Paraoxon down regulates ATP-binding Cassette Transporter A1 expression and decreases cholesterol efflux through cyclic AMP signaling pathway in RAW 264.7 macrophage-derived foam cells

Progress in Biochemistry and Biophysics

Volumn 37, Issue 2, 2010, Pages 190-199

  Zhou, Shou Hong ^a,b   Yang, Xu Hong ^a   Wu, Shu Jin ^a   Chen, Geng Rong ^a   Liu, Li Ying ^a  

^a Central South University   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

ABCA1; Atherosclerosis; CAMP; Paraoxon; Reverse cholesterol transport

Indexed keywords

EID: 77952016609     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2009.00476     Document Type: Article

References (32)

1. Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation, 2005, 111(25): 3481-3488
2. Babaev V R, Gleaves L A, Carter K J, et al. Reduced atherosclerotic lesions in mice deficient for total ormacrophage-specific expression of scavenger receptor-A. Arterioscler Thomb Vase Biol, 2000, 20(12): 2593-2599
3. Marcel Y L, Ouimet M, Wang M D. Regulation of cholesterol efflux from macrophages. Curr Opin Lipidol, 2008, 19(5): 455-461
4. Aiello R J, Brees D, Francone O L. ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation. Arterioscler Thromb Vase Biol, 2003, 23 (6): 972-980 (Pubitemid 36713549)
5. Hozoji M, Munehira Y, Ikeda Y, et al. Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux. J Biol Chem, 2008, 283(44): 30057-30063
6. Haidar B, Denis M, Krimbou L, et al. cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts. J Lipid Res, 2002, 43(12): 2087-2094 (Pubitemid 35471076)
7. Bortnick A E, Rothblat G H, Stoudt G, et al. The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines. J Biol Chem, 2000, 275(37): 28634-28640
8. Hu Y W, Ma X, Li X X, et al. Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells. Atherosclerosis, 2009, 204(2): 35-43
9. Foxenberg R J, McGarrigle B P, Knaak J B, et al. Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos. Drug Metab Dispos, 2007, 35(2): 189-193
10. Crow J A, Middleton B L, Borazjani A, et al. Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages. Biochim Biophys Acta, 2008, 1781(10): 643-654
11. Weibel G L, Joshi M R, Alexander E T, et al. Overexpression of human 15 (S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport. Arterioscler Thromb Vase Biol, 2009, 29(6): 837-842
12. Boo Y C, Hwang J, Sykes M, et al. Shear stress stimulates phosphorylation of eNOS at Ser (635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol, 2002, 283(5): 1819-1828
13. Hanson M S, Stephenson A H, Bowles E A, et al. Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP. Am J Physiol Heart Circ Physiol, 2008, 295(2): 786-793
14. Hao X R, Cao D L, Hu Y W, et al. IFN-gamma down-regulates ABCA1 expression by inhibiting LXR-alpha in a JAK/STAT signaling pathway-dependent manner. Atherosclerosis, 2009, 203(2): 417-428
15. Tang C K, Yi G H, Wang Z, et al. Prog Biochem Biophys, 2004, 31(2): 127-133
16. Oram J F, Lawn R M, Garvin M R, et al. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J Biol Chem, 2000, 275 (44): 34508-34511
17. Chiavegatti T, Costa V J, Araújo M S, et al. Skeletal muscle expresses the extracellular cyclic AMP-adenosine pathway. Br J Pharmacol, 2008, 153(6): 1331-1340 (Pubitemid 351415496)
18. Lewis G F, Rader D J. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res, 2005, 96(12): 1221-1232 (Pubitemid 40962099)
19. Tall A R, Costet P, Wang N. Regulation and mechanisms of macrophage cholesterol efflux. J Clin Invest, 2002, 110 (7): 899-904
20. Brewer H B J, Remaley A T, Neufeld E B, et al. Regulation of plasma high-density lipoprotein levels by the ABCA1 transporter and the emerging role of high-density lipoprotein in the treatment of cardiovascular disease. Arterioscler Thromb Vase Biol, 2004, 24(10): 1755-1760
21. EckardsteinAV,HersbergerM,RohrerL. CurrentunderstandingofthemetabolismandbiologicalactionsofHDL. CurrOpinClinNutrMetabCare,2005,8(2):147-152(Pubitemid40289474)
22. Oram J F. ATP-binding cassette transporter Al and cholesterol trafficking. Curr Opin Lipidol, 2002, 13(4): 373-381
23. Francone O L, Aiello R J. ABCAl: regulation, function and relationship to atherosclerosis. Curr Opin Invest Drugs, 2002, 3(3): 415-419
24. Tang C K, He X S, Yi G H, et al. Prog Biochem Biophys, 2003, 30(6): 940-944
25. Olivier K J, Liu J, Pope C, et al. Inhibition of forskolin-stimulated cAMP formation in vitro by paraoxon and chlorpyrifos oxon in cortical slices from neonatal, juvenile, and adult rats. J Biochem Mol Toxicol, 2001, 15(5): 263-269
26. Svoboda N, Zierler S, Kerschbaum H H. cAMP mediates ammoniainduced programmed cell death in the microglial cell line BV-2. Eur J Neurosci, 2007, 25(8): 2285-2295 (Pubitemid 46625909)
27. Adderley S P, Dufaux E A, Shridharan M, et al. Iloprost-and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans. Am J Physiol Heart Circ Physiol, 2009, 296(5): 1617-1624
28. Huff R A, Corcoran J J, Anderson J K, et al. Chlorpyrifos oxon binds directly to muscarinic receptorsand inhibits cAMP accumulation in rat striatum. J Pharmacol Exp Ther, 1994, 269(1): 329-335
29. 4 receptors in rat frontal cortex. Brain Res Bull, 1996, 39(1): 49-55
30. Lin G, Bornfeldt K E. Cyclic AMP-specific phosphodiesterase 4 inhibitors promote ABCA1 expression and cholesterol efflux. Biochem Biophys Res Commun, 2002, 290(2): 663-669 (Pubitemid 34687491)
31. Brook R D, Franklin B, Caseio W, et al. Air pollution and cardiovascular disease. Circulation, 2004, 109(21): 2655-2671
32. Andreassi M G. Metabolic syndrome, diabetes and atherosclerosis: Influence of gene-environment interaction. Mutat Res, 2009, 667 (1-2): 35-43