Was the preterm birth rate in the placebo group too high in the Meis MFMU Network trial of 17-OHPC?

American Journal of Obstetrics and Gynecology

Volumn 202, Issue 5, 2010, Pages 409-410

  Iams, Jay D ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASTOR OIL; HYDROXYPROGESTERONE CAPROATE; OMEGA 3 FATTY ACID; PLACEBO;

AFRICAN AMERICAN; CLINICAL TRIAL; DEMOGRAPHY; EDITORIAL; ETHNIC DIFFERENCE; GESTATIONAL AGE; HUMAN; LOW BIRTH WEIGHT; OBSTETRICS; POPULATION RISK; PREMATURITY; PRIORITY JOURNAL; RECURRENCE RISK; RECURRENT DISEASE; RISK FACTOR; RISK REDUCTION; VITAMIN SUPPLEMENTATION;

17-ALPHA-HYDROXYPROGESTERONE; CASTOR OIL; FEMALE; HUMANS; OXYTOCIN; PREGNANCY; PREGNANCY TRIMESTER, THIRD; PREMATURE BIRTH; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECURRENCE; RISK ASSESSMENT; RISK FACTORS; UTERINE CONTRACTION;

EID: 77951816755     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2010.03.020     Document Type: Editorial

References (15)

1. Meis P.J., Klebanoff M., Thom E., et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 348 (2003) 2379-2385
2. Greene M.F. Progesterone and preterm delivery-déjà vu all over again. N Engl J Med 348 (2003) 2453-2455
3. Thornton J.G. Progesterone and preterm labor-still no definite answers. N Engl J Med 357 (2007) 499-501
4. Iams J.D., Newman R.B., Thom E., et al. Frequency of uterine contractions and the risk of spontaneous preterm delivery. N Engl J Med 346 (2002) 250-255
5. Brancazio L.R., Murtha A.P., and Heine R.P. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 349 (2003) 1087
6. Meis P.J., and Spong C.Y. Reply to Brancazio et al, ibid. N Engl J Med 349 (2003) 1087-1088
7. O'Sullivan M.D., Hehir M.P., O'Brien Y.M., and Morrison J.J. 17 alpha-hydroxyprogesterone caproate vehicle, castor oil, enhances the contractile effect of oxytocin in human myometrium in pregnancy. Am J Obstet Gynecol 202 (2010) 453.e1-453.e4
8. Mercer B.M., Goldenberg R.L., Moawad A., et al. The preterm prediction study: effect of gestational age and cause of PTB on subsequent pregnancy outcome. Am J Obstet Gynecol 181 (1999) 1216-1221
9. Martin J.A., Hamilton B.E., and Sutton P.D. Births: final data for 2005. National vital statistics reports. Vol 56. No 6 (2007), National Center for Health Statistics, Hyattsville, MD
10. Adams M.M., Elam-Evans L.D., Wilson H.G., et al. Rates of and factors associated with recurrence of preterm delivery. JAMA 283 (2000) 1591-1596
11. Kistka Z.A.F., Palomar L., Lee K.A., et al. Racial disparity in the frequency of recurrence of PTB. Am J Obstet Gynecol 196 (2007) 131.e1-131.e6
12. McManemy J., Cooke E., Amon E., et al. Recurrence risk for preterm delivery. Am J Obstet Gynecol 196 (2007) 576.e1-576.e6
13. Harper M., Thom E., Klebanoff M.A., et al. Omega-3 fatty acid supplementation to prevent recurrent preterm birth. Obstet Gynecol 115; (2010) 234-242
14. Kaltreider D.F., and Kohl S. Epidemiology of preterm delivery. Clin Obstet Gynecol 23 (1980) 17-31
15. Hauth J.C., Gilstrap III L.C., Brekken A., and Hauth J.M. The effect of 17 alpha-hydroxyprogesterone caproate on pregnancy outcome in an active-duty military population. Am J Obstet Gynecol 146 (1983) 187-190