Antisickling and toxicological profiles of leaf and stem of Parquetina nigrescens L

Journal of Medicinal Plants Research

Volumn 4, Issue 8, 2010, Pages 639-643

  Imaga, N O A ^a   Gbenle, G O ^a   Okochi, V I ^a   Adenekan, S O ^a   Edeoghon, S O ^a   Kehinde, M O ^a   Bamiro, S B ^a   Ajiboye, A ^a   Obinna, A ^a  

^a UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

Antisickling activity; Membrane integrity; Osmotic fragility; Parquetina nigrescens; Sickle cell disease

Indexed keywords

ANTISICKLING AGENT; HEMOGLOBIN; METHANOL; PARQUETINA NIGRESCENS EXTRACT; PLANT EXTRACT; SALICYLIC ACID; SODIUM METABISULFITE; UNCLASSIFIED DRUG; WATER;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; ASCLEPIADACEAE; CELL SUSPENSION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ERYTHROCYTE FRAGILITY; ERYTHROCYTE MEMBRANE; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HISTOPATHOLOGY; HUMAN; LETHAL DOSE; MALE; NONHUMAN; PARQUETINA NIGRESCENS; PLANT LEAF; PLANT STEM; RAT; SICKLE CELL ANEMIA; TOXICITY TESTING;

APOCYNACEAE; PARQUETINA NIGRESCENS;

EID: 77951913762     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Acquaye CTA, Young JD, Ellory JC, Gorecki M, Wilcher M (1982). Mode of transport and possible mechanism of action of L-Phenylalamine benzylester as an antisickling agent. Biochimica Biophysica Acta. 693: 407-416.
2. Bunn FH (1997). Pathogenesis and Treatment of Sickle Cell Disease. The New Eng. J. Med. 337: 762-769.
3. Ekeke GI, Shode FO (1985). The Reversion of Sickled cells by Cajanus cajan. Planta med. 6: 504-507.
4. Horwitz W (2000). Official Methods of Analysis of AOAC International, 17th Edition. USA. pp. 30-59.
5. Iyamu EW, Turner EA, Asakura T (2003). Niprisan (Nix - 0699) improves the survival rates of transgenic sickle cell mice under acute severe hypoxic conditions. Brit. J. Hematol. 122: 1001-1008.
6. Jaja SI, Kehinde MO, Gbenebitse S, Mojiminyi FBO, Ogungbemi AI (2000). Effect of vitamin C on arterial blood pressure, irreversible sickled cells and osmotic fragility in sickle cell anemia subjects. Niger. J. Physiol. Sci. 16(1-2): 14-18.
7. Kade IJ, Kotila OO, Ayeleso AO, Olaleye AA, Olawoye TL (2003). Antisickling properties of Parquetina nigrescens. Biomed. Res. (Alligarh). 14: 185-188.
8. Ogoda OJ, Akubue PI, Okide GB (2002). The Kinetics of Reversal of Pre-sickled Erythrocytes by the Aqueous Extract of Cajanus Cajan seeds. Phytother. Res. 16: 1-3.
9. Sofowora EA, Issacs-Sodeye NA, Ogunkoya LO (1975). Antisickling properties of Fagara. Lloydia 38: 169-171.