CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19

European Journal of Immunology

Volumn 40, Issue 5, 2010, Pages 1266-1271

  Britschgi, Mirjam R ^a   Favre, Stéphanie ^a   Luther, Sanjiv A ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

CCL19; CCL21; CCR7; DC migration

Indexed keywords

MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE;

ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CELL MATURATION; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN SENSITIZATION; T LYMPHOCYTE ACTIVATION;

ALLELES; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL MOVEMENT; CHEMOKINE CCL19; CHEMOKINE CCL21; DENDRITIC CELLS; GENE DOSAGE; GENE EXPRESSION REGULATION; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; RECEPTORS, CCR7; SKIN; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTES;

EID: 77951753963     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939921     Document Type: Article

References (24)

1. Shortman, K. and Naik, S. H., Steady-state and inflammatory dendritic-cell development. Nat. Rev. Immunol. 2007. 7: 19-30.
2. Forster, R., Davalos-Misslitz, A. C. and Rot, A., CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 2008. 8: 362-371.
3. Randolph, G. J., Angeli, V. and Swartz, M. A., Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 2005. 5: 617-628.
4. Alvarez, D., Vollmann, E. H. and von Andrian, U. H., Mechanisms and consequences of dendritic cell migration. Immunity 2008. 29: 325-342.
5. Forster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner-Muller, I., Wolf, E. and Lipp, M., CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999. 99: 23-33. (Pubitemid 29468627)
6. Martin-Fontecha, A., Sebastiani, S., Hopken, U. E., Uguccioni, M., Lipp, M., Lanzavecchia, A. and Sallusto, F., Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J. Exp. Med. 2003. 198: 615-621.
7. Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T. et al., CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 2004. 21: 279-288. (Pubitemid 39094056)
8. Nakano, H., Lin, K. L., Yanagita, M., Charbonneau, C., Cook, D. N., Kakiuchi, T. and Gunn, M. D., Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat. Immunol. 2009. 10: 394-402.
9. Sanchez-Sanchez, N., Riol-Blanco, L. and Rodriguez-Fernandez, J. L., The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 2006. 176: 5153-5159.
10. Link, A., Vogt, T. K., Favre, S., Britschgi, M. R., Acha-Orbea, H., Hinz, B., Cyster, J. G. and Luther, S. A., Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naïve T cells. Nat. Immunol. 2007. 8: 1255-1265.
11. Gunn, M. D., Kyuwa, S., Tam, C., Kakiuchi, T., Matsuzawa, A., Williams, L. T. and Nakano, H., Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 1999. 189: 451-460.
12. Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G. and Cyster, J. G., Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 2000. 97: 12694-12699.
13. Saeki, H., Moore, A. M., Brown, M. J. and Hwang, S. T., Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 1999. 162: 2472-2475. (Pubitemid 29309263)
14. Robbiani, D. F., Finch, R. A., Jager, D., Muller, W. A., Sartorelli, A. C. and Randolph, G. J., The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 2000. 103: 757-768.
15. Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D. and Williams, L. T., A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naïve T lymphocytes. Proc. Natl. Acad. Sci. USA 1998. 95: 258-263.
16. Lo, J. C., Chin, R. K., Lee, Y., Kang, H. S., Wang, Y., Weinstock, J. V., Banks, T. et al., Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J. Clin. Invest. 2003. 112: 1495-1505.
17. Marsland, B. J., Battig, P., Bauer, M., Ruedl, C., Lassing, U., Beerli, R. R., Dietmeier, K. et al., CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity 2005. 22: 493-505. (Pubitemid 40545114)
18. Britschgi, M. R., Link, A., Lissandrin, T. K. and Luther, S. A., Dynamic modulation of CCR7 expression and function on naïve T lymphocytes in vivo. J. Immunol. 2008. 181: 7681-7688.
19. Sallusto, F., Palermo, B., Lenig, D., Miettinen, M., Matikainen, S., Julkunen, I., Forster, R. et al., Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur. J. Immunol. 1999. 29: 1617-1625.
20. Mori, S., Nakano, H., Aritomi, K., Wang, C. R., Gunn, M. D. and Kakiuchi, T., Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J. Exp. Med. 2001. 193: 207-218.
21. Junt, T., Scandella, E., Forster, R., Krebs, P., Krautwald, S., Lipp, M., Hengartner, H. and Ludewig, B., Impact of CCR7 on priming and distribution of antiviral effector and memory CTL. J. Immunol. 2004. 173: 6684-6693. (Pubitemid 39541053)
22. Schaefer, B. C., Schaefer, M. L., Kappler, J.W., Marrack, P. and Kedl, R. M., Observation of antigen-dependent CD8+T-cell/dendritic cell interactions in vivo. Cell Immunol. 2001. 214: 110-122. (Pubitemid 34499465)
23. Hogquist, K. A., Jameson, S. C., Heath, W. R., Howard, J. L., Bevan, M. J. and Carbone, F. R., T cell receptor antagonist peptides induce positive selection. Cell 1994. 76: 17-27. (Pubitemid 24035278)
24. Lutz, M. B., Kukutsch, N., Ogilvie, A. L., Rossner, S., Koch, F., Romani, N. and Schuler, G., An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 1999. 223: 77-92. (Pubitemid 29096240)