Alpha lipoic acid: A new treatment for neuropathic pain in patients with diabetes?

Netherlands Journal of Medicine

Volumn 68, Issue 4, 2010, Pages 158-162

  Mijnhout, G S ^a   Alkhalaf, A ^b,c   Kleefstra, N ^c,d   Bilo, H J G ^a,b,c  

^a ISALA HOSPITAL   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c Diabetes Centre   (Netherlands)

^d LANGERHANS MEDICAL RESEARCH GROUP   (Netherlands)

Author keywords

Alpha lipoic acid; Diabetes mellitus; Neuropathic pain

Indexed keywords

PLACEBO; THIOCTIC ACID;

CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIABETES MELLITUS; DIABETIC NEUROPATHY; DISEASE SEVERITY; DIZZINESS; HUMAN; NAUSEA; NEUROPATHIC PAIN; OUTCOME ASSESSMENT; QUALITY CONTROL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; REVIEW; SCORING SYSTEM; SYSTEMATIC REVIEW; TOTAL SYMPTOM SCORE; VOMITING;

DIABETIC NEUROPATHIES; HUMANS; PAIN; THIOCTIC ACID; VITAMIN B COMPLEX;

EID: 77951943315     PISSN: 03002977     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (23)

1. Ziegler D. Treatment of diabetic neuropathy and neuropathic pain: how far have we come? Diabetes Care. 2008;31(Suppl):S255-61.
2. Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577-89.
3. Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes. 2005;54:1615-25.
4. Bansal V, Kalita J, Misra UK. Diabetic neuropathy. Postgrad Med J. 2006;82:95-100.
5. Rutkove SB. A 52-year old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. JAMA. 2009;302:1451-8.
6. Reed LJ, DeBusk BG, Gunsalus IC, et al. Crystalline alpha-lipoic acid; a catalytic agent associated with pyruvate dehydrogenase. Science. 1951;114:93-4.
7. Lin J, Bierhaus A, Burgert P, et al. Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Diabetologia. 2006;49:1089-96.
8. Yi X, Maeda N. Alpha-lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/ low-cholesterol diet. Diabetes. 2006;55:2238-44.
9. Du X, Edelstein D, Brownlee M. Oral benfothiamine plus a-lipoic acid normalises complication-causing pathways in type 1 diabetes. Diabetologia. 2008;51:1930-2.
10. Singh U, Jialal I. Alpha-lipoic acid supplementation and diabetes. Nutr Rev. 2008;66:646-57.
11. Ziegler D, Schatz H, Conrad F, et al. Effects of treatment with the antioxidant a-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. Diabetes Care. 1997;20:369-73.
12. Tankova T, Koev D, Dakovska L. Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study). Rom J Intern Med. 2004;42:457-64.
13. Liu F, Zhang Y, Yang M, et al. Curative effect of a-lipoic acid on peripheral neuropathy in type 2 diabetes: A clinical study. Nat Med J China. 2007;87:2706-9.
14. Strokov IA, Kozlova NA, Mozolevskii IV, et al. The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy. Vserossiiskoe Obshchestvo Psikhiatrov. 1999;99:18-22.
15. Reljanovic M, Reichel G, Rett K, et al. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (a-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Free Rad Res. 1999;31:171-9.
16. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: a meta-analysis. Diab Med. 2004;21:114-21.
17. Mirza N, Cornblath DR, Hasan S, et al. Alpha-lipoic acid for diabetic peripheral neuropathy (Protocol). Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD005492. DOI: 10.1002/14651858.CD005492.
18. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant a-lipoic acid. Diabetologia. 1995;38:1425-33.
19. Ametov AS, Barinov A, Dyck PJ, et al. The sensory symptoms of diabetic polyneuropathy are improved with a-lipoic acid. Diabetes Care. 2003;26:770-6.
20. Ziegler D, Ametov A, Barinov A, et al. Oral treatment with a-lipoic acid improves symptomatic diabetic polyneuropathy. Diabetes Care. 2006;29:2365-70.
21. Ruhnau KJ, Meissnert HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (a-lipoic acid) in symptomatic diabetic polyneuropathy. Diab Med. 1999;16:1040-3.
22. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid. Diabetes Care. 1999;22:1296-1301.
23. Farmacotherapeutisch Kompas 2009: http://www.fk.cvz.nl/.