Effects of Hypoxia Due to Isovolemic Hemodilution on an Ex Vivo Normothermic Perfused Liver Model

Journal of Surgical Research

Volumn 160, Issue 1, 2010, Pages 73-80

  Gravante, Gianpiero ^a   Ong, Seok Ling ^a   Metcalfe, Matthew S ^a   Sorge, Roberto ^b   Bikhchandani, Jay ^a   Lloyd, David M ^a   Dennison, Ashley R ^a  

^a UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

ex vivo model; hemodilution; hypoxia; liver physiology

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; BLOOD LEVEL; BODY TEMPERATURE; CONTROLLED STUDY; FEMALE; HEMODILUTION; HEPATIC ARTERY; HYPERGLYCEMIA; HYPOXIA; LIVER PERFUSION; NONHUMAN; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; REGULATORY MECHANISM; TISSUE OXYGENATION; VEIN BLOOD FLOW;

ANIMALS; ANOXIA; DISEASE MODELS, ANIMAL; FEMALE; HEMODILUTION; LIVER; PERFUSION; SWINE;

EID: 77951928778     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.09.024     Document Type: Article

References (23)

1. Chen X.Q., Dong J., Niu C.Y., et al. Effects of hypoxia on glucose, insulin, glucagon, and modulation by corticotropin-releasing factor receptor type 1 in the rat. Endocrinology 148 (2007) 3271
2. Klaus S., Heringlake M., Gliemroth J., et al. Biochemical tissue monitoring during hypoxia and reoxygenation. Resuscitation 56 (2003) 299
3. Stratford L.L., and Hooper S.B. Effect of hypoxemia on tissue glycogen content and glycolytic enzyme activities in fetal sheep. Am J Physiol 272 1 Pt 2 (1997) R103
4. Larsen J.J., Hansen J.M., Olsen N.V., et al. The effect of altitude hypoxia on glucose homeostasis in men. J Physiol 504 Pt 1 (1997) 241
5. Bernard C. Sur le mechanisme de la formation du sucre dans la foie. Cr Acad Sci (Par) 41 (1855) 461
6. Abouna G.M., Ashcroft T., Hull C., Hodson A., et al. The assessment of function of the isolated perfused porcine liver. Br J Surg 56 (1969) 289
7. Powell G.M., Hugher H.M., and Curtis C.G. Isolated perfused liver technology for studying metabolic and toxicological problems. Drug Metab Drug Interact 7 (1989) 53
8. Vuppugalla R., and Mehvar R. Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers. Drug Metab Dispos 34 (2007) 1160
9. Strubelt O., Kremer J., Tilse A., et al. Comparative studies on the toxicity of mercury, cadmium, and copper toward the isolated perfused rat liver. J Toxicol Environ Health 47 (1996) 267
10. Hung D.Y., Siebert G.A., Chang P., et al. Disposition kinetics of propranolol isomers in the perfused rat liver. J Pharmacol Exp Ther 311 (2004) 822
11. Wilhelm M., Jaeger D.E., Schull-Cablitz H., et al. Hepatic clearance and retention of aluminium. Toxicol Lett 89 (1996) 257
12. Imber C.J., St Peter S.D., De Cenarruzabeitia I.L., et al. Advantages of normothermic perfusion over cold storage in liver preservation. Transplantation 73 (2002) 701
13. Imber C.J., St. Peter S.D., De Cenarruzabeitia I.L., et al. Optimization of bile production during normothermic preservation of porcine livers. Am J Transplant 2 (2002) 593
14. Butler A.J., Rees M.A., Wight D.G., et al. Successful extracorporeal porcine liver perfusion for 72 hours. Transplantation 73 (2002) 1212
15. Adham M., Peyrol S., Chevallier M., et al. The isolated perfused porcine liver: Assessment of viability during and after six hours of perfusion. Transpl Int 10 (1997) 299
16. Aggarwal S., Obrist W., Yonas H., et al. Cerebral hemodynamic and metabolic profiles in fulminant hepatic failure: relationship to outcome. Liver Transpl 11 (2005) 1353
17. Simonenkov A.P. Reasoning in favor of changes in classification of the hypoxic conditions. Biull Eksp Biol Med 127 (1999) 146
18. Mathew J.P., Mackensen G.B., Phillips-Bute B., et al. Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly. Anesthesiology 107 (2007) 577
19. Weiland A.P., and Walker W.E. Physiologic principles and clinical sequelae of cardiopulmonary bypass. Heart Lung 15 (1986) 34
20. Nowak G., Ungerstedt J., Wernerman J., et al. Metabolic changes in the liver graft monitored continuously with microdialysis during liver transplantation in a pig model. Liver Transpl 8 (2002) 424
21. Kannerup A.S., Funch-Jensen P., Grønbaek H., et al. Metabolic changes in the pig liver during warm ischemia and reperfusion measured by microdialysis. J Gastrointest Surg 12 (2008) 319
22. Fukusaki M., Maekawa T., Yamaguchi K., et al. Combined effects of prolonged prostaglandin E1-induced hypotension and haemodilution on human hepatic function. Eur J Anaesthesiol 14 (1997) 157
23. Adham M., Peyrol S., Chevallier M., et al. The isolated perfused porcine liver: Assessment of viability during and after 6 hours of perfusion. Transpl Int 10 (1997) 299