038/sj.gt.3301512 1:CAS:528:DC%2BD3MXosVyqurs%3D 11895000 (Pubitemid 33085583)
91. W Yang MH Chen MQ Wang, et al. 2009 Combination therapy of radiofrequency ablation and transarterial chemoembolization in recurrent hepatocellular carcinoma after hepatectomy compared with single treatment Hepatol Res 39 231 240 10.1111/j.1872-034X.2008.00451.x 1:CAS:528:DC%2BD1MXktlKqsrw%3D 19054154
92. Reyes DK, Vossen JA, Kamel IR, et al. Phase II trial of bevacizumab combined with transarterial chemoembolization (TACE) for hepatocellular carcinoma: Initial experience at two institutions. ASCO 2010 Gastrointestinal Cancers Symposium, Orlando, FL; 2010.
93. C Camma F Schepis A Orlando, et al. 2002 Transarterial chemoembolization for unresectable hepatocellular carcinoma: Meta-analysis of randomized controlled trials Radiology 224 47 54 10.1148/radiol.2241011262 12091661 (Pubitemid 34680374)
94. MF Yuen AOO Chan BCY Wong, et al. 2003 Transarterial chemoembolization for inoperable, early stage hepatocellular carcinoma in patients with Child-Pugh grade A and B: results of a comparative study in 96 Chinese patients Am J Gastroenterol 98 1181 1185 12809846
95. DB Brown WC Chapman RD Cook, et al. 2008 Chemoembolization of hepatocellular carcinoma: Patient status at presentation and outcome over 15 years at a single center Am J Roentgenol 190 608 615 10.2214/AJR.07.2879 (Pubitemid 351304502)
96. Liapi E, Lee KH, Hong K, et al. Chemoembolization of hepatocellular carcinoma with a standardized treatment and follow-up protocol: Survival, clinical, and tumor control outcome over 11 years at a single center. Presented at: 94th Scientific Assembly and Meeting, Radiologic Society of North America; Chicago, IL; 2008.
97. K Malagari E Alexopoulou K Chatzimichail, et al. 2008 Transcatheter chemoembolization in the treatment of HCC in patients not eligible for curative treatments: Midterm results of doxorubicin-loaded DC bead Abdom Imaging 33 512 519 10.1007/s00261-007-9334-x 17938995
98. A Forner C Ayuso M Varela, et al. 2009 Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma Cancer 115 616 623 10.1002/cncr.24050 19117042
99. J Kettenbach A Stadler IV Katzler, et al. 2008 Drug-loaded microspheres for the treatment of liver cancer: review of current results Cardiovasc Intervent Radiol 31 468 476 10.1007/s00270-007-9280-6 18228095
100. 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis Hepatology 47 71 81 10.1002/hep.21980 18027884 (Pubitemid 351171043)
101. Grosso M, Vignali C, Quaretti P, et al. Transarterial chemoembolization for hepatocellular carcinoma with drug-eluting microspheres: Preliminary results from an Italian multicentre study. Cardiovasc Intervent Radiol. 2008;31(6):1141-9.