Incidental findings of brain magnetic resonance imaging study in a pediatric cohort in Japan and recommendation for a model management protocol

Journal of Epidemiology

Volumn 20, Issue SUPPL.2, 2010, Pages

  Seki, Ayumi ^a,b,c   Uchiyama, Hitoshi ^a,b,c   Fukushi, Tamami ^a   Sakura, Osamu ^a,d   Tatsuya, Koeda ^a,b,c  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Brain imaging; Incidental findings; MRI; Neuroethics; Research ethics

Indexed keywords

ARTICLE; BRAIN; CHILD; CLASSIFICATION; CLINICAL PROTOCOL; COHORT ANALYSIS; FEMALE; HUMAN; INCIDENTAL FINDING; JAPAN; LABORATORY DIAGNOSIS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATIENT REFERRAL; PRESCHOOL CHILD; STANDARD; STATISTICS; THREE DIMENSIONAL IMAGING;

BRAIN; CHILD; CHILD, PRESCHOOL; CLINICAL PROTOCOLS; COHORT STUDIES; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; INCIDENTAL FINDINGS; JAPAN; MAGNETIC RESONANCE IMAGING; MALE; REFERRAL AND CONSULTATION;

EID: 77951918314     PISSN: 09175040     EISSN: 13499092     Source Type: Journal    
DOI: 10.2188/jea.JE20090196     Document Type: Article

References (14)

1. Illes J, Kirschen MP, Karetsky K, Kelly M, Saha A, Desmond JE, et al. Discovery and disclosure of incidental findings in neuroimaging research. J Magn Reson Imaging. 2004;20:743-7.
2. National Institute of Neurological Disorders and Stroke [homepage on internet]. Detection and Disclosure of Incidental Findings in Neuroimaging Research. NINDS workshop and conference proceedings. [cited 2009 Nov. 11]. Available from: http://www.ninds.nih.gov/news_and_events/proceedings/ifexecsummary.htm.
3. Japan Neuroscience Society [homepage on the internet]. Guidelines for ethics-related problems with " non-invasive research on human brain function" (Revised: 3 February 2009) [cited 2009, Nov. 11]. Available from: http://www.jnss.org/english/society/rinri.html.
4. Wolf SM, Lawrenz FP, Nelson CA, Kahn JP, Cho MK, Clayton EW, et al. Managing incidental findings in human subjects research: analysis and recommendations. J Law Med Ethics. 2008;36:219-48.
5. Illes J, Kirschen MP, Edwards E, Bandettini P, Cho MK, Ford PJ, et al. Practical approaches to incidental findings in brain imaging research. Neurology. 2008;70:384-90.
6. Kirschen MP, Jaworska A, Illes J. Subjects' expectations in neuroimaging research. J Magn Reson Imaging. 2006;23:205-9.
7. Illes J, Rosen AC, Huang L, Goldstein RA, Raffin TA, Swan G, et al. Ethical consideration of incidental findings on adult brain MRI in research. Neurology. 2004;62:888-90.
8. Vernooij MW, Ikram MA, Tanghe HL, Vincent AJ, Hofman A, Krestin GP, et al. Incidental findings on brain MRI in the general population. N Engl J Med. 2007;357:1821-8.
9. Katzman GL, Dagher AP, Patronas NJ. Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers. JAMA. 1999;282:36-9.
10. Kim BS, Illes J, Kaplan RT, Reiss A, Atlas SW. Incidental findings on pediatric MR images of the brain. AJNR Am J Neuroradiol. 2002;23:1674-7.
11. Weber F, Knopf H. Incidental findings in magnetic resonance imaging of the brains of healthy young men. J Neurol Sci. 2006;240:81-4.
12. Gupta SN, Belay B. Intracranial incidental findings on brain MR images in a pediatric neurology practice: a retrospective study. J Neurol Sci. 2008;264:34-7.
13. JST/RISTEX (Japan Science and Technology Agency, Research on Science and Technology for Society) [homepage on internet]. R&D Project: Identification of Factors Affecting Cognitive and Behavioral Development of Children in Japan Based on a Cohort Study; Japan Children's Study (FY2004-2008) [cited 2009 Nov. 11]. Available from: http://www.ristex.jp/EN/examin/brain/index.html.
14. Fukushi T, Sakura O, Koizumi H. Ethical considerations of neuroscience research: the perspectives on neuroethics in Japan. Neurosci Res. 2007;57:10-6.