Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development

Human Pathology

Volumn 41, Issue 6, 2010, Pages 838-847

  Fujita, Nobuhiro ^a   Aishima, Shinichi ^a   Iguchi, Tomohiro ^a   Nishihara, Yunosuke ^a   Yamamoto, Hidetaka ^a   Taketomi, Akinobu ^a   Oda, Yoshinao ^a   Honda, Hiroshi ^a   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Arterial vessel density; Calponin; CD34; h caldesmon; Hepatocellular carcinoma

Indexed keywords

CALDESMON; CALPONIN; CD34 ANTIGEN; KI 67 ANTIGEN;

ADULT; AGED; ARTICLE; CANCER INFILTRATION; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HEPATIC ARTERY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROGNOSIS; TUMOR VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD34; ARTERIES; CALCIUM-BINDING PROTEINS; CALMODULIN-BINDING PROTEINS; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; KI-67 ANTIGEN; LIVER NEOPLASMS; MALE; MICROFILAMENT PROTEINS; MICROVESSELS; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; SURVIVAL RATE;

EID: 77951938430     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.11.011     Document Type: Article

References (32)

1. Okuda K. Hepatocellular carcinoma: clinicopathological aspects. J Gastroenterol Hepatol 12 (1997) 314-318
2. Bosch F.X., Ribes J., Díaz M., and Cléries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology 127 (2004) 5-16
3. Feitelson M.A., Sun B., Satiroglu Tufan N.L., et al. Genetic mechanisms of hepatocarcinogenesis. Oncogene 21 (2002) 2593-2604
4. Kudo M. Multistep human hepatocarcinogenesis: correlation of imaging with pathology. J Gastroenterol 44 Suppl 19 (2009) 112-118
5. Ueda K., Terada T., Nakanuma Y., and Matsui O. Vascular supply in adenomatous hyperplasia of the liver and hepatocellular carcinoma: a morphometric study. Hum Pathol 23 (1992) 619-626
6. Tajima T., Honda H., Taguchi K., et al. Sequential hemodynamic change in hepatocellular carcinoma and dysplastic nodules: CT angiography and pathologic correlation. AJR Am J Roentgenol 178 (2002) 885-897
7. Hayashi M., Matsui O., Ueda K., et al. Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intraarterial injection of contrast medium. AJR Am J Roentgenol 172 (1999) 969-976
8. Asayama Y., Yoshimitsu K., Irie H., et al. Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries. J Comput Assist Tomogr 31 (2007) 188-192
9. Asayama Y., Yoshimitsu K., Nishihara Y., et al. Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation. AJR Am J Roentgenol 190 (2008) 28-34
10. Tanigawa N., Lu C., Mitsui T., and Miura S. Quantitation of sinusoid-like vessels in hepatocellular carcinoma: its clinical and prognostic significance. Hepatology 26 (1997) 1216-1223
11. El-Assal O.N., Yamanoi A., Soda Y., et al. Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology 27 (1998) 1554-1562
12. Sun H.C., Tang Z.Y., Li X.M., et al. Microvessel density of hepatocellular carcinoma: its relationship with prognosis. J Cancer Res Clin Oncol 125 (1999) 419-426
13. Nanashima A., Nakayama T., Sumida Y., et al. Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma. World J Gastroenterol 14 (2008) 4915-4922
14. Morinaga S., Imada T., Shimizu A., et al. Angiogenesis in hepatocellular carcinoma as evaluated by alpha smooth muscle actin immunohistochemistry. Hepatogastroenterology 48 (2001) 224-228
15. Sasaki Y., Yamamura H., Kawakami Y., et al. Expression of smooth muscle calponin in tumor vessels of human hepatocellular carcinoma and its possible association with prognosis. Cancer 94 (2002) 1777-1786
16. Lauwers G.Y., Terris B., Balis U.J., et al. International Cooperative Study Group on Hepatocellular Carcinoma. Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index. Am J Surg Pathol 26 (2002) 25-34
17. Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. The Liver Cancer Study Group of Japan. Cancer 74 (1994) 2772-2780
18. Owens G.K. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75 (1995) 487-517
19. Frid M.G., Shekhonin B.V., Koteliansky V.E., and Glukhova M.A. Phenotypic changes of human smooth muscle cells during development: late expression of heavy caldesmon and calponin. Dev Biol 153 (1992) 185-193
20. Miettinen M.M., Sarlomo-Rikala M., Kovatich A.J., and Lasota J. Calponin and h-caldesmon in soft tissue tumors: consistent h-caldesmon immunoreactivity in gastrointestinal stromal tumors indicates traits of smooth muscle differentiation. Mod Pathol 12 (1999) 756-762
21. Hirohashi S., Ishak K.G., Kojiro M., et al. Hepatocellular carcinoma. In: Hamilton S.R., and Aaltonen L.A. (Eds). World Health Organization classification of tumors: pathology and genetics of tumors of the digestive system (2000), IARC press, Lyon, France 159-172
22. Weidner N., Semple J.P., Welch W.R., and Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324 (1991) 1-8
23. Yancopoulos G.D., Davis S., Gale N.W., et al. Vascular-specific growth factors and blood vessel formation. Nature 407 (2000) 242-248
24. Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol 237 (1999) 1-30
25. Suri C., Jones P.F., Patan S., et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87 (1996) 1171-1180
26. Maisonpierre P.C., Suri C., Jones P.F., et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277 (1997) 55-60
27. Holash J., Wiegand S.J., and Yancopoulos G.D. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18 (1999) 5356-5362
28. Wada H., Nagano H., Yamamoto H., et al. Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha. Liver Int 26 (2006) 414-423
29. Sugimachi K., Tanaka S., Taguchi K., et al. Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma. J Clin Pathol 56 (2003) 854-860
30. Torimura T., Ueno T., Kin M., et al. Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma. J Hepatol 40 (2004) 799-807
31. Mitsuhashi N., Shimizu H., Ohtsuka M., et al. Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology 37 (2003) 1105-1113
32. Yamaguchi R., Yano H., Iemura A., et al. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 28 (1998) 68-77