Development of a screen to dissect Toxoplasma gondii egress

Molecular and Biochemical Parasitology

Volumn 171, Issue 2, 2010, Pages 97-103

  Eidell, Keith P ^a   Burke, Thomas ^a,b   Gubbels, Marc Jan ^a  

^a BOSTON COLLEGE   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Calcium; Dithiotreitol; Egress; Genetic screen; Ionophore; Toxoplasma gondii

Indexed keywords

DITHIOTHREITOL; GLYCAN; MUTANT PROTEIN;

ARTICLE; CELL SEPARATION; CONTROLLED STUDY; EXTRACELLULAR SPACE; GENETIC SCREENING; IN VITRO STUDY; INTRACELLULAR MEMBRANE; LETHALITY; NONHUMAN; PARASITE VIRULENCE; PHENOTYPE; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SCREENING TEST; SEPARATION TECHNIQUE; SPECIES INVASION; STRAIN IDENTIFICATION; TEMPERATURE SENSITIVITY;

CELLS, CULTURED; FIBROBLASTS; GENETICS, MICROBIAL; HUMANS; MUTAGENESIS; PARASITOLOGY; TOXOPLASMA;

TOXOPLASMA GONDII;

EID: 77951908253     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.03.004     Document Type: Article

References (39)

1. Black M.W., Boothroyd J.C. Lytic cycle of Toxoplasma gondii. Microbiol Mol Biol Rev 2000, 64:607-623.
2. Hoff E.F., Carruthers V.B. Is Toxoplasma egress the first step in invasion?. Trends Parasitol 2002, 18:251-255.
3. Lavine M.D., Arrizabalaga G. Invasion and egress by the obligate intracellular parasite Toxoplasma gondii: potential targets for the development of new antiparasitic drugs. Curr Pharm Des 2007, 13:641-651.
4. Carruthers V.B., Tomley F.M. Microneme proteins in apicomplexans. Subcell Biochem 2008, 47:33-45.
5. Meissner M., Schluter D., Soldati D. Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science 2002, 298:837-840.
6. Endo T., Yagita K. Effect of extracellular ions on motility and cell entry in Toxoplasma gondii. J Protozool 1990, 37:133-138.
7. Moudy R., Manning T.J., Beckers C.J. The loss of cytoplasmic potassium upon host cell breakdown triggers egress of Toxoplasma gondii. J Biol Chem 2001, 276:41492-41501.
8. Nagamune K., Hicks L.M., Fux B., Brossier F., Chini E.N., Sibley L.D. Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature 2008, 451:207-210.
9. 2+ flux causes egress of parasites from the parasitophorous vacuole. Exp Parasitol 1997, 87:88-97.
10. Melzer T., Duffy A., Weiss L.M., Halonen S.K. The gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytes. Infect Immun 2008, 76:4883-4894.
11. Endo T., Sethi K.K., Piekarski G. Toxoplasma gondii: calcium ionophore A23187-mediated exit of trophozoites from infected murine macrophages. Exp Parasitol 1982, 53:179-188.
12. Nagamune K., Moreno S.N., Chini E.N., Sibley L.D. Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem 2008, 47:70-81.
13. 2+] and stimulate microneme discharge in Toxoplasma gondii. Biochem J 1999, 342(Pt. 2):379-386.
14. Chini E.N., Nagamune K., Wetzel D.M., Sibley L.D. Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii. Biochem J 2005, 389:269-277.
15. Arrizabalaga G., Ruiz F., Moreno S., Boothroyd J.C. Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation. J Cell Biol 2004, 165:653-662.
16. Nagamune K., Moreno S.N., Sibley L.D. Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis. Antimicrob Agents Chemother 2007, 51:3816-3823.
17. 2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence. Mol Microbiol 2005, 55:1034-1045.
18. Kieschnick H., Wakefield T., Narducci C.A., Beckers C. Toxoplasma gondii attachment to host cells is regulated by a calmodulin-like domain protein kinase. J Biol Chem 2001, 276:12369-12377.
19. Nagamune K., Sibley L.D. Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa. Mol Biol Evol 2006, 23:1613-1627.
20. Green J.L., Rees-Channer R.R., Howell S.A., et al. The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase. J Biol Chem 2008.
21. Liu L., Tucker S.C., Satir B.H. Toxoplasma PRP1 is an ortholog of parafusin (PFUS) in vesicle scaffold assembly in Ca(2+)-regulated exocytosis. Eur J Cell Biol 2009.
22. Kafsack B.F., Pena J.D., Coppens I., Ravindran S., Boothroyd J.C., Carruthers V.B. Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells. Science 2009, 323:530-533.
23. Gubbels M.J., Lehmann M., Muthalagi M., et al. Forward genetic analysis of the apicomplexan cell division cycle in Toxoplasma gondii. PLoS Pathog 2008, 4:e36.
24. Roos D.S., Donald R.G., Morrissette N.S., Moulton A.L. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol 1994, 45:27-63.
25. Gubbels M.J., Li C., Striepen B. High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein. Antimicrob Agents Chemother 2003, 47:309-316.
26. Chtanova T., Schaeffer M., Han S.J., et al. Dynamics of neutrophil migration in lymph nodes during infection. Immunity 2008, 29:487-496.
27. Couvreur G., Sadak A., Fortier B., Dubremetz J.F. Surface antigens of Toxoplasma gondii. Parasitology 1988, 97(Pt. 1):1-10.
28. Camps M., Boothroyd J.C. Toxoplasma gondii: selective killing of extracellular parasites by oxidation using pyrrolidine dithiocarbamate. Exp Parasitol 2001, 98:206-214.
29. Chandramohanadas R., Davis P.H., Beiting D.P., et al. Apicomplexan parasites Co-Opt host calpains to facilitate their escape from infected cells. Science 2009.
30. Black M.W., Arrizabalaga G., Boothroyd J.C. Ionophore-resistant mutants of Toxoplasma gondii reveal host cell permeabilization as an early event in egress. Mol Cell Biol 2000, 20:9399-9408.
31. Uyetake L., Ortega-Barria E., Boothroyd J.C. Isolation and characterization of a cold-sensitive attachment/invasion mutant of Toxoplasma gondii. Exp Parasitol 2001, 97:55-59.
32. Carruthers V.B., Hakansson S., Giddings O.K., Sibley L.D. Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment. Infect Immun 2000, 68:4005-4011.
33. Ortega-Barria E., Boothroyd J.C. A Toxoplasma lectin-like activity specific for sulfated polysaccharides is involved in host cell infection. J Biol Chem 1999, 274:1267-1276.
34. He X.L., Grigg M.E., Boothroyd J.C., Garcia K.C. Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily. Nat Struct Biol 2002, 9:606-611.
35. Silverman J.A., Qi H., Riehl A., Beckers C., Nakaar V., Joiner K.A. Induced activation of the Toxoplasma gondii nucleoside triphosphate hydrolase leads to depletion of host cell ATP levels and rapid exit of intracellular parasites from infected cells. J Biol Chem 1998, 273:12352-12359.
36. Donald R.G., Roos D.S. Insertional mutagenesis and marker rescue in a protozoan parasite: cloning of the uracil phosphoribosyltransferase locus from Toxoplasma gondii. Proc Natl Acad Sci USA 1995, 92:5749-5753.
37. Gubbels M.J., Mazumdar J., van Dooren G., Striepen B. Manipulation of the Toxoplasma genome 2007, Horizon Scientific Press, Norwich, UK.
38. Tomita T., Yamada T., Weiss L.M., Orlofsky A. Externally triggered egress is the major fate of Toxoplasma gondii during acute infection. J Immunol 2009, 183:6667-6680.
39. Persson E.K., Agnarson A.M., Lambert H., et al. Death receptor ligation or exposure to perforin trigger rapid egress of the intracellular parasite Toxoplasma gondii. J Immunol 2007, 179:8357-8365.