Polygenic inheritance of adolescent idiopathic scoliosis: A study of extended families in Utah

American Journal of Medical Genetics, Part A

Volumn 152, Issue 5, 2010, Pages 1178-1188

  Ward, Kenneth ^a   Ogilvie, James ^a   Argyle, Veeann ^a   Nelson, Lesa ^a   Meade, Mary ^a   Braun, John ^b   Chettier, Rakesh ^a  

^a Axial Biotech Inc   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Adolescent; Genetics; Heritability; Polygenic inheritance; Scoliosis

Indexed keywords

ADOLESCENT; ALLELE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; DISEASE SEVERITY; DISEASE TRANSMISSION; EXTENDED FAMILY; FEMALE; HUMAN; IDIOPATHIC SCOLIOSIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MULTIFACTORIAL INHERITANCE; PEDIGREE ANALYSIS; PENETRANCE; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; RADIODIAGNOSIS; RECURRENCE RISK; RISK FACTOR; SEGREGATION ANALYSIS; SPINE DISEASE; TWIN CONCORDANCE; UNITED STATES;

ADOLESCENT; CHROMOSOME SEGREGATION; FAMILY; FEMALE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MODELS, GENETIC; MULTIFACTORIAL INHERITANCE; PEDIGREE; PHENOTYPE; SCOLIOSIS; SIBLINGS; TWIN STUDIES AS TOPIC; UTAH;

EID: 77951754714     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.33145     Document Type: Article

References (37)

1. Akaike H. 1974. A new look at the statistical model identification. IEEE Trans Automatic Control 19:716-723.
2. Aksenovich TI, Semenov IR, Ginzburg E, Zaidman AM. 1988. Preliminary analysis of inheritance of scoliosis. Genetika 24:2056-2063.
3. Andersen MO, Thomsen K, Kyvik KO. 2007. Adolescent idiopathic scoliosis in twins: A population-based survey. Spine 32:927-930. (Pubitemid 46624315)
4. Axenovich TI, Zaidman AM, Zorkoltseva IV, Tregubova IL, Borodin PM. 1999. Segregation analysis of idiopathic scoliosis: Demonstration of a major gene effect. Am J Med Genet 86:389-394.
5. Carr AJ. 1990. Adolescent idiopathic scoliosis in identical twins. J Bone Joint Surg Br 72:1077. (Pubitemid 20362654)
6. Carter CO. 1969a. Genetics of common disorders. Br Med Bull 25:52-5257.
7. Carter CO. 1969b. Polygenic inheritance and common diseases. Lancet 1:1252-1256.
8. Carter CO. 1977. Principles of polygenic inheritance. Birth Defects Orig Artic Ser 13:69-74.
9. Cheng JC, Tang NL, Yeung HY, Miller N. 2007. Genetic association of complex traits: Using idiopathic scoliosis as an example. Clin Orthop Relat Res 462:38-44. (Pubitemid 47367841)
10. Cowell HR, Hall JN, MacEwen GD. 1972. Genetic aspects of idiopathic scoliosis. A Nicholas Andry Award essay,1970. Clin Orthop Relat Res 86:121-131.
11. Czeizel A, Bellyei A, Barta O, Magda T, Molnar L. 1978. Genetics of adolescent idiopathic scoliosis. J Med Genet 15:424-427.
12. Demenais FM, Bonney GE. 1989. Equivalence of the mixed and regressive models for genetic analysis. I. Continuous traits. Genet Epidemiol 6:597-617.
13. Fitzsimons RB, Tyer HD. 1980. A study of a myopathy presenting as idiopathic scoliosis. Multicore disease or mitochondrial myopathy? J Neurol Sci 46:33-48.
14. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, WuY Z, Plass C, Esteller M. 2005. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 102:10604-10609. (Pubitemid 41061601)
15. Fraser FC. 1976. The multifactorial/threshold concept - Uses and misuses. Teratology 14:267-280.
16. Fraser FC. 1981. Genetics society of Canada award of excellence lecture. The genetics of common familial disorders - Major genes or multifactorial? Can J Genet Cytol 23:1-8.
17. Harrington PR. 1977. The etiology of idiopathic scoliosis. Clin Orthop Relat Res 126:17-25.
18. Inoue M, Minami S, Kitahara H, Otsuka Y, Nakata Y, Takaso M, Moriya H. 1998. Idiopathic scoliosis in twins studied by DNA fingerprinting: The incidence and type of scoliosis. J Bone Joint Surg Br 80:212-217. (Pubitemid 128472080)
19. Justice CM, Miller NH, Marosy B, Zhang J, Wilson AF. 2003. Familial idiopathic scoliosis: Evidence of an X-linked susceptibility locus. Spine 28:589-594. (Pubitemid 36343749)
20. Kesling KL, Reinker KA. 1997. Scoliosis in twins. A meta-analysis of the literature and report of six cases. Spine 22:2009-2014; discussion 2015.
21. Kostuik JP. 1990. Operative treatment of idiopathic scoliosis. J Bone Joint Surg Am 72:1108-1113.
22. Lenke L. 2007. The Lenke Classification System for Scoliosis. St. Louis: Washington University.
23. Machin GA. 1996.Some causes of genotypic and phenotypic discordance in monozygotic twin pairs. Am J Med Genet 61:216-228. (Pubitemid 26036266)
24. Miller NH. 2007. Genetics of familial idiopathic scoliosis. Clin Orthop Relat Res 462:6-10.
25. Miller NH, Schwab DL, Sponseller PD, Manolio TA, Pugh EW, Wilson AP. 2001. Characterization of idiopathic scoliosis in a clinically well-defined population. Clin Orthop Relat Res 392:349-357.
26. Miller NH, Justice CM, Marosy B, Doheny KF, Pugh E, Zhang J, Dietz HC III, Wilson AF. 2005. Identification of candidate regions for familial idiopathic scoliosis. Spine 30:1181-1187. (Pubitemid 40695929)
27. Ogilvie JW, Braun J, Argyle V, Nelson L, Meade M, Ward K. 2006. The search for idiopathic scoliosis genes. Spine 31:679-681.
28. Petronis A. 2006. Epigenetics and twins: Three variations on the theme. Trends Genet 22:347-350. (Pubitemid 44015966)
29. Riseborough EJ, Wynne-Davies R. 1973. A genetic survey of idiopathic scoliosis in Boston, Massachusetts. J Bone Joint Surg Am 55:974-982.
30. Robin GC, Cohen T. 1975. Familial scoliosis. A clinical report. J Bone Joint Surg Br 57:146-148.
31. Shindle MK, Khanna AJ, Bhatnagar R, Sponseller PD. 2006. Adolescent idiopathic scoliosis: Modern management guidelines. J Surg Orthop Adv 15:43-52.
32. U.S. Census Bureau. 2006. 2006 American Community Survey Data Profile Highlights. Washington, D.C.: U.S. Census Bureau, 2006 American Community Survey.
33. van Rhijn LW, Jansen EJ, Plasmans CM, Veraart BE. 2001a. Changing curve pattern in infantile idiopathic scoliosis: Family report with a follow-up of 15 years. Spine 26:E373-E376.
34. van Rhijn LW, Jansen EJ, Plasmans CM, Veraart BE. 2001b. Curve characteristics in monozygotic twins with adolescent idiopathic scoliosis: 3 new twin pairs and a review of the literature. Acta Orthop Scand 72:621-625.
35. Weinstein SL, Dolan LA, Cheng JC, Danielsson A, Morcuende JA. 2008. Adolescent idiopathic scoliosis. Lancet 371:1527-1537.
36. Weiss HR. 2007. Idiopathic scoliosis: How much of a genetic disorder? Report of five pairs of monozygotic twins. Dev Neurorehabil 10: 67-73.
37. Wynne-Davies R. 1968. Familial (idiopathic) scoliosis. A family survey. J Bone Joint Surg Br 50:24-30.