Activation of Leishmania (Leishmania) amazonensis arginase at low temperature by binuclear Mn2+ center formation of the immobilized enzyme on a Ni2+ resin

Experimental Parasitology

Volumn 125, Issue 2, 2010, Pages 152-155

  Silva, Edson R ^a   Floeter Winter, Lucile M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Arginase (EC 3.5.3.1); Chemotherapy; Leishmania; Metalloenzyme

Indexed keywords

ARGINASE 1; MANGANESE; NICKEL; RESIN; ARGINASE; IMMOBILIZED ENZYME; ION EXCHANGE RESIN; MANGANESE DERIVATIVE; MANGANESE SULFATE; RECOMBINANT PROTEIN; SULFATE;

ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME BINDING; ENZYME IMMOBILIZATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SYNTHESIS; HEATING; LEISHMANIA; LOW TEMPERATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LEISHMANIA MEXICANA; METABOLISM;

LEISHMANIA AMAZONENSIS;

ARGINASE; ENZYME ACTIVATION; ENZYMES, IMMOBILIZED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ION EXCHANGE RESINS; LEISHMANIA MEXICANA; MANGANESE COMPOUNDS; NICKEL; RECOMBINANT PROTEINS; SULFATES;

EID: 77951920201     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.01.013     Document Type: Article

References (18)

1. ω-hydroxy-nor-l-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. Journal of Hypertension 2008, 26:1110-1118.
2. Bewley M.C., Lott J.S., Baker E.N., Patchett M.L. The cloning, expression and crystallisation of a thermostable arginase. FEBS Letters 1996, 386:215-218.
3. Bond J.S., Failla M.L., Unger D.F. Elevated manganese concentration and arginase activity in livers of streptozotocin-induced diabetic rats. The Journal of Biological Chemistry 1983, 258:8004-8009.
4. Chang C.I., Liao J.C., Kuo L. Arginase modulates nitric oxide production in activated macrophages. American Journal of Physiology-Heart and Circulatory Physiology 1998, 274:H342-H348.
5. Colleluori D.M., Morris S.M., Ash D.E. Expression, purification, and characterization of human type II arginase. Archives of Biochemistry and Biophysics 2001, 389:135-143.
6. Cox J.D., Kim N.N., Traish A.M., Christianson D.W. Arginase-boronic acid complex highlights a physiological role in erectile function. Nature Structural Biology 1999, 6:1043-1047.
7. da Silva E.R., da Silva M.F., Fischer H., et al. Biochemical and biophysical properties of a highly active recombinant arginase from Leishmania (Leishmania) amazonensis and subcellular localization of native enzyme. Molecular & Biochemical Parasitology 2008, 159:104-111.
8. Forstermann U., Kleinert H., Gath I., Schwarz P., Closs E.I., Dun N.J. Expression and expressional control of nitric oxide synthases in various cell types. Advances in Pharmacology 1995, 34:171-186.
9. Gobert A.P., McGee D.J., Akhtar M., et al. Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survival. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:13844-13849.
10. Hirsch-Kolb H., Kolb H.J., Greenberg D.M. Nuclear magnetic resonance studies of manganese binding of rat liver arginase. The Journal of Biological Chemistry 1971, 246:395-401.
11. Iniesta V., Gomez-Nieto L.C., Corraliza I. The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages. The Journal of Experimental Medicine 2001, 193:777-784.
12. Krebs H.A. Urea formation in mammalian liver. Biochemical Journal 1942, 36:758-767.
13. Lavulo L.T., Sossong T.M., Brigham-Burke M.R., et al. Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid. The Journal of Biological Chemistry 2001, 276:14242-14248.
14. Parat M.O., Richard M.J., Leccia M.T., et al. Does manganese protect cultured human skin fibroblasts against oxidative injury by uva, dithranol and hydrogen peroxide?. Free Radical Research 1995, 23:339-351.
15. Reczkowski R.S., Ash D.E. EPR evidence for binuclear manganese(II) centers in rat liver arginase. Journal of the American Chemical Society 1992, 114:10992-10994.
16. Roberts S.C., Tancer M.J., Polinsky M.R., et al. Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants. The Journal of Biological Chemistry 2004, 279:23668-23678.
17. Scolnick L.R., Kanyo Z.F., Cavalli R.C., et al. Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function. Biochemistry 1997, 36:10558-10565.
18. Wu G., Morris S.M. Arginine metabolism: nitric oxide and beyond. Biochemical Journal 1998, 336:1-17.