AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive t cells

Molecular Therapy

Volumn 18, Issue 5, 2010, Pages 977-982

  Somanathan, Suryanarayan ^a   Breous, Ekaterina ^a   Bell, Peter ^a   Wilson, James M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CPG OLIGODEOXYNUCLEOTIDE; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PARVOVIRUS VECTOR; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; LIVER CELL; MALE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BETA-GALACTOSIDASE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DEPENDOVIRUS; GENES, MHC CLASS I; GENETIC VECTORS; HEPATOCYTES; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OLIGODEOXYRIBONUCLEOTIDES; POLYMERASE CHAIN REACTION; TRANSDUCTION, GENETIC; VASCULAR CELL ADHESION MOLECULE-1;

ADENO-ASSOCIATED VIRUS; MUS;

EID: 77952010442     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.40     Document Type: Article

References (23)

1. Yang, Y, Jooss, KU, Su, Q, Ertl, HC and Wilson, JM (1996). Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther 3:137-144.
2. Jooss, K, Yang, Y, Fisher, KJ and Wilson, JM (1998). Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers. J Virol 72:4212-4223.
3. Mays, LE, Vandenberghe, LH, Xiao, R, Bell, P, Nam, HJ, Agbandje-McKenna, M et al. (2009). Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins. J Immunol 182:6051-6060.
4. Snyder, RO, Miao, C, Meuse, L, Tubb, J, Donahue, BA, Lin, HF et al. (1999). Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors. Nat Med 5:64-70.
5. Dobrzynski, E, Mingozzi, F, Liu, YL, Bendo, E, Cao, O, Wang, L et al. (2004). Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transfer. Blood 104:969-977.
6. Dobrzynski, E, Fitzgerald, JC, Cao, O, Mingozzi, F, Wang, L and Herzog, RW (2006). Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells. Proc Natl Acad Sci USA 103:4592-4597.
7. Martino, AT, Nayak, S, Hoffman, BE, Cooper, M, Liao, G, Markusic, DM et al. (2009). Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity. PLoS ONE 4: e6376.
8. Breous, E, Somanathan, S, Vandenberghe, LH and Wilson, JM (2009). Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver. Hepatology 50:612-621.
9. Gao, G, Wang, Q, Calcedo, R, Mays, L, Bell, P, Wang, L et al. (2009). Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses. Hum Gene Ther 20:930-942.
10. Wang, L, Calcedo, R, Wang, H, Bell, P, Grant, R, Vandenberghe, LH et al. (2010). The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques. Mol Ther 18:126-134.
11. Yang, Y, Xiang, Z, Ertl, HC and Wilson, JM (1995). Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc Natl Acad Sci USA 92:7257-7261.
12. Lang, KS, Georgiev, P, Recher, M, Navarini, AA, Bergthaler, A, Heikenwalder, M et al. (2006). Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling. J Clin Invest 116:2456-2463.
13. Sun, JC, Williams, MA and Bevan, MJ (2004). CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol 5:927-933.
14. Alexander, IE, Cunningham, SC, Logan, GJ and Christodoulou, J (2008). Potential of AAV vectors in the treatment of metabolic disease. Gene Ther 15:831-839.
15. Cao, O, Dobrzynski, E, Wang, L, Nayak, S, Mingle, B, Terhorst, C et al. (2007). Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer. Blood 110:1132-1140.
16. Cooper, M, Nayak, S, Hoffman, BE, Terhorst, C, Cao, O and Herzog, RW (2009). Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer. Hum Gene Ther 20:767-776.
17. Wang, L, Wang, H, Bell, P, McCarter, RJ, He, J, Calcedo, R et al. (2010). Systematic evaluation of AAV vectors for liver directed gene transfer in murine models. Mol Ther 18:118-125.
18. Nathwani, AC, Davidoff, AM, Hanawa, H, Hu, Y, Hoffer, FA, Nikanorov, A et al. (2002). Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques. Blood 100:1662-1669.
19. Schnell, MA, Zhang, Y, Tazelaar, J, Gao, GP, Yu, QC, Qian, R et al. (2001). Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther 3 (5 Pt 1):708-722.
20. Zhang, Y, Chirmule, N, Gao, GP, Qian, R, Croyle, M, Joshi, B et al. (2001). Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages. Mol Ther 3 (5 Pt 1):697-707.
21. Flotte, TR, Goetzmann, J, Caridi, J, Paolillo, J, Conlon, TJ, Potter, M et al. (2008). Apparently nonspecific enzyme elevations after portal vein delivery of recombinant adeno-associated virus serotype 2 vector in hepatitis C virus-infected chimpanzees. Hum Gene Ther 19:681-689.
22. Pañeda, A, Vanrell, L, Mauleon, I, Crettaz, JS, Berraondo, P, Timmermans, EJ et al. (2009). Effect of adeno-associated virus serotype and genomic structure on liver transduction and biodistribution in mice of both genders. Hum Gene Ther 20:908-917.
23. Zhu, J, Huang, X and Yang, Y (2009). The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice. J Clin Invest 119:2388-2398.