Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population

Schizophrenia Research

Volumn 118, Issue 1-3, 2010, Pages 113-117

  Aleksic, Branko ^a   Kushima, Itaru ^a   Ito, Yoshihito ^a   Nakamura, Yukako ^a   Ujike, Hiroshi ^b   Suzuki, Michio ^c,d   Inada, Toshiya ^e   Hashimoto, Ryota ^f,g   Takeda, Masatoshi ^f,g   Iwata, Nakao ^h   Ozaki, Norio ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e SEIWA HOSPITAL   (Japan)

^f Molecular Research Center for Children's Mental Development   (Japan)

^g OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

DKK1; Epistasis; Japanese population; KREMEN1; Schizophrenia; Wnt pathway

Indexed keywords

DICKKOPF 1 PROTEIN; KREMEN1 PROTEIN; MEMBRANE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; FEMALE; GENE FREQUENCY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; JAPAN; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 77951976760     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2010.01.014     Document Type: Article

References (18)

1. Benes F.M., Davidson J., Bird E.D. Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch. Gen. Psychiatry 1986, 43(1):31-35.
2. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006, 127(3):469-480.
3. Crow T.J. A Darwinian approach to the origins of psychosis. Br. J. Psychiatry 1995, 167(1):12-25.
4. Dudbridge F. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum. Hered. 2008, 66(2):87-98.
5. Emamian E.S., Hall D., Birnbaum M.J., Karayiorgou M., Gogos J.A. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat. Genet. 2004, 36(2):131-137.
6. Faraone S.V., Matise T., Svrakic D., Pepple J., Malaspina D., Suarez B., Hampe C., Zambuto C.T., Schmitt K., Meyer J., Markel P., Lee H., Harkavy Friedman J., Kaufmann C., Cloninger C.R., Tsuang M.T. Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. Am. J. Med. Genet. 1998, 81(4):290-295.
7. Haga H., Yamada R., Ohnishi Y., Nakamura Y., Tanaka T. Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism. J. Hum. Genet. 2002, 47(11):605-610.
8. Ikeda M., Takahashi N., Saito S., Aleksic B., Watanabe Y., Nunokawa A., Yamanouchi Y., Kitajima T., Kinoshita Y., Kishi T., Kawashima K., Hashimoto R., Ujike H., Inada T., Someya T., Takeda M., Ozaki N., Iwata N. Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample. Schizophr. Res. 2008, 101(1-3):1-8.
9. Li F., Chong Z.Z., Maiese K. Winding through the WNT pathway during cellular development and demise. Histol. Histopathol. 2006, 21(1):103-124.
10. Mao B., Wu W., Davidson G., Marhold J., Li M., Mechler B.M., Delius H., Hoppe D., Stannek P., Walter C., Glinka A., Niehrs C. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002, 417(6889):664-667.
11. Moore J., White B. Tuning reliefF for genome-wide genetic analysis. Lect. Notes Comput. Sci. 2007, 4447(1):166-175.
12. Moore J.H., Gilbert J.C., Tsai C.T., Chiang F.T., Holden T., Barney N., White B.C. A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. J. Theor. Biol. 2006, 241(2):252-261.
13. Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006, 25(57):7469-7481.
14. Proitsi P., Li T., Hamilton G., Di Forti M., Collier D., Killick R., Chen R., Sham P., Murray R., Powell J., Lovestone S. Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4. Biol. Psychiatry 2008, 63(1):13-16.
15. Pulver A.E., Karayiorgou M., Wolyniec P.S., Lasseter V.K., Kasch L., Nestadt G., Antonarakis S., Housman D., Kazazian H.H., Meyers D., Ott J., Lamacz M., Liang K.Y., Hanfelt J., Ullrich G., DeMarchi N., Ramu E., McHugh P.R., Adler L., Thomas M., Carpenter W.T., Manschreck T., Gordon C.T., Kimberland M., Babb R., Puck J., Childs B. Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1. Am. J. Med. Genet. 1994, 54(1):36-43.
16. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., Maller J., Sklar P., de Bakker P.I., Daly M.J., Sham P.C. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 2007, 81(3):559-575.
17. Skol A.D., Scott L.J., Abecasis G.R., Boehnke M. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat. Genet. 2006, 38(2):209-213.
18. Yamaguchi-Kabata Y., Nakazono K., Takahashi A., Saito S., Hosono N., Kubo M., Nakamura Y., Kamatani N. Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies. Am. J. Hum. Genet. 2008, 83(4):445-456.