In vitro expression and characterization of MYH9 mutant alleles linked to hereditary hearing loss

Otolaryngology - Head and Neck Surgery (United States)

Volumn 142, Issue 5, 2010, Pages 699-703

  Wei, Calvin C ^a,b   Lalwani, Anil K ^a,b,c   Mhatre, Anand N ^b,c  

^a Laboratory of Molecular Otology   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Physiology and Neuroscience ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; MUTANT PROTEIN; MYOSIN HEAVY CHAIN; MYOSIN HEAVY CHAIN 9; UNCLASSIFIED DRUG;

ALLELE; AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE REGULATION; CELL SHAPE; CELL STRAIN; CELL STRAIN MDA MB 231; CYTOKINESIS; CYTOSKELETON; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC LINKAGE; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE; IN VITRO GENE TRANSFER; IN VITRO STUDY; PHENOTYPE; SITE DIRECTED MUTAGENESIS; CELL DIVISION; CELL LINE; GENETIC TRANSFECTION; GENETICS; HEARING LOSS; MUTATION;

ALLELES; CELL DIVISION; CELL LINE; CYTOSKELETON; HEARING LOSS; HUMANS; LINKAGE (GENETICS); MUTATION; TRANSFECTION;

EID: 77951907172     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1016/j.otohns.2009.12.030     Document Type: Article

References (10)

1. Simons M, Wang M, McBride OW, et al. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. Circ Res 1991;69:530-9.
2. Toothaker LE, Gonzalez DA, Tung N, et al. Cellular myosin heavy chain in human leukocytes: isolation of 5= cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation. Blood 1991;78:1826-33.
3. Sellers Jr. Myosins: a diverse superfamily. Biochem Biophys Acta 2000;1496:3-22. (Pubitemid 30155594)
4. Hildebrand MS, de Silva MG, Gardner RJ, et al. Cochlear implants for DFNA17 deafness. Laryngoscope 2006;116:2211-5. (Pubitemid 44912319)
5. Lalwani AK, Goldstein JA, Kelley MJ, et al. Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle my-osin MYH9. Am J Hum Genet 2000;67:1121-8.
6. Conti MA, Even-Ram S, Liu C, et al. Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J Biol Chem 2004;279:41263-6. (Pubitemid 39313562)
7. Mhatre AN, Li Y, Bhatia N, et al. Generation and characterization of mice with MYH9 deficiency. Neuromolecular Med 2007;9:205-15. (Pubitemid 350129696)
8. Li Y, Friedmann DR, Mhatre AN, et al. MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function. Cell Motil Cytoskeleton 2008;65:393-405. (Pubitemid 351657154)
9. Dulyaninova NG, House RP, Betapudi V, et al. Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells. Mol Biol Cell 2007;18:3144-55. (Pubitemid 47235318)
10. Zhuravlev PI, Papoian GA. Molecular noise of capping protein binding induces macroscopic instability in filopodial dynamics. Proc Natl Acad Sci USA 2009;106:11570-5.