Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

Biochemical Journal

Volumn 426, Issue 3, 2010, Pages 281-292

  Hurtado Guerrero, Ramon ^a   Zusman, Tal ^b   Pathak, Shalini ^a   Ibrahim, Adel F M ^a   Shepherd, Sharon ^a   Prescott, Alan ^a   Segal, Gil ^b   Van Aalten, Daan M F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Elongation factor 1A (EF1A); Glucosyl transferase; Legionella pneumophila; Microinjection; Protein structure; Site directed mutagenesis

Indexed keywords

ELONGATION FACTOR; GLUCOSYLTRANSFERASES; LEGIONELLA PNEUMOPHILA; MICRO-INJECTION; PROTEIN STRUCTURES; SITE DIRECTED MUTAGENESIS;

BACTERIA; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; COMMINUTION; ELONGATION; ENZYME ACTIVITY; GLUCOSE; INTERNET PROTOCOLS; MACROPHAGES; MUTAGENESIS; PROTEINS; SUBSTRATES;

CRYSTAL STRUCTURE;

ASPARAGINE; ELONGATION FACTOR 1ALPHA; GLYCOSYLTRANSFERASE; VIRULENCE FACTOR; BACTERIAL PROTEIN; ELONGATION FACTOR 1; ISOENZYME; URIDINE DIPHOSPHATE GLUCOSE;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL MIGRATION; CLONING; CRYSTAL STRUCTURE; GLYCOSYLATION; HUMAN; HUMAN CELL; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; MACROPHAGE; MICROINJECTION; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; APOPTOSIS; BINDING SITE; CELL LINE; CELL STRAIN HL 60; CHEMICAL STRUCTURE; CHEMISTRY; CONFOCAL MICROSCOPY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HELA CELL; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

LEGIONELLA PNEUMOPHILA; NEGIBACTERIA;

AMINO ACID SEQUENCE; APOPTOSIS; ASPARAGINE; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; GLYCOSYLTRANSFERASES; HELA CELLS; HL-60 CELLS; HUMANS; ISOENZYMES; LEGIONELLA PNEUMOPHILA; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE ELONGATION FACTOR 1; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; URIDINE DIPHOSPHATE GLUCOSE;

EID: 77951904771     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091351     Document Type: Article

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