Tolerance to apomorphine develops and reverses rapidly

Movement Disorders

Volumn 25, Issue 6, 2010, Pages 803-804

  Gancher, Stephen ^a   Nutt, John ^b  

^a KAISER PERMANENTE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOMORPHINE; DOPAMINE RECEPTOR;

BOLUS INJECTION; DOPAMINERGIC SYSTEM; DRUG INFUSION; DRUG MECHANISM; DRUG TOLERANCE; HUMAN; LETTER; NEUROLOGIC DISEASE; PARKINSON DISEASE; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; TREATMENT RESPONSE;

EID: 77951853597     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23036     Document Type: Letter

References (3)

1. Vaamonde J, Flores MH, Weisser R, Ibanez R, Obeso JA. The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease. Mov Disord 2009;24:762-765.
2. Gancher ST, Nutt JG, Woodward WR. Time course of tolerance to apomorphine in parkinsonism. Clin Pharmacol Ther 1992;52:504-510.
3. Grandas F, Gancher S, Lera G, et al. Time interval between repeated injections conditions the duration of motor improvement to apomorphine in Parkinson's disease. Neurology 1992;42:1287-1290.