An EcR homolog from the filarial parasite, Dirofilaria immitis requires a ligand-activated partner for transactivation

Molecular and Biochemical Parasitology

Volumn 171, Issue 2, 2010, Pages 55-63

  Shea, Cathy ^a   Richer, Jennifer ^b   Tzertzinis, George ^a   Maina, Claude V ^a  

^a NEW ENGLAND BIOLABS   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Ecdysone; EcR; Filaria; Molting; Nuclear receptor; Rxr

Indexed keywords

CELL NUCLEUS RECEPTOR; ECDYSONE RECEPTOR; ECDYSTEROID; FARNESOL RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DIROFILARIA IMMITIS; DIROFILARIASIS; DNA BINDING; GENETIC SIMILARITY; LIGAND BINDING; MOLTING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TISSUE CULTURE; TRANSACTIVATION; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; ANIMALS; DIROFILARIA IMMITIS; DNA, HELMINTH; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; PROTEIN BINDING; RECEPTORS, STEROID; RETINOID X RECEPTORS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; TRANSCRIPTIONAL ACTIVATION;

CANIS FAMILIARIS; DIROFILARIA IMMITIS; FILARIA; HEXAPODA; NEMATODA;

EID: 77951939587     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.02.002     Document Type: Article

References (50)

1. Ottesen E.A., Ramachandran C.P. Lymphatic filariasis infection and disease: control strategies. Parasitol Today 1995, 11:129-131.
2. Michael E., Bundy D.A., Grenfell B.T. Re-assessing the global prevalence and distribution of lymphatic filariasis. Parasitology 1996, 112:409-428.
3. Filariasis, WECo. Geneva: World Health Organization; 1992.
4. Boreham P.F.L., Atwell R.B. Dirofilariasis 1988, CRC Press, Inc., Boca Raton, FL.
5. Cleator M., Delves C.J., Howells R.E., Rees H.H. Identity and tissue localization of free and conjugated ecdysteroids in adults of Dirofilaria immitis and Ascaris suum. Mol Biochem Parasitol 1987, 25:93-105.
6. Mendis A.H., Rose M.E., Rees H.H., Goodwin T.W. Ecdysteroids in adults of the nematode, Dirofilaria immitis. Mol Biochem Parasitol 1983, 9:209-226.
7. Mercer J.G., Munn A.E., Rees H.H. Caenorhabditis elegans: occurrence and metabolism of ecdysteroids in adults and dauer larvae. Comp Biochem Physiol B 1988, 90:261-267.
8. Chitwood D.J., Feldlaufer M.F. Ecdysteroids in axenically propagated Caenorhabditis elegans and culture medium. J. Nematology 1990, 22:598-607.
9. Mercer J.G., Barker G.C., Howells R.E., Rees H.H. Analysis of ecdysteroids in Onchocerca gibsoni, O. volvulus and nodule tissues. Trop Med Parasitol 1989, 40:434-439.
10. Evershed R.P., Mercer J.G., Rees H.H. Capillary gas chromatography-mass spectrometry of ecdysteroids. J Chromatogr 1987, 390:357-369.
11. Dennis R.D. Insect morphogenetic hormones and developmental mechanisms in the nematode, Nematospiroides dubius. Comp Biochem Physiol 1976, 53:53-56.
12. Fleming M.W. Ascaris suum: role of ecdysteroids in molting. Exp Parasitol 1985, 60:207-210.
13. Barker G.C., Chitwood D.J., Rees H.H. Ecdysteroids in helminths and annelids. Invertebrate Reprod Dev 1990, 18:1-11.
14. Warbrick E.V., Barker G.C., Rees H.H., Howells R.E. The effect of invertebrate hormones and potential hormone inhibitors on the third larval moult of the filarial nematode, Dirofilaria immitis, in vitro. Parasitology 1993, 107:459-463.
15. Barker G.C., Mercer J.G., Rees H.H., Howells R.E. The effect of ecdysteroids on the microfilarial production of Brugia pahangi and the control of meiotic reinitiation in the oocytes of Dirofilaria immitis. Parasitol Res 1991, 77:65-71.
16. Barker G.C., Mercer J.G., Svoboda J.A., et al. Effects of potential inhibitors on Brugia pahangi in vitro: macrofilaricidal action and inhibition of microfilarial production. Parasitology 1989, 99:409-416.
17. Andres A.J., Thummel C.S. Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone. Trends Genet 1992, 8:132-138.
18. Pongs O. Ecdysteroid-regulated gene expression in Drosophila melanogaster. Eur J Biochem 1988, 175:199-204.
19. Thummel C.S. Puffs and gene regulation--molecular insights into the Drosophila ecdysone regulatory hierarchy. Bioessays 1990, 12:561-568.
20. Ashburner M. Puffs, genes, and hormones revisited. Cell 1990, 61:1-3.
21. Riddiford L.M. The Development of Drosophila melanogaster 1993, 899-939. Cold Spring Harbor Press, Cold Spring Harbor. M. Bate, A. Martinez Arias (Eds.).
22. Yao T.P., Segraves W.A., Oro A.E., McKeown M., Evans R.M. Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. Cell 1992, 71:63-72.
23. Yao T.P., Forman B.M., Jiang Z., et al. Functional ecdysone receptor is the product of EcR and ultraspiracle genes. Nature 1993, 366:476-479.
24. Talbot W.S., Swyryd E.A., Hogness D.S. Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell 1993, 73:1323-1337.
25. Bender M., Imam F.B., Talbot W.S., Ganetzky B., Hogness D.S. Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell 1997, 91:777-788.
26. Schubiger M., Wade A.A., Carney G.E., Truman J.W., Bender M. Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis. Development 1998, 125:2053-2062. [in process citation].
27. Hodin J., Riddiford L.M. The ecdysone receptor and ultraspiracle regulate the timing and progression of ovarian morphogenesis during Drosophila metamorphosis. Dev Genes Evol 1998, 208:304-317.
28. Carney G.E., Bender M. The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis. Genetics 2000, 154:1203-1211.
29. Kastner P., Mark M., Chambon P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?. Cell 1995, 83:859-869.
30. Mangelsdorf D.J., Thummel C., Beato M., et al. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839.
31. Mangelsdorf D.J., Evans R.M. The RXR heterodimers and orphan receptors. Cell 1995, 83:841-850.
32. Thummel C.S. From embryogenesis to metamorphosis: the regulation and function of Drosophila nuclear receptor superfamily members. Cell 1995, 83:871-877.
33. Beato M., Herrlich P., Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell 1995, 83:851-857.
34. Shea C., Hough D., Xiao J., Tzertzinis G., Maina C.V. An rxr/usp homolog from the parasitic nematode, Dirofilaria immitis. Gene 2004, 324:171-182.
35. Tzertzinis G., Egana A.L., Palli S., et al. Molecular Evidence for a Functional Ecdysone Signaling System in Brugia malayi. PloS Neglected Trop Dis 2010.
36. Crossgrove K., Laudet V., Maina C.V. Dirofilaria immitis encodes Dinhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene. Mol Biochem Parasitol 2002, 119:193-201.
37. Cho W.L., Kapitskaya M.Z., Raikhel A.S. Mosquito ecdysteroid receptor: analysis of the cDNA and expression during vitellogenesis. Insect Biochem Mol Biol 1995, 25:19-27.
38. Palli S.R., Kapitskaya M.Z., Kumar M.B., Cress D.E. Improved ecdysone receptor-based inducible gene regulation system. Eur J Biochem 2003, 270:1308-1315.
39. Kapitskaya M., Wang S., Cress D.E., Dhadialla T.S., Raikhel A.S. The mosquito ultraspiracle homologue, a partner of ecdysteroid receptor heterodimer: cloning and characterization of isoforms expressed during vitellogenesis. Mol Cell Endocrinol 1996, 121:119-132.
40. Dhadialla T.S., Carlson G.R., Le D.P. New insecticides with ecdysteroidal and juvenile hormone activity. Annu Rev Entomol 1998, 43:545-569.
41. Grandea A.G., Tuyen L.K., Asikin N., et al. A lgt11 cDNA recombinant that encodes Dirofilaria immitis paramyosin. Mol Biochem Parasitol 1989, 35:31-41.
42. Kothapalli R., Palli S.R., Ladd T.R., et al. Cloning and developmental expression of the ecdysone receptor gene from the spruce budworm, Choristoneura fumiferana. Dev Genet 1995, 17:319-330.
43. Koelle M.R., Talbot W.S., Segraves W.A., et al. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 1991, 67:59-77.
44. Wurtz J.M., Bourguet W., Renaud J.P., et al. A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol 1996, 3:87-94.
45. Segraves W.A., Hogness D.S. The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily. Genes Dev 1990, 4:204-219.
46. Tanese N., Saluja D., Vassallo M.F., Chen J.L., Admon A. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. Proc Natl Acad Sci USA 1996, 93:13611-13616.
47. Saluja D., Vassallo M.F., Tanese N. Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators. Mol Cell Biol 1998, 18:5734-5743.
48. Watt K., Jess T.J., Kelly S.M., Price N.C., McEwan I.J. Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions. Biochemistry 2005, 44:734-743.
49. Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V. The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes. Genome Res 1999, 9:103-120.
50. Abad P., Gouzy J., Aury J.M., et al. Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita. Nat Biotechnol 2008, 26:909-915.