Refractory cytopenia with unilineage dysplasia: Analysis of prognostic factors and survival in 126 patients

Leukemia and Lymphoma

Volumn 51, Issue 5, 2010, Pages 783-788

  Breccia, Massimo ^a   Latagliata, Roberto ^a   Cannella, Laura ^a   Carmosino, Ida ^a   Santopietro, Michelina ^a   Loglisci, Giuseppina ^a   Federico, Vincenzo ^a   Alimena, Giuliana ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Myelodysplastic syndromes; Survival; WHO

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGE DETERMINATION; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER INCIDENCE; CANCER SURVIVAL; CONTROLLED STUDY; CYTOGENETICS; DISEASE COURSE; ERYTHROCYTE TRANSFUSION; FEMALE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MYELODYSPLASTIC SYNDROME; NEUTROPHIL COUNT; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; REFRACTORY ANEMIA; REFRACTORY CYTOPENIA WITH UNILINEAGE DYSPLASIA; REFRACTORY NEUTROPENIA; REFRACTORY THROMBOCYTOPENIA; RETROSPECTIVE STUDY; SCORING SYSTEM; SEX DETERMINATION; SYMPTOMATOLOGY; THROMBOCYTE COUNT; WORLD HEALTH ORGANIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA, REFRACTORY; BONE MARROW; CELL LINEAGE; FEMALE; HUMANS; KARYOTYPING; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; NEOPLASM STAGING; NEUTROPENIA; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; THROMBOCYTOPENIA; YOUNG ADULT;

EID: 77951812635     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428191003682759     Document Type: Article

References (22)

1. Harris NL, Jaffe ES, Diebold J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. J Clin Oncol 1999;17:3835-3849.
2. Lee JH, Lee JH, Shin YR, et al. Application of different prognostic scoring systems and comparison of the FAB and WHO classifications in Korean patients with myelodysplastic syndrome. Leukemia 2003;17:305-313.
3. Cermák J, Belicková M, Krejcová H, et al. The presence of clonal cell subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with refractory anemia may reflect a multistep pathogenesis of myelodysplasia. Leuk Res 2005;29:371-379.
4. Knipp S, Strupp C, Gattermann N, et al. Presence of peripheral blasts in refractory anemia and refractory cytopenia with multilineage dysplasia predicts an unfavourable outcome. Leuk Res 2008;32:33-37.
5. Breccia M, Carmosino I, Biondo F, et al. Usefulness and prognostic impact on survival of WHO reclassification in FAB low risk myelodyplastic syndromes. Leuk Res 2006;30:178-182.
6. Bennett JM, Catowsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51:189-199.
7. Malcovati L, Porta MG, Pascutto C, et al. Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making. J Clin Oncol 2005;23:7594-7603.
8. Müller-Berndorff H, Haas PS, Kunzmann R, Schulte-Mönting J, Lübert M. Comparison of five prognostic scoring systems, the French-American-British (FAB) and World Health Organization (WHO) classifications in patients with myelodysplastic syndromes: results of a single-center analysis. Ann Hematol 2006;85:502-513.
9. Greenberg P, Cox C, Le Beau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997;89:2079-2088.
10. Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009;114:937-951.
11. Mitelman F, editor. ISCN: an international system for human cytogenetic nomenclature. Basel: Karger; 1995.
12. Mufti GJ, Stevens JR, Oscier DG, Hamblin TJ, Machin D. Myelodysplastic syndromes: a scoring system with prognostic significance. Br J Haematol 1985;59:425-433.
13. Sanz GF, Sanz MA, Vallespi T, et al. Two regression models and scoring system for predicting survival and planning treatment in myelodysplastic syndromes. A multivariate analysis of prognostic factors in 370 patients. Blood 1989;74:395-408.
14. Malcovati L, Germing U, Kuendgen A, et al. Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol 2007;25:3503-3510.
15. Rosati S, Mick R, Xu F, et al. Refractory cytopenia with multilineage dysplasia: further characterization of an 'unclassifiable' myelodysplastic syndrome. Leukemia 1996;10:20-26.
16. Matsuda A, Jinnai I, Yagasaki F, et al. Refractory anemia with severe dysplasia: clinical significance of morphological features in refractory anemia. Leukemia 1998;12:482-485.
17. Nösslinger T, Reisner R, Koller E, et al. Myelodysplastic syndromes, from French-American-British to World Health Organization: comparison of classifications on 431 unselected patients from a single institution. Blood 2001;98:2935-2941.
18. Dunkley SM, Manoharan A, Kwan YL. Myelodysplastic syndromes: prognostic significance of multilineage dysplasia in patients with refractory anemia or refractory anemia with ringed sideroblasts. Blood 2002;99:3870-3871.
19. Cermák J, Vítek A, Michalová K. Combined stratification of refractory anemia according to both WHO and IPSS criteria has a prognostic impact and improves identification of patients who may benefit from stem cell transplantation. Leuk Res 2004;28:551-557.
20. Germing U, Gattermann N, Strupp C, Aivaado M, Aul C. Validation of the WHO proposals for a new classification of primary myelodysplastic syndromes: a retrospective analysis of 1600 patients. Leuk Res 2000;24:983-992.
21. Germing U, Strupp C, Kuendgen A, et al. Prospective validation of the WHO proposals for the classification of myelodysplastic syndromes. Haematologica 2006;91:1596-1604.
22. Verburgh E, Achten R, Louw VJ, et al. A new disease categorization of low-grade myelodysplastic syndromes based on the expression of cytopenia and dysplasia in one versus more than one lineage improves on the WHO classification. Leukemia 2007;21:668-677.