Immunoassay demonstration using a local evanescent array coupled biosensor

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7559, Issue , 2010, Pages

  Yan, Rongjin ^a   Kingry, Luke C ^b   Slayden, Richard A ^b   Lear, Kevin L ^a  

^a Engineering Research Center and Hydraulics Laboratory   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Biosensor; CMOS; Evanescent field; Immunoassay; Integrated detector array; Optical silicon based waveguide

Indexed keywords

EVANESCENT FIELDS; IMMUNOASSAY; INTEGRATED DETECTOR ARRAY; INTEGRATED DETECTORS; SILICON-BASED;

ANTIBODIES; ANTIGENS; BIOASSAY; CMOS INTEGRATED CIRCUITS; DETECTORS; IMMUNOLOGY; IMMUNOSENSORS; METALLIC COMPOUNDS; MOS DEVICES; OPTICAL FIBERS; OPTICAL MATERIALS; POLYSILICON; REFRACTIVE INDEX; SEMICONDUCTING SILICON; SILICON NITRIDE; SURFACE PLASMON RESONANCE; WAVEGUIDES;

BIOSENSORS;

EID: 77951791704     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.842201     Document Type: Conference Paper

References (15)

1. M. Weisser, G. Tovar, S. Mittler-Neher, W. Knoll, F. Brosinger, H. Freimuth, M. Lacher, and W. Ehrfeld, "Specific bio-recognition reactions observed with an integrated Mach-Zehnder interferometer," Biosensors and Bioelectronics, vol. 14, pp. 405-411 (1999).
2. R.G. Heideman and P.V. Lambeck, "Remote opto-chemical sensing with extreme sensitivity: design, fabrication and performance of a pigtailed integrated optical phase-modulated Mach-Zehnder interferometer system," Sensors and Actuators B: Chemical, vol. 61, pp. 100-127 (1999).
3. R. Horváth, H.C. Pedersen, N. Skivesen, D. Selmeczi, and N.B. Larsen, "Optical waveguide sensor for on-line monitoring of bacteria," Optics Letters, vol. 28, pp. 1233-5 (2003).
4. M. Lee and P. Fauchet, "Two-dimensional silicon photonic crystal based biosensing platform for protein detection," Optics Express, vol. 15, p. 4530 (2007).
5. M. Malmqvist, "Biospecific interaction analysis using biosensor technology," Nature, vol. 361, pp. 186-187 (1993).
6. R.D. Harris and J.S. Wilkinson, "Waveguide surface plasmon resonance sensors," Sensors and Actuators B: Chemical, vol. 29, pp. 261-267 (1995).
7. J. Rooney and E. Hall, "Designing a curved surface SPR device," Sensors and Actuators B: Chemical, vol. 114, pp. 804-811 (2006).
8. R.W. Boyd and J.E. Heebner, "Sensitive disk resonator photonic biosensor," Applied Optics, vol. 40, pp. 5742-5747 (2001).
9. K. De Vos, I. Bartolozzi, E. Schacht, P. Bienstman, and R. Baets, "Silicon-on-Insulator microring resonator for sensitive and label-free biosensing," Optics Express, vol. 15, pp. 7615, 7610 (2007).
10. M. Sumetsky, R. Windeler, Y. Dulashko, and X. Fan, "Optical liquid ring resonator sensor," Opt. Express, vol. 15, pp. 14381, 14376 (2007).
11. N.M. Hanumegowda, C.J. Stica, B.C. Patel, I. White, and X. Fan, "Refractometric sensors based on microsphere resonators," Applied Physics Letters, vol. 87, pp. 201107-3 (2005).
12. GW. Yuan, M. Stephens, D. Dandy, and K. Lear, "Direct imaging of transient interference in a single-mode waveguide using near-field scanning optical microscopy," Photonics Technology Letters, IEEE, vol. 17, pp. 2382-2384 (2005).
13. RJ. Yan, GW. Yuan, M.D. Stephens, X. He, C.S. Henry, D.S. Dandy, and K.L. Lear, "Evanescent field response to immunoassay layer thickness on planar waveguides," Applied Physics Letters, vol. 93, pp. 101110-101113 (2008).
14. RJ. Yan, S.P. Mestas, G. Yuan, R. Safaisini, D.S. Dandy, and K.L. Lear, "Label-free silicon photonic biosensor system with integrated detector array," Lab on a Chip, vol. 9, pp. 2163-2168 (2009).
15. RJ. Yan , S.P. Mestas, G. Yuan, R. Safaisini, and K.L. Lear, "Response of Local Evanescent Array-Coupled Biosensors to Organic Nanofilms," Selected Topics in Quantum Electronics, IEEE Journal of, vol. 15, pp. 1469-1477 (2009).