Hypoxia-induced vasodilation and effects of regional phentolamine in awake patients with sleep apnea

Journal of Applied Physiology

Volumn 108, Issue 5, 2010, Pages 1234-1240

  Moradkhan, Raman ^a   Spitnale, Brett ^a   McQuillan, Patrick ^b   Hogeman, Cynthia ^a   Gray, Kristen S ^a   Leuenberger, Urs A ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Sleep disordered breathing; Sympathetic nervous system; Vascular function

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; PHENTOLAMINE;

ADRENERGIC SYSTEM; ADULT; ANOXIA; ARTICLE; BLOOD FLOW; BRACHIAL ARTERY; CASE CONTROL STUDY; DOPPLER FLOWMETRY; ECHOGRAPHY; FEMALE; FEMORAL ARTERY; HUMAN; INNERVATION; MALE; METHODOLOGY; MIDDLE AGED; NERVE BLOCK; PATHOPHYSIOLOGY; PERONEUS NERVE; SKELETAL MUSCLE; SKIN; SLEEP APNEA SYNDROME; VASCULARIZATION; VASOCONSTRICTION; VASODILATATION; WAKEFULNESS;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; ANOXIA; AUTONOMIC NERVE BLOCK; BRACHIAL ARTERY; CASE-CONTROL STUDIES; FEMALE; FEMORAL ARTERY; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PERONEAL NERVE; PHENTOLAMINE; REGIONAL BLOOD FLOW; SKIN; SLEEP APNEA, OBSTRUCTIVE; SYMPATHETIC NERVOUS SYSTEM; ULTRASONOGRAPHY, DOPPLER; VASOCONSTRICTION; VASODILATION; WAKEFULNESS;

EID: 77951962716     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.90855.2008     Document Type: Article

References (47)

1. Barceló A, Elorza MA, Barbé F, Santos C, Mayoralas LR, Agusti AG. Angiotensin converting enzyme in patients with sleep apnoea syndrome: plasma activity and gene polymorphisms. Eur Respir J 17: 728-732, 2001. (Pubitemid 32492564)
2. BauersachsJ,PoppR,HeckerM,SauerE,FlemingI,BusseR. Nitricoxideattenuatesthereleaseofendothelium-derivedhyperpolarizingfactor. Circulation94:3341-3347,1996.(Pubitemid26427507)
3. BlitzerML,LeeSD,CreagerMA.Endothelium- derivednitricoxidemediateshypoxicvasodilationofresistancevesselsinhumans. AmJPhysiolHeartCircPhysiol271:H1182-H1185,1996.(Pubitemid126832338)
4. Bokinsky G, Miller M, Ault K, Husband P, Mitchell J. Spontaneous platelet activation and aggregation during obstructive sleep apnea and its response to therapy with nasal continuous positive airway pressure. Chest 108: 625-630, 1995.
5. CarlsonJT,HednerJ,ElamM,EjnellH,SellgrenJ,WallinBG. Augmentedrestingsympatheticactivityinawakepatientswithobstructivesleepapnea. Chest103:1763-1768,1993.(Pubitemid23174312)
6. CarlsonJT,HednerJA,SellgrenJ,ElamM,WallinBG. Depressedbaroreflexsensitivityinpatientswithobstructivesleepapnea. AmJRespirCritCareMed154:1490-1496,1996.(Pubitemid26391203)
7. Carlson JT, Rångemark C, Hedner JA. Attenuated endothelium- dependent vascular relaxation in patients with sleep apnoea. J Hypertens 14: 577-584, 1996. (Pubitemid 26161112)
8. CarlssonI,SolleviI,WennmalmA.Theroleofmyogenicrelaxation, adenosineandprostaglandinsinhuman,forearmreactivehyperemia.JPhysiol389:147-161, 1987.(Pubitemid17115793)
9. Chin K, Ohi M, Kita H, Noguchi T, Otsuka N, Tsuboi T, Mishima M, Kuno K. Effects of NCPAP therapy on fibrinogen levels in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 153: 1972-1976, 1996.
10. 2- adrenergic vascular response in patients widi obsttuctive sleep apnea. Am J Respir Crit Care Med 162: 1480-1487, 2000.
11. Hedner JA, Wilcox I, Laks L, Grunstein RR, Sullivan CE. A specific and potent pressor effect of hypoxia in patients with sleep apnea. Am Rev Respir Dis146: 1240-1245, 1992.
12. ImadojemuVA,GleesonK,QuraishiS,KunselmanAR,SinowayLI,LeuenbergerUA. Impairedvasodilatorresponsesinobstructivesleepapneaareimprovedwithcontinuouspos itiveairwaypressuretherapy.AmJRespirCritCareMed165:950-953,2002. (Pubitemid34774663)
13. Imadojemu VA, Mawji Z, Kunselman A, Gray KS, Hogeman CS, Leuenberger UA. Sympathetic chemoreflex responses in obstructive sleep apnea and effects of continuous positive airway pressure therapy. Chest 131: 1406-1413, 2007. (Pubitemid 46762346)
14. Ip MS, Lam B, Chan LY, Zheng L, Tsang KW, Fung PC, Lam WK. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 162:2166-2171,2000.(Pubitemid32051681)
15. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 169: 348-353, 2004.
16. 2 uptake in rhythmically contracting human forearm muscles. Am J Physiol. Heart Circ Physiol. 263: H1078-H1083, 1992.
17. Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, Accurso V, Somers VK. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 102: 2607-2610, 2000.
18. KimuraH,NiijimaM,AbeY,EdoH,SakabeH,KojimaA,HasakoK,MasuyamaS,TatsumiK, KuriyamaT. Compensatoryexcretionofprostacyclinandthromboxanemetabolitesinobstructivesleepa pneasyndrome.InternMed37:127-133,1998.(Pubitemid128520828)
19. KraicziH,HednerJ,PekerY,CarlsonJ. Increasedvasoconstrictorsensitivityinobstructivesleepapnea.JApplPhysiol89: 493-498,2000.(Pubitemid30637094)
20. Krieger J, Benzoni D, Sforza E, Sassard J. Urinary excretion of prostanoids during sleep in obstructive sleep apnoea patients. Clin Exp Pharmacol Physiol 18: 551-555, 1991.
21. Lavie L. Obstructive sleep apnoea syndrome-an oxidative stress disorder. Sleep Med Rev 7: 35-51, 2003. (Pubitemid 36188305)
22. Lee F, Shoemaker JK, McQuillan PM, Kunselman AR, Smith MB, Yang QX, Smith H, Gray K, Sinoway LI. Effects of forearm Bier block with bretylium on the hemodynamic and metabolic responses to handgrip. Am J Physiol Heart Circ Physiol 279: H586-H593, 2000.
23. Lenders J, Janssen GJ, Smits P, Thien T. Role of the wrist cuff in forearm plethysmography. Clin Sci 80: 413-417, 1991.
24. Leuenberger U, Gleeson K, Wroblewski K, Prophet S, Zelis R, Zwillich C, Sinoway L. Norepinephrine clearance is increased during acute hypoxemia in humans. Am J Physiol Heart Circ Physiol 261: H1659-H1664, 1991.
25. Leuenberger U, Jacob E, Sweer L, Waravdekar N, Zwillich C, Sinoway L. Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia. J Appl Physiol 79: 581-588, 1995.
26. Leuenberger UA, Gray K, Herr MD. Adenosine contributes to hypoxiainduced forearm vasodilation in humans. J Appl Physiol 87: 2218-2224, 1999.
27. Leuenberger UA, Hogeman CS, Quraishi S, Linton-Frazier L, Gray KS. Short-term intermittent hypoxia enhances sympathetic responses to continuous hypoxia in humans. J Appl Physiol 103: 835-842, 2007. (Pubitemid 47358865)
28. Messina EJ, Sun D, Koller A, Wolin MS, Kaley G. Role of endotheliumderived prostaglandins in hypoxia-elicited arteriolar dilation in rat skeletal muscle. Circ Res 71: 790-796, 1992.
29. Monahan KD, Leuenberger UA, Ray CA. Effect of repetitive hypoxic apnoeas on baroreflex function in humans. J Physiol 574: 605-613, 2006.
30. Moradkhan R, McQuillan P, Hogeman C, Leuenberger A, Linton-Frazier L, Leuenberger UA. Metabolic forearm vasodilation is enhanced following Bier block with phentolamine. Am J Physiol Heart Circ Physiol 293: H2289-H2295, 2007. (Pubitemid 47605873)
31. Narkiewicz K,vandeBornePJ,PesekCA,DykenME,MontanoN,SomersVK. Selectivepotentiationofperipheralchemoreflexsensitivityinobstructivesleepapnea. Circulation99:1183-1189,1999.(Pubitemid29120090)
32. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD, Proctor DN. Different vasodilator responses of human arms and legs. J Physiol 556: 1001-1011, 2004.
33. NietoFJ,HerringtonDM,RedlineS,BenjaminEJ,RobbinsJA. Sleepapneaandmarkersofvascularendothelialfunctioninalargecommunitysampleofolder adults.AmJRespirCritCareMed169:354-360,2004.(Pubitemid38134814)
34. Nishikawa Y, Stepp DW, Chilian WM. Nitric oxide exerts feedback inhibition on EDHF-induced coronary arteriolar dilation in vivo. Am J Physiol Heart Circ Physiol 279: H459-H465, 2000.
35. Ohike Y, Kozaki K, Iijima K, Eto M, Kojima T, Ohga E, Santa T, Imai K, Hashimoto M, Yoshizumi M, Ouchi Y. Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure-possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine. Circ J 69: 221-226, 2005. (Pubitemid 40313045)
36. ParatiG,CasadeiR,GroppelliA,DiRienzoM,ManciaG.Comparisonoffingerandintra- arterialbloodpressuremonitoringatrestandduringlaboratorytesting.Hypertension13: 647-655,1989.(Pubitemid19157951)
37. PhillipsBG,NarkiewiczK,PesekCA,HaynesWG,DykenME,SomersVK. Effectsofobstructivesleepapneaonendothelin-1andbloodpressure.JHypertens17:61-66, 1999.(Pubitemid29086189)
38. Prabhakar NR, Peng YJ. Peripheral chemoreceptors in health and disease. J Appl Physiol 96: 359-366, 2004.
39. Ray CJ, Abbas MR, Coney AM, Marshall JM. Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. J Physiol 544: 195-209, 2002.
40. RemsburgS,LaunoisSH,WeissJW. Patientswithobstructivesleepapneahaveanabnormalperipheralvascularresponse- hypoxia.JApplPhysiol87:1148-1153,1999.(Pubitemid29436996)
41. SchulzR,HummelC,HeinemannS,SeegerW,GrimmingerF. Serumlevelsofvascularendothelialgrowthfactorareelevatedinpatientswithobstructiv esleepapneaandseverenighttimehypoxia.AmJRespirCritCareMed165:67-70,2002. (Pubitemid34053359)
42. Schulz R, Schmidt D, Blum A, Lopes-Ribeiro X, Lucke C, Mayer K, Olschewski H, Seeger W, Grimminger F. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy. Thorax 55: 1046-1051, 2000.
43. Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V, Somers VK. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 105: 2462-2464, 2002. (Pubitemid 34568964)
44. Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96: 1897-1904, 1995.
45. Venugopal SK, Devaraj S, Yuhanna I, Shaul P, Jialal I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 106: 1439-1441, 2002.
46. Villar IC, Francis S, Webb A, Hobbs AJ, Ahluwalia A. Novel aspects of endothelium-dependent regulation of vascular tone. Kidney Int 70: 840-853, 2006. (Pubitemid 44285961)
47. Weisbrod CJ, Minson CT, Joyner MJ, Halliwill JR. Effects of regional phentolamine on hypoxic vasodilatation in healthy humans. J Physiol 537: 613-621, 2001.