Calcium-alkali syndrome-like symptoms manifested by daily alphacalcidol and thiazide

Internal Medicine

Volumn 49, Issue 9, 2010, Pages 837-840

  Satoh, Fumie ^a   Okado, Tomokazu ^a   Iwamoto, Mari ^a   Akita, Wataru ^a   Wakabayashi, Mai ^a   Ohta, Akihito ^a   Sohara, Eisei ^a   Noda, Yumi ^a   Rai, Tatemitsu ^a   Uchida, Shinichi ^a   Sasaki, Sei ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Alphacalcidol; Calcium alkali syndrome; Hypercalcemia; Metabolic alkalosis; Milk alkali syndrome; Thiazides

Indexed keywords

ALFACALCIDOL; ALKALI; CALCIUM; HYDROCHLOROTHIAZIDE; LISINOPRIL; THIAZIDE DIURETIC AGENT;

ADULT; ANAMNESIS; ARTICLE; CALCIUM ALKALI SYNDROME; CASE REPORT; CLINICAL FEATURE; DISEASE DURATION; DRUG WITHDRAWAL; HUMAN; HYPERCALCEMIA; HYPERTENSION; HYPOPHARYNX CARCINOMA; HYPOVOLEMIA; INTRAVENOUS ADMINISTRATION; KIDNEY INJURY; MALE; METABOLIC ALKALOSIS; MILK ALKALI SYNDROME; NOMENCLATURE; PARESTHESIA; THROAT SURGERY; TREATMENT RESPONSE; WEAKNESS;

AGED; BLOOD CHEMICAL ANALYSIS; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FOLLOW-UP STUDIES; HUMANS; HYDROCHLOROTHIAZIDE; HYDROXYCHOLECALCIFEROLS; HYPERCALCEMIA; KIDNEY FAILURE, ACUTE; KIDNEY FUNCTION TESTS; MALE; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 77951760592     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.49.2601     Document Type: Article

References (24)

1. Hardt LL, Rivers AB. Toxic manifestations following the alkaline treatment of peptic ulcer. Arch Intern Med 31: 171-180, 1923.
2. Orwoll ES. The milk-alkali syndrome: current concepts. Ann Intern Med 97: 242-248, 1982.
3. Medarov BI. Milk-alkali syndrome. Mayo Clin Proc 84: 261-267, 2009.
4. Jamieson MJ. Hypercalcemia. Br Med J (Clin Res Ed) 290: 378-382, 1985.
5. Grundfast MB, Still CD, Komar MJ. Hypercalcemia and peptic ulcer disease-related milk-alkali syndrome. Nutr Clin Pract 18: 250-252, 2003.
6. Gordon MV, McMahon LP, Hamblin PS. Life-threatening milkalkali syndrome resulting from antacid ingestion during pregnancy. Med J Aust 182: 350-351, 2005.
7. Beall DP, Henslee HB, Webb HR, Scofield RH. Milk-alkali syndrome: a historical review and description of the modern version of the syndrome. Am J Med Sci 331: 233-242, 2006.
8. George S, Clark JD. Milk alkali syndrome-an unusual syndrome causing an unusual complication. Postgrad Med J 76: 422-423, 2000.
9. Picolos MK, Lavis VR, Orlander PR. Milk-alkali syndrome is a major cause of hypercalcaemia among non-end-stage renal disease (non-ESRD) inpatients. Clin Endocrinol (Oxf) 63: 566-576, 2005.
10. Kaklamanos M, Perros P. Milk alkali syndrome without the milk. BMJ 335: 397-398, 2007.
11. Kleinig TJ, Torpy DJ. Milk-alkali syndrome: broadening the spectrum of cause to allow early recognition. Intern Med J 34: 366-367, 2004.
12. Hanada S, Iwamoto M, Kobayashi N, Ando R, Sasaki S. Calciumalkali syndrome due to vitamin D administration and magnesium oxide administration. Am J Kidney Dis 53: 711-714, 2009.
13. Sulkin T, Krentz AJ. Iatrogenic recurrent severe hypercalcaemia and renal impairment. Postgrad Med J 76: 800-807, 2000.
14. Kotchen TA, Guthrie GP Jr. Effect of calcium on renin and aldosterone. Am J Cardiol 62: 41G-46G, 1988.
15. Porsti IH. Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney. Kidney Int 74: 1371-1373, 2008.
16. Greger R. New insights into the molecular mechanism of the action of diuretics. Nephrol Dial Transplant 14: 536-540, 1999.
17. Sebastian A. Thiazides and bone. Am J Med 109: 429-430, 2000.
18. 2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest 115: 1651-1658, 2005.
19. 2+ handling in a mouse model for Gitelman's syndrome. J Am Soc Nephrol 15: 2276-2288, 2004.
20. Paillard M, Bichara M. Peptide hormone effects on urinary acidification and acid-bace balance: PTH, ADH, and glucagon. Am J Physiol 256: F973-F985, 1989.
21. Girardi AC, Titan SM, Malnic G, Reboucas NA. Chronic effect of parathyroid hormone on NHE3 expression in rat renal proximal tubules. Kidney Int 58: 1621-1631, 2000.
22. Sutton RA, Wong NL, Dirks JH. Effects of metabolic acidosis and alkalosis on sodium and calcium transport in the dog kidney. Kidney Int 15: 520-533, 1979.
23. 2+ absorption independent of systemic acid-base changes. Am J Physiol 238: F394-F398, 1980.
24. Punsar S, Somer T. The milk-alkali syndrome. A report of three illustrative cases and a review of the literature. Acta Med Scand 173: 435-449, 1963.