-
1
-
-
0034644525
-
TOR, a central controller of cell growth
-
10.1016/S0092-8674(00)00117-3, 11057898
-
Schmelzle T, Hall M. TOR, a central controller of cell growth. Cell 2000, 103:253-262. 10.1016/S0092-8674(00)00117-3, 11057898.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.2
-
2
-
-
0030915898
-
Rapamycin suppresses 5' TOP mRNA translation through inhibition of p70s6k
-
1169993, 9218810, 10.1093/emboj/16.12.3693
-
Jefferies H, Fumagalli S, Dennis PB. Rapamycin suppresses 5' TOP mRNA translation through inhibition of p70s6k. EMBO J 1997, 16:3693-3704. 1169993, 9218810, 10.1093/emboj/16.12.3693.
-
(1997)
EMBO J
, vol.16
, pp. 3693-3704
-
-
Jefferies, H.1
Fumagalli, S.2
Dennis, P.B.3
-
3
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
-
316780, 10364159, 10.1101/gad.13.11.1422
-
Gingras A, Gygi S, Raught B. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev 1999, 13:1422-1437. 316780, 10364159, 10.1101/gad.13.11.1422.
-
(1999)
Genes Dev
, vol.13
, pp. 1422-1437
-
-
Gingras, A.1
Gygi, S.2
Raught, B.3
-
4
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
10.1038/nrc839, 12094235
-
Vivanco I, Sawyers C. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2:489-501. 10.1038/nrc839, 12094235.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.2
-
5
-
-
34250184724
-
Combination of the mammalian target of rapamycin (mTOR) inhibitor everolimus (E) with the insulin like growth factor-1-receptor (IGF-1-R) inhibitor NVP-AEW-541: a mechanistic based anti-tumor strategy
-
Di Cosimo S, Seoane J, Guzman M. Combination of the mammalian target of rapamycin (mTOR) inhibitor everolimus (E) with the insulin like growth factor-1-receptor (IGF-1-R) inhibitor NVP-AEW-541: a mechanistic based anti-tumor strategy. J Clin Oncol 2005, 23(Suppl 16):3112.
-
(2005)
J Clin Oncol
, vol.23
, Issue.SUPPL.16
, pp. 3112
-
-
Di Cosimo, S.1
Seoane, J.2
Guzman, M.3
-
6
-
-
51349091290
-
The PI3-K/AKT/mTOR pathway as a target for breast cancer therapy
-
Di Cosimo S, Scaltriti M, Val D. The PI3-K/AKT/mTOR pathway as a target for breast cancer therapy. J Clin Oncol 2007, 25(Suppl 18):3511.
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL.18
, pp. 3511
-
-
Di Cosimo, S.1
Scaltriti, M.2
Val, D.3
-
7
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
2518073, 18725988
-
Carracedo A, Ma L, Teruya-Feldstein J. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008, 118:3065-3074. 2518073, 18725988.
-
(2008)
J Clin Invest
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
-
8
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
10.1016/j.molcel.2006.03.029, 16603397
-
Sarbassov DD, Ali SM, Sengupta S. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006, 22:159-168. 10.1016/j.molcel.2006.03.029, 16603397.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
-
9
-
-
51049118140
-
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
-
2680495, 18676830, 10.1158/0008-5472.CAN-07-6854
-
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008, 68:6084-6091. 2680495, 18676830, 10.1158/0008-5472.CAN-07-6854.
-
(2008)
Cancer Res
, vol.68
, pp. 6084-6091
-
-
Stemke-Hale, K.1
Gonzalez-Angulo, A.M.2
Lluch, A.3
-
10
-
-
77951945506
-
Status of PI3K inhibition and biomarker development in cancer therapeutics
-
Markman B, Atzori F, Pérez-García J. Status of PI3K inhibition and biomarker development in cancer therapeutics. Ann Oncol 2009,
-
(2009)
Ann Oncol
-
-
Markman, B.1
Atzori, F.2
Pérez-García, J.3
-
11
-
-
43249131245
-
Dose - and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors
-
10.1200/JCO.2007.14.5482, 18332469
-
Tabernero J, Rojo F, Calvo E. Dose - and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 2008, 26:1603-1610. 10.1200/JCO.2007.14.5482, 18332469.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1603-1610
-
-
Tabernero, J.1
Rojo, F.2
Calvo, E.3
-
12
-
-
73649109111
-
Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163
-
10.1200/JCO.2008.21.3033, 19687332
-
Ellard SL, Clemons M, Gelmon KA. Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163. J Clin Oncol 2009, 27:4536-4549. 10.1200/JCO.2008.21.3033, 19687332.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4536-4549
-
-
Ellard, S.L.1
Clemons, M.2
Gelmon, K.A.3
-
13
-
-
66849136781
-
Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
-
10.1200/JCO.2008.18.8391, 19380449
-
Baselga J, Semiglazov V, van Dam P. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 2009, 27:2630-2637. 10.1200/JCO.2008.18.8391, 19380449.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2630-2637
-
-
Baselga, J.1
Semiglazov, V.2
van Dam, P.3
-
14
-
-
8344231370
-
Phase II, 3 arm study of CCI-779 in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancer. Preliminary results
-
Baselga J, Fumoleau P, Gil M. Phase II, 3 arm study of CCI-779 in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancer. Preliminary results. J Clin Oncol 2004, 22(Suppl 14):544.
-
(2004)
J Clin Oncol
, vol.22
, Issue.SUPPL.14
, pp. 544
-
-
Baselga, J.1
Fumoleau, P.2
Gil, M.3
-
15
-
-
34447106387
-
Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer
-
Chow LWS, Sun Y, Jassem J. Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer. Breast Cancer Res Treat 2006, 100(Suppl 1):6091.
-
(2006)
Breast Cancer Res Treat
, vol.100
, Issue.SUPPL.1
, pp. 6091
-
-
Chow, L.W.S.1
Sun, Y.2
Jassem, J.3
-
16
-
-
61749100826
-
Multicenter phase I clinical trial of daily and weekly RAD001 in combination with weekly paclitaxel and trastuzumab in patients with HER2-overex-pressing metastatic breast cancer with prior resistance to trastuzumab
-
André F, Campone M, Hurvitz SA. Multicenter phase I clinical trial of daily and weekly RAD001 in combination with weekly paclitaxel and trastuzumab in patients with HER2-overex-pressing metastatic breast cancer with prior resistance to trastuzumab. J Clin Oncol 2008, 26(Suppl 20):1003.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.20
, pp. 1003
-
-
André, F.1
Campone, M.2
Hurvitz, S.A.3
|