Accelerated Partial Breast Irradiation With IMRT: New Technical Approach and Interim Analysis of Acute Toxicity in a Phase III Randomized Clinical Trial

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 2, 2010, Pages 509-515

  Livi, Lorenzo ^a   Buonamici, Fabrizio Banci ^a   Simontacchi, Gabriele ^a   Scotti, Vieri ^a   Fambrini, Massimiliano ^a   Compagnucci, Antonella ^a   Paiar, Fabiola ^a   Scoccianti, Silvia ^a   Pallotta, Stefania ^a   Detti, Beatrice ^a   Agresti, Benedetta ^a   Talamonti, Cinzia ^a   Mangoni, Monica ^a   Bianchi, Simonetta ^a   Cataliotti, Luigi ^a   Marrazzo, Livia ^a   Bucciolini, Marta ^a   Biti, Giampaolo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

accelerated partial breast irradiation; APBI; breast cancer; IMRT; Intensity modulated radiotherapy

Indexed keywords

ACCELERATED PARTIAL BREAST IRRADIATION; ACUTE TOXICITY; BREAST CANCER; BREAST TREATMENT; CLINICAL TARGET VOLUMES; CLINICAL TRIAL; CONTRALATERAL BREAST; EARLY-STAGE BREAST CANCER; INTENSITY-MODULATED RADIOTHERAPY; INTERNAL QUALITY; INTERNATIONAL COMMISSION; MEAN VALUES; ORGANS AT RISKS; PLANNING TARGET VOLUMES; PRELIMINARY ANALYSIS; RADIATION THERAPY ONCOLOGY GROUPS; RADIATION UNIT; RANDOMIZED CLINICAL TRIALS; REGIONS OF INTEREST; SKIN TOXICITY; SPINAL CORDS; SURGICAL CLIPS; THREE DIMENSIONS;

EXPERIMENTS; FLOW PATTERNS; IRRADIATION; MEDICAL APPLICATIONS; PHYSICAL THERAPY; QUALITY ASSURANCE; QUALITY CONTROL; RADIATION; TARGETS; TOTAL QUALITY MANAGEMENT; TOXICITY;

RADIOTHERAPY;

ADULT; ARTICLE; BREAST CANCER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; INTENSITY MODULATED RADIATION THERAPY; INTERMETHOD COMPARISON; IRRADIATION; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; QUALITY CONTROL; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; RADIATION SICKNESS; RANDOMIZED CONTROLLED TRIAL; SKIN TOXICITY;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; FEASIBILITY STUDIES; FEMALE; HUMANS; RADIATION INJURIES; RADIOTHERAPY, INTENSITY-MODULATED; TUMOR BURDEN;

EID: 77951869767     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.04.070     Document Type: Article

References (35)

1. Veronesi U., Saccozzi R., Del V., et al. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 305 (1981) 6-11
2. Liljegren G., Holmberg J., Bergh A., et al. 10-Year result after sector resection with or without postoperative radiotherapy for stage I breast cancer: A randomized trial. J Clin Oncol 17 (1999) 2326-2333
3. Fisher B., Anderson S., Redmod C.K., et al. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med 333 (1995) 1456-1461
4. Bartelink H., Horiot J.C., Poortmans H., et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 345 (2001) 1378-1387
5. Athas W.F., Adams-Cameron M., Hunt W.C., et al. Travel distance to radiation therapy and receipt of radiotherapy following breast-conserving surgery. J Natl Cancer Inst 92 (2000) 269-271
6. Veronesi U., Luini A., Del Vecchio M., et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med 328 (1993) 1587-1591
7. Fisher E.R., Anderson S., Redmond C., et al. Ipsilateral breast tumour recurrence and survival following lumpectomy and irradiation: Pathological findings from NSABP protocol B-06. Semin Surg Oncol 8 (1992) 161-166
8. Vaidja J.S., and Baum M. Clinical and biological implications of the Milan breast conservation trials. Eur J Cancer 34 (1998) 1143-1144
9. Bensaleh S., Bezak E., and Borg M. Review of MammoSite brachytherapy: Advantages, disadvantages and clinical outcomes. Acta Oncol 22 (2008) 1-8
10. Ivaldi G.B., Leonardi M.C., Orecchia R., et al. Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women. Int J Radiat Oncol Biol Phys 72 (2008) 485-493
11. Vicini F.A., Baglan K.L., Kestin L.L., et al. Accelerated treatment of breast cancer. J Clin Oncol 19 (2001) 1993-2001
12. Livi L., Paiar F., Buonamici F.B., et al. Accelerated intensity-modulated external radiotherapy as a new technical approach to treat the index quadrant after conserving surgery in early breast cancer: A preliminary study. Tumori 91 (2005) 227-232
13. Miften M., Wiesmeyer M., Monthofer S., et al. Implementation of FFT convolution and multigrid superposition models in the FOCUS RTP system. Phys Med Biol 45 (2000) 817-833
14. Bucciolini M., Banci Buonamici F., and Casati M. Verification of IMRT fields by film dosimetry. Med Phys 31 (2004) 161-168
15. Banci Buonamici F., Compagnucci A., Marrazzo L., et al. An intercomparison between diode matrix and film for IMRT quality assurance. Med Phys 34 (2007) 1372-1379
16. Corry J., Hope G., and Cramb J. Intensity-modulated radiation therapy: First reported treatment in Australasia. Australas Radiol 46 (2002) 285-289
17. Zhen W., Thompson R.B., and Enke C.A. Intensity-modulated radiation therapy (IMRT): The radiation oncologist's perspective. Med Dosim 27 (2002) 155-159
18. Martin S., Mannino M., Rostom A., et al. Acute toxicity and 2-year adverse effects of 30 Gy in five fractions over 15 days to whole breast after local excision of early breast cancer. Clin Oncol (R Coll Radiol) 20 (2008) 502-505
19. Jones B., Dale R.G., Deehan C., et al. The role of biologically effective dose (BED) in clinical oncology. Clin Oncol 13 (2001) 71-81
20. Dale R.G., and Jones B. The assessment of RBE effects using the concept of biologically effective dose. Int J Radiat Oncol Biol Phys 43 (1999) 639-645
21. Lee S.P., Leu M.Y., Smathers J.B., et al. Biologically effective dose distribution based on the linear quadratic model and its clinical relevance. Int J Radiat Oncol Biol Phys 33 (1995) 375-389
22. Antonucci J.V., Wallace M., Goldstein N.S., et al. Differences in patterns of failure in patients treated with accelerated partial breast irradiation versus whole-breast irradiation: A matched-pair analysis with 10-year follow-up. Int J Radiat Oncol Biol Phys 74 (2009) 447-452
23. Major T., Niehoff P., Kovacs G., et al. Dosimetric comparisons between high dose rate interstitial and MammoSite balloon brachytherapy for breast cancer. Radiother Oncol 79 (2006) 321-328
24. Fentiman I.S., Poole C., Tong D., et al. Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer 32A (1996) 608-611
25. Vicini F., Kini V.R., Chen P., et al. Irradiation of the tumor bed alone after lumpectomy in selected patients with early-stage breast cancer treated with breast conserving therapy. J Surg Oncol 70 (1999) 33-40
26. Kestin L.L., Jaffray D.A., Edmundson G.K., et al. Improving the dosimetric coverage of interstitial high-dose-rate breast implants. Int J Radiat Oncol Biol Phys 46 (2000) 35-43
27. Bensaleh S., Bezak E., and Borg M. Review of MammoSite brachytherapy: Advantages, disadvantages and clinical outcomes. Acta Oncol 22 (2008) 1-8
28. Benitez P.R., Keisch M.E., and Vicini F. Five-year results: The initial clinical trial of MammoSite balloon brachytherapy for partial breast irradiation in early-stage breast cancer. Am J Surg 194 (2007) 456-462
29. Haley M., Beriwal S., and Heron D.E. MammoSite accelerated partial breast irradiation: A single-institution outcomes analysis with 2 years of followup. Brachytherapy 8 (2009) 9-13
30. Ivaldi G.B., Leonardi M.C., Orecchia R., et al. Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women. Int J Radiat Oncol Biol Phys 72 (2008) 485-493
31. Hermanto U., Frija E.K., and Lii M.J. Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: Does IMRT increase the integral dose to normal brain?. Int J Radiat Oncol Biol Phys 67 (2007) 1135-1144
32. Purdy J.A. Dose to normal tissues outside the radiation therapy patient's treated volume: A review of different radiation therapy techniques. Health Phys 95 (2008) 666-676
33. Moon S.H., Shin K.H., Kim T.H., et al. Dosimetric comparison of four different external beam partial breast irradiation techniques: Three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, helical tomotherapy, and proton beam therapy. Radiother Oncol 90 (2009) 66-73
34. Vicini F., Arthur D., Polgar C., et al. Defining the efficacy of accelerated partial breast irradiation: The importance of proper patient selection, optimal quality assurance, and common sense. Int J Radiat Biol Phys 57 (2003) 1210-1213
35. Buchholz T.A. Partial breast irradiation-Is it ready for prime time?. Int J Radiat Biol Phys 57 (2003) 1214-1216