Principles of Evidence-Based Medicine

Orthopedic Clinics of North America

Volumn 41, Issue 2, 2010, Pages 131-138

  Panesar, Sukhmeet S ^a   Philippon, Marc J ^b   Bhandari, Mohit ^c  

^a NATIONAL PATIENT SAFETY AGENCY   (United Kingdom)

^b Steadman Hawkins Research Foundation   (United Kingdom)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Evidence synthesis; Evidence based medicine; Orthopedics; Statistics

Indexed keywords

CLINICAL COMPETENCE; CLINICAL RESEARCH; CONFIDENCE INTERVAL; DATA BASE; EVIDENCE BASED MEDICINE; ORTHOPEDIC SURGERY; PATIENT SELECTION; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SURGEON; SYSTEMATIC ERROR;

CONFIDENCE INTERVALS; EVIDENCE-BASED MEDICINE; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 77951885427     PISSN: 00305898     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ocl.2009.12.001     Document Type: Review

References (30)

1. Strauss S.E., McAlister F.A. Evidence-based medicine: past, present, and future. Ann R Coll Physicians Surg Can 1999, 32:260-264.
2. Bhandari M. Evidence-based medicine: why bother?. Arthroscopy 2009, 25(3):296-297.
3. Guyatt G.H., Sackett D.L., Sinclair J.C., et al. Users' guides to the medical literature. IX. A method for grading health care recommendations. Evidence-Based Medicine Working Group. JAMA 1995, 274(22):1800-1804.
4. Sackett D.L., Rosenberg W.M., Gray J.A., et al. Evidence based medicine: what it is and what it isn't. BMJ 1996, 312(7023):71-72.
5. Jones R.S., Richards K. Office of Evidence-Based Surgery charts course for improved system of care. Bull Am Coll Surg 2003, 88(4):11-21.
6. Panesar S.S., Thakrar R., Athanasiou T., et al. Comparison of reports of randomized controlled trials and systematic reviews in surgical journals: literature review. J R Soc Med 2006, 99(9):470-472.
7. Haynes R.B. Where's the meat in clinical journals?. ACP J Club 1993, 119:A23-A24.
8. Weiser T.G., Regenbogen S.E., Thompson K., et al. An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet 2008, 372(9633):139-144.
9. Gawande A. Getting there from here: how should Obama reform health care?. New Yorker 2009, 1:26-33.
10. Sung J., Siegel J., Tornetta P., et al. The orthopaedic trauma literature: an evaluation of statistically significant findings in orthopaedic trauma randomized trials. BMC Musculoskelet Disord 2008, 9:14.
11. Chan S., Bhandari M. The quality of reporting of orthopaedic randomized trials with use of a checklist for nonpharmacological therapies. J Bone Joint Surg Am 2007, 89(9):1970-1978.
12. Oxford Centre for Evidence Based Medicine, Available at:, Accessed August 5, 2009. http://www.cebm.net/index.aspx?o=1025.
13. Brozek J.L., Akl E.A., Alonso-Coello P., et al. Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy 2009, 64(5):669-677.
14. Poolman R.W., Petrisor B.A., Marti R.K., et al. Misconceptions about practicing evidence-based orthopedic surgery. Acta Orthop 2007, 78(1):2-11.
15. McCulloch P., Taylor I., Sasako M., et al. Randomised trials in surgery: problems and possible solutions. BMJ 2002, 324(7351):1448-1451.
16. Devereaux P.J., Bhandari M., Clarke M., et al. Need for expertise based randomised controlled trials. BMJ 2005, 330:88.
17. Bednarska E., Bryant D., Devereaux P.J., et al. Orthopaedic surgeons prefer to participate in expertise-based randomized trials. Clin Orthop Relat Res 2008, 466(7):1734-1744.
18. Sprague S., Matta J.M., Bhandari M. Multicenter collaboration in observational research: improving generalizability and efficiency. J Bone Joint Surg Am 2009, 91(Suppl 3):80-86.
19. von Elm E., Altman D.G., Egger M., et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007, 370(9596):1453-1457.
20. Measures of relative effect: the risk ratio and odds ratio. In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions, version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009. Available at: Accessed January 22, 2010. http://www.cochrane-handbook.org.
21. Kocher M.S., Zurakowski D. Clinical epidemiology and biostatistics: a primer for orthopaedic surgeons. J Bone Joint Surg Am 2004, 86(3):607-620.
22. Easterbrook P.J., Berlin J.A., Gopalan R., et al. Publication bias in clinical research. Lancet 1991, 337(8746):867-872.
23. Okike K., Kocher M.S., Mehlman C.T., et al. Publication bias in orthopaedic research: an analysis of scientific factors associated with publication in the Journal of Bone and Joint Surgery (American Volume). J Bone Joint Surg Am 2008, 90(3):595-601.
24. Poolman R.W., Kerkhoffs G.M., Struijs P.A., et al. Don't be misled by the orthopedic literature: tips for critical appraisal. Acta Orthop 2007, 78(2):162-171.
25. Bhandari M., Tornetta P., Ellis T., et al. Hierarchy of evidence: differences in results between non-randomized studies and randomized trials in patients with femoral neck fractures. Arch Orthop Trauma Surg 2004, 124(1):10-16.
26. Dawes M., Summerskill W., Glasziou P., et al. Sicily statement on evidence based practice. BMC Med Educ 2005, 5(1):1.
27. What is the difference between PubMed and MEDLINE? United Stated National Library of Medicine, National Institutes of Health, Available at:, Accessed January 22, 2010. http://www.nlm.nih.gov/pubs/factsheets/dif_med_pub.html.
28. Bhandari M., Guyatt G.H., Swiontkowski M.F. User's guide to the orthopaedic literature: how to use an article about a surgical therapy. J Bone Joint Surg Am 2001, 83(6):916-926.
29. Jones A., Dollery W. Admission not needs for uncomplicated sternal fractures. BESTBets Available at:, Accessed January 22, 2010. http://www.bestbets.org/bets/bet.php?id=5.
30. Principles for best practice in clinical audit National Institute of Health and Clinical Excellence (NICE), Available at:, Accessed January 22, 2010. http://www.nice.org.uk/media/796/23/BestPracticeClinicalAudit.pdf.