Does respiratory sinus arrhythmia serve a buffering role for diastolic pressure fluctuations?

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 5, 2010, Pages

  Tan, Can Ozan ^a   Taylor, J Andrew ^a  

^a and Red Sox Foundation and Massachusetts General Hospital Home Base Program   (United States)

Author keywords

Atropine; Baroreflex; Diastolic blood pressure; R R interval

Indexed keywords

ATROPINE;

ADULT; ARTICLE; BREATHING; COMPETITIVE INHIBITION; DIASTOLIC BLOOD PRESSURE; FEEDBACK SYSTEM; FEMALE; HEART RHYTHM; HUMAN; MALE; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RESPIRATORY SINUS ARRHYTHMIA; RR INTERVAL; SUPINE POSITION;

ADULT; ANIMALS; ARRHYTHMIA, SINUS; ATROPINE; BAROREFLEX; BLOOD PRESSURE; DATA INTERPRETATION, STATISTICAL; DIASTOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; HUMANS; MALE; MUSCARINIC ANTAGONISTS; REGRESSION ANALYSIS; RESPIRATORY MECHANICS; VAGUS NERVE; YOUNG ADULT;

EID: 77951796760     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00974.2009     Document Type: Article

References (46)

1. Akselrod S, Gordon D, Madwed JB, Snidman NC, Shannon DC, Cohen RJ. Hemodynamic regulation: investigation by spectral analysis. Am J Physiol Heart Circ Physiol 249: H867-H875, 1985. (Pubitemid 16207232)
2. Averill KH, Lamb LE. Less commonly recognized actions of atropine on cardiac rhythm. Am J Med Sci 237: 304-318, 1959.
3. Baselli G, Cerutti S, Civardi S, Malliani A, Pagani M. Cardiovascular variability signals: towards the identification of a closed-loop model of the neural control mechanisms. IEEE Trans Biomed Eng 35: 1033-1046, 1988. (Pubitemid 19029912)
4. Cooke WH, Hoag JB, Crossman AA, Kuusela TA, Tahvanainen KU, Eckberg DL. Human responses to upright tilt: a window on central autonomic integration. J Physiol 517: 617-628, 1999.
5. Cowley AW Jr, Liard JF, Guyton AC. Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res 32: 564-576, 1973.
6. deBoer RW, Karemaker JM, Strackee J. Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol Heart Circ Physiol 253: H680-H689, 1987.
7. Eckberg DL. The human respiratory gate. J Physiol 548: 339-352, 2003.
8. Eckberg DL. Point:Counterpoint: respiratory sinus arrhythmia is due to a central mechanism vs. respiratory sinus arrhythmia is due to the baroreflex mechanism. J Appl Physiol 106: 1740-1742, 2009.
9. Epstein AE, Hirschowitz BI, Kirklin JK, Kirk KA, Kay GN, Plumb VJ. Evidence for a central site of action to explain the negative chronotropic effect of atropine: studies on the human transplanted heart. J Am Coll Cardiol 15: 1610-1617, 1990.
10. Fouad FM, Tarazi RC, Ferrario CM, Fighaly S, Alicandri C. Assessment of parasympathetic control of heart rate by a noninvasive method. Am J Physiol Heart Circ Physiol 246: H838-H842, 1984.
11. Guz A, Innes JA, Murphy K. Respiratory modulation of left ventricular stroke volume in man measured using pulsed Doppler ultrasound. J Physiol 393: 499-512, 1987. (Pubitemid 18046959)
12. Hedman AE, Hartikainen JE, Tahvanainen KU, Hakumaki MO. Power spectral analysis of heart rate and blood pressure variability in anaesthetized dogs. Acta Physiol Scand 146: 155-164, 1992.
13. Ito CS, Scher AM. Regulation of arterial blood pressure by aortic baroreceptors in the unanesthetized dog. Circ Res 42: 230-236, 1978. (Pubitemid 8278073)
14. Japundzic N, Grichois ML, Zitoun P, Laude D, Elghozi JL. Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers. J Auton Nerv Syst 30: 91-100, 1990. (Pubitemid 20192822)
15. Karemaker JM. Counterpoint: respiratory sinus arrhythmia is due to the baroreflex mechanism. J Appl Physiol 106: 1742-1743, 2009.
16. Katona PG, Jih F. Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control. J Appl Physiol 39: 801-805, 1975.
17. Katona PG, Lipson D, Dauchot PJ. Opposing central and peripheral effects of atropine on parasympathetic cardiac control. Am J Physiol Heart Circ Physiol 232: H146-H151, 1977. (Pubitemid 8077514)
18. Keyl C, Dambacher M, Schneider A, Passino C, Wegenhorst U, Bernardi L. Cardiocirculatory coupling during sinusoidal baroreceptor stimulation and fixed-frequency breathing. Clin Sci (Lond) 99: 113-124, 2000. (Pubitemid 30614379)
19. Koizumi K, Terui N, Kollai M. Effect of cardiac vagal and sympathetic nerve activity on heart rate in rhythmic fluctuations. J Auton Nerv Syst 12: 251-259, 1985. (Pubitemid 15145715)
20. Kollai M, Jokkel G, Bonyhay I, Tomcsanyi J, Naszlady A. Relation between baroreflex sensitivity and cardiac vagal tone in humans. Am J Physiol Heart Circ Physiol 266: H21-H27, 1994. (Pubitemid 2045720)
21. Kottmeier CA, Gravenstein JS. The parasympathomimetic activity of atropine and atropine methylbromide. Anesthesiology 29: 1125-1133, 1968.
22. Lipman RD, Salisbury JK, Taylor JA. Spontaneous indices are inconsistent with arterial baroreflex gain. Hypertension 42: 481-487, 2003.
23. Ludwig C. zur Kenntniss des Einflusses der Respirations bewegungen auf den Blutlauf im Aortensysteme. Arch Anat Physiol Leipzig 13: 242-302, 1847.
24. O'Regan RG, Majcherczyk S. Role of peripheral chemoreceptors and central chemosensitivity in the regulation of respiration and circulation. J Exp Biol 100: 23-40, 1982.
25. Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 59: 178-193, 1986. (Pubitemid 16017873)
26. Parker P, Celler BG, Potter EK, McCloskey DI. Vagal stimulation and cardiac slowing. J Auton Nerv Syst 11: 226-231, 1984.
27. Piepoli M, Sleight P, Leuzzi S, Valle F, Spadacini G, Passino C, Johnston J, Bernardi L. Origin of respiratory sinus arrhythmia in conscious humans. An important role for arterial carotid baroreceptors. Circulation 95: 1813-1821, 1997.
28. Raczkowska M, Eckberg DL, Ebert TJ. Muscarinic cholinergic receptors modulate vagal cardiac responses in man. J Auton Nerv Syst 7: 271-278, 1983. (Pubitemid 13098310)
29. Rimoldi O, Pierini S, Ferrari A, Cerutti S, Pagani M, Malliani A. Analysis of short-term oscillations of R-R and arterial pressure in conscious dogs. Am J Physiol Heart Circ Physiol 258: H967-H976, 1990. (Pubitemid 20155537)
30. Robinson BF, Epstein SE, Beiser GD, Braunwald E. Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ Res 19: 400-411, 1966.
31. Shade RE, Bishop VS, Haywood JR, Hamm CK. Cardiovascular and neuroendocrine responses to baroreceptor denervation in baboons. Am J Physiol Regul Integr Comp Physiol 258: R930-R938, 1990. (Pubitemid 20155593)
32. Sharabi Y, Dendi R, Holmes C, Goldstein DS. Baroreflex failure as a late sequela of neck irradiation. Hypertension 42: 110-116, 2003. (Pubitemid 36842244)
33. Shykoff BE, Naqvi SS, Menon AS, Slutsky AS. Respiratory sinus arrhythmia in dogs. Effects of phasic afferents and chemostimulation. J Clin Invest 87: 1621-1627, 1991.
34. St. Croix CM, Satoh M, Morgan BJ, Skatrud JB, Dempsey JA. Role of respiratory motor output in within-breath modulation of muscle sympathetic nerve activity in humans. Circ Res 85: 457-469, 1999. (Pubitemid 29409622)
35. Tang X, Dworkin BR. The dmNTS is not the source of increased blood pressure variability in baroreflex denervated rats. Auton Neurosci 148: 21-27, 2009.
36. Tank J, Baevski RM, Fender A, Baevski AR, Graves KF, Ploewka K, Weck M. Reference values of indices of spontaneous baroreceptor reflex sensitivity. Am J Hypertens 13: 268-275, 2000. (Pubitemid 30206949)
37. Task Force. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93: 1043-1065, 1996.
38. Taylor JA, Eckberg DL. Fundamental relations between short-term RR interval and arterial pressure oscillations in humans. Circulation 93: 1527-1532, 1996.
39. Taylor JA, Myers CW, Halliwill JR, Seidel H, Eckberg DL. Sympathetic restraint of respiratory sinus arrhythmia: implications for vagal-cardiac tone assessment in humans. Am J Physiol Heart Circ Physiol 280: H2804-H2814, 2001. (Pubitemid 32553324)
40. Timmers HJ, Karemaker JM, Lenders JW, Wieling W. Baroreflex failure following radiation therapy for nasopharyngeal carcinoma. Clin Auton Res 9: 317-324, 1999.
41. Timmers HJ, Karemaker JM, Wieling W, Kaanders JH, Folgering HT, Marres HA, Lenders JW. Arterial baroreflex and peripheral chemoreflex function after radiotherapy for laryngeal or pharyngeal cancer. Int J Radiat Oncol Biol Phys 53: 1203-1210, 2002. (Pubitemid 34787856)
42. Timmers HJ, Wieling W, Karemaker JM, Lenders JW. Denervation of carotid baro- and chemoreceptors in humans. J Physiol 553: 3-11, 2003. (Pubitemid 37483911)
43. Tzeng YC, Larsen PD, Galletly DC. Effects of hypercapnia and hypoxemia on respiratory sinus arrhythmia in conscious humans during spontaneous respiration. Am J Physiol Heart Circ Physiol 292: H2397-H2407, 2007.
44. Virtanen R, Kanto J, Iisalo E, Iisalo EU, Salo M, Sjovall S. Pharmacokinetic studies on atropine with special reference to age. Acta Anaesthesiol Scand 26: 297-300, 1982. (Pubitemid 12039115)
45. Yasuma F, Hayano J. Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs. Am J Physiol Heart Circ Physiol 280: H2336-H2341, 2001. (Pubitemid 32433816)
46. Yasuma F, Hayano JI. Impact of acute hypoxia on heart rate and blood pressure variability in conscious dogs. Am J Physiol Heart Circ Physiol 279: H2344-H2349, 2000.