Descriptive study on the efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Sudan

European Journal of Clinical Pharmacology

Volumn 66, Issue 3, 2010, Pages 231-237

  Elamin, Sakina Babikir ^a   Awad, Abdelmoneim Ismail ^b   Eltayeb, Idris Babiker ^c   Elmardi, Khalid Abdelmutalab ^a   Al Hassan, Asma Hashim ^a   Mohamed, AbedlRahim Osman ^d   Malik, Elfatih Mohammad ^a   Mohamad, Tarig Abedelgadir ^a  

^a FEDERAL MINISTRY OF HEALTH   (Sudan)

^b KUWAIT UNIVERSITY   (Kuwait)

^c UNIVERSITY OF KHARTOUM   (Sudan)

^d University of El Imam El Mahdi   (Sudan)

Author keywords

Artemether lumefantrine; Plasmodium falciparum; Sudan; Uncomplicated malaria

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE;

ARTICLE; CHILD; DESCRIPTIVE RESEARCH; DIZZINESS; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; FEMALE; FEVER; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NAUSEA; PARASITEMIA; PRIORITY JOURNAL; PRURITUS; SUDAN; TABLET; ADOLESCENT; ADULT; CLINICAL TRIAL; DISEASE TRANSMISSION; DRUG ADMINISTRATION; DRUG COMBINATION; INFANT; MULTICENTER STUDY; NEWBORN; ORAL DRUG ADMINISTRATION; PARASITOLOGY; PRESCHOOL CHILD; TIME; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; ETHANOLAMINES; FEMALE; FEVER; FLUORENES; HUMANS; INFANT; INFANT, NEWBORN; MALARIA, FALCIPARUM; MALE; PARASITEMIA; SUDAN; TABLETS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77951898357     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-009-0750-4     Document Type: Article

References (40)

1. Olliaro PL, Taylor WRJ (2003) Review article antimalarial compound from bench to bedside. J Exp Biol 206:35753-35759
2. Gilles HM (1991) Introduction. In: WHO (ed) A practical handbook in the management of severe and complicated malaria, 2nd edn. World health Organization, Geneva, pp 1-4
3. Malik EM, Khalfalla OM (2004) Malaria in Sudan: past, present and the future. Gezira Journal of Health Sciences I(Suppl):47-51
4. White NJ, Nosten F, Looareesuwan S et al (1999) Averting a malaria disaster. Lancet 353:1965-1967
5. Zucker JR, Ruebush TK, Obonyo C, Otieno J, Campell CC (2003) The mortality consequences of the continued use of chloroquine in Africa: experience in Siaya, westwern Kenya. Am J Trop Med Hyg 68:386-390
6. Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D (2001) High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. J Infect Dis 183(10):1535-1538
7. Adam I, Osman ME, ElGhazali G, Ahmed GI, Gustafson LL, Elbashir MI (2204) Efficacies of chloroquine, sulphadoxinepyrimethamine and quinine for the treatment of uncomplicated Plasmodium falciparum malaria in Eastern Sudan. Ann Trop Med Parasitol 98(7):661-666
8. Salah MT, Mohammed MM, Himeidan YE, Malik EM, Elbashir MI, Adam I (2005) A randomized comparison of sulphadoxinepyrimethamine and combination of sulphadoxine pyrimethamine with chloroquine in the treatment of uncomplicated falciparum malaria in Eastern Sudan. Saudi Med J 26(1):147-148
9. Malik EM, Nour SM, Hamid IK, Elmardi KA, Mohamed TA, Ahmed ES (2005) From home to hospital: Beliefs and practices related to severe malaria in Sudan. J Fam Community Med 12:85-90
10. Ibrahim AM, Ali FR, Ali ME (1992) Assessment of chloroquine resistance of Plasmodium falciparum in children of Wad Medani (Central Sudan). J Trop Pediat 38:162-166
11. Adam I, Ibrahim MH, A/elbasit IA, Elbashir MI (2004) Efficacy of sulfadoxine- pyrimethamine for uncomplicated Plasmodium falciparum malaria in a small sample of Sudanese children. East Mediterr Health J 10:309-314
12. van den Broek IV, Gatkoi T, Lowoko B, Nzila A, Ochong E, Keus K (2003) Chloroquine, sulfadoxine-pyrimethamine and amodiaquine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Upper Nile, south Sudan. Trans R Soc Trop Med Hyg 97 (2):229-235
13. Guerin PJ, Olliaro P, Nosten F et al (2002) Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect Dis 2:564-573 (Pubitemid 34966359)
14. Greenwood BM, Bojang K, Whitty CJ, Targett GA (2005) Malaria. Lancet 365:1487-1498
15. World Health Organization (2006) Global Antimalarial Drug Policies database-AFRO. Antimalarial treatment policies for P. falciparum and P. vivax by country in WHO Africa region. Available Via DIALOG. http://www.who.int/malaria/ amdp/amdp-afro.htm. Accessed 16 May 2009
16. International Artemisinin Study Group (2004) Artesunate combinations for treatment of malaria: meta-analysis. Lancet 363:9-17
17. Malik EM, Mohamed TA, Elmardi KA, Mowien RM, Elhassan AH, Elamin SB, Mannan AA, Ahmed ES (2006) From chloroquine to artemisinin-based combination therapy: the Sudanese experience. Malar J 5:65
18. Adam I, A-Elbasit IE, Idris SM, Malik EM, Elbashir MI (2005) A comparison of the efficacy of artesunate plus sulfadoxinepyrimethamine with that of sulfadoxine-pyrimethamine alone, in the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan. Ann Trop Med Parasitol 9:449-455
19. Hamour S, Melaku Y, Keus K, Wambugu J, Atkin S, Montgomery J, Ford N, Hook C, Checchi F (2005) Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine- pyrimethamine and artesunate plus amodiaquine combinations. Trans R Soc Trop Med Hyg 99:548-554
20. van den Broek I, Amsalu R, Balasegaram M, Hepple P, Alemu E, Hussein el B, Al-Faith M, Montgomery J, Checchi F (2005) Efficacy of two artemisinin combination therapies for uncomplicated falciparum malaria in children under 5 years, Malakal, Upper Nile, Sudan. Malar J 4:14
21. Elamin SB, Malik EM, Abdelgadir T, Khamiss AH, Mohammed MM, Ahmed ES, Adam I (2005) Artesunate plus sulfadoxinepyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan. Malar J 4:41
22. Mohamed AO, Eltaib EH, Ahmed OA, Elamin SB, Malik EM (2006) The efficacies of artesunate-sulfadoxine-pyrimethamine and artemether-lumefantrine in the treatment of uncomplicated, Plasmodium falciparum malaria, in an area of low transmission in central Sudan. Ann Trop Med Parasitol 100:5-10
23. Adam I, A-Elbasit IE, Elbashir MI (2005) Efficacies of mefloquine alone and of artesunate followed by mefloquine, for the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan. Ann Trop Med Parasitol 99:111-117
24. Salah MT, Faroug M, Magzoub MM, Adam I (2006) Efficacy of artemether-lumefantrine (Co-Artesiane®) suspension in the treatment of uncomplicated Plasmodium falciparum malaria among children under 5 years in eastern Sudan. Trop J Pharm Res 5(1):551-555
25. Mukhtar EA, Gadalla NB, El-zaki S-EG, Mukhtar I, Mansour FA, Babiker A, El-Sayed BB (2007) A comparative study on the efficacy of artesunate plus sulphadoxine/pyrimethamine versus artemether-lumefantrine in eastern Sudan. Malar J 6:92
26. World Health Organization (2003) Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. http://apps.who.int/malaria/docs/Protocol WHO.pdf
27. Falade C, Makanga M, Premji Z, Ortmann CE, Stockmeyer M, de Palacios PI (2005) Efficacy and safety of artemether-lumefantrine (Coartem) tablets (six-dose regimen) in African infants and children with acute, uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg 99:459-467
28. Koram KA, Abuaku B, Duah N, Quashie N (2005) Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana. Acta Tropica 95:194-203
29. Jima D, Tesfaye G, Medhin A, Kebede A, Argaw D, Babaniyi O (2005) Safety and efficacy of artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in Ethiopia. East Afr Med J 82:387-390 (Pubitemid 41539862)
30. Mutabingwa TK (2005) Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy! Acta Trop 95:305-315
31. Agnamey P, Brasseur P, Cisse M, Gaye O, Dumoulin J, Rigal J, TaylorWR, Olliaro P (2005) Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunateamodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye District of south-western Senegal. Trop Med Int Health 10:926-933
32. Bjorkman A, Bhattarai A (2005) Public health impact of drug resistant Plasmodium falciparum malaria. Acta Trop 94:163-169
33. Trape JF (2001) The public health impact of chloroquine resistance in Africa. Am J Trop Med Hyg 64:12-17
34. Muheki C, McIntyre D, Barnes KI (2004) Artemisinin-based combination therapy reduces expenditure on malaria treatment in KwaZulu Natal, South Africa. Trop Med Int Health 9:959-966
35. Abdu Z, Mohammed Z, Bashier I, Eriksson B (2004) The impact of user fee exemption on service utilization and treatment seeking behaviour: the case of malaria in Sudan. Int J Health Plann Manage 19:S95-106
36. Whitty CJM, Allan R, Wiseman V, Ochola S et al (2004) Averting a malaria disaster in Africa-where does the buck stop? Bull World Health Organ 82:381-384
37. World Health Organization (2003) Access to antimalarial medicines: Improving the affordability and financing of artemisinin-based combination therapies. http://apps.who.int/malaria/cmc-upload/0/ 000/016/745/37268-ACT- final2.pdf
38. Awad AI, Eltayeb IB (2007) Self-medication practices with antibiotics and antimalarials among Sudanese undergraduate university students. Ann Pharmacother 41(7):1249-1255
39. Awad AI, Eltayeb IB, Capps PAG (2006) Self-medication practices in Khartoum State, Sudan. Eur J Clin Pharmacol 62(4):317-324
40. Awad AI, Eltayeb IB, Matowe L, Thalib L (2005) Self-medication with antibiotics and antimalarials in the community of Khartoum State, Sudan. J Pharm Pharmaceut Sci 8(2):326-331