Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients

Archives of Physiology and Biochemistry

Volumn 116, Issue 2, 2010, Pages 57-62

  Ülgen, Fatma ^a   Herder, Christian ^b   Kühn, Markus C ^a   Willenberg, Holger S ^a   Schott, Matthias ^a   Scherbaum, Werner A ^a   Schinner, Sven ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Insulin resistance RBP4; Obesity

Indexed keywords

GLUCOSE; INSULIN; PLASMA RETINOL BINDING PROTEIN; TRIACYLGLYCEROL;

ADIPOCYTE; ADULT; ARTICLE; BLOOD; BLOOD PRESSURE; BODY MASS; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RESISTANCE; LIVER; MALE; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; OBESITY; PHYSIOLOGY; STATISTICAL MODEL; WAIST HIP RATIO;

ADIPOCYTES; ADULT; BLOOD PRESSURE; BODY MASS INDEX; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; LINEAR MODELS; LIVER; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; RETINOL-BINDING PROTEINS, PLASMA; TRIGLYCERIDES; WAIST-HIP RATIO;

ANIMALIA;

EID: 77951748634     PISSN: 13813455     EISSN: 17444160     Source Type: Journal    
DOI: 10.3109/13813451003631421     Document Type: Article

References (29)

1. Aeberli I, Biebinger R, Lehmann R, l'Allemand D, Spinas GA, Aeberli I, Biebinger R, Lehmann R, L'allemand D, Spinas GA.
2. Zimmermann MB. (2007). Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J.Clin.Endocrinol.Metab, 92: 4359-4365
3. Bjorntorp P. (1991). Metabolic implications of body fat distribution. Diabetes Care, 14: 1132-1143
4. Broch M, Vendrell J, Ricart W, Richart C, Fernandez-real JM. (2007). Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects. Diabetes Care, 30: 1802-1806 (Pubitemid 47036355)
5. Casabiell X, Pineiro V, Vega F, De la cruz LF, Dieguez C, Casanueva FF. (2001). Leptin, reproduction and sex steroids. Pituitary., 4: 93-99
6. Cheung BM. (2008). Hypertension as part of the metabolic syndrome. J.Hum.Hypertens. 22:871-874
7. Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH, Lee HK, Park KS. (2006). Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care, 29: 2457-2461
8. Defronzo RA, Ferrannini E. (1991). Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care, 14: 173-194
9. Eynatten M, Lepper PM, Liu D, Lang K, Baumann M, Nawroth PP, Bierhaus A, Dugi KA, Heemann U, Allolio B, Humpert PM. (2007). Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease. Diabetologia, 50: 1930-1937
10. Gomez-ambrosi J, Rodriguez A, Catalan V, Ramirez B, Silva C, Rotellar F, Gil MJ, Salvador J, Fruhbeck G. (2008). Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus, but is reduced after relevant reductions in body fat following gastric bypass. Clin. Endocrinol.(Oxf), 69: 208-215
11. Graham TE, Wason CJ, Bluher M, Kahn BB. (2007). Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia, 50: 814-823
12. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A., Jansson PA, Smith U, Kahn BB. (2006). Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N.Engl.J.Med., 354: 2552-2563
13. Ingelsson E, Sundstrom J, Melhus H, Michaelsson K, Berne C, Vasan RS, Riserus U, Blomhoff R, Lind L, Arnlov J. (2009). Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly. Atherosclerosis, 206: 239-244
14. Jia W, Wu H, Bao Y, Wang C, Lu J, Zhu J, Xiang K. (2007). Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. J.Clin. Endocrinol.Metab, 92: 3224-3229
15. Kloting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schon MR, Stumvoll M, Bluher M, Kahn BB. (2007). Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab, 6: 79-87.
16. Kowalska I, Straczkowski M, Adamska A, Nikolajuk A, Karczewskakupczewska M, Otziomek E, Gorska M. (2008). Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance. J.Clin.Endocrinol.Metab, 93: 2786-2789
17. Lee DC, Lee JW, Im JA. (2007). Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Metabolism, 56: 327-331
18. Lewis JG, Shand BI, Frampton CM, Elder PA, Scott RS. (2008). Plasma retinol-binding protein is not a marker of insulin resistance in overweight subjects: a three year longitudinal study. Clin.Biochem., 41: 1034-1038
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. (1985). Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28: 412-419
20. Mody N, Graham TE, Tsuji Y, Yang Q, Kahn BB. (2008). Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice. Am.J.Physiol Endocrinol.Metab, 294: E785-E793.
21. Mohlig M, Weickert MO, Ghadamgahi E, Arafat AM, Spranger J, Pfeiffer AF, Schofl C. (2008). Retinol-binding protein 4 is associated with insulin resistance, but appears unsuited for metabolic screening in women with polycystic ovary syndrome. Eur.J.Endocrinol., 158: 517-523
22. Muoio DM, Newgard CB. (2005). Metabolism: A is for adipokine. Nature, 436: 337-338
23. Rasouli N, Kern PA. (2008). Adipocytokines and the metabolic complications of obesity. J.Clin.Endocrinol.Metab, 93: S64-73.
24. Takebayashi K, Suetsugu M, Wakabayashi S, Aso Y, Inukai T. (2007). Retinol binding protein-4 levels and clinical features of type 2 diabetes patients. J.Clin.Endocrinol.Metab, 92: 2712-2719
25. Tamori Y, Sakaue H, Kasuga M. (2006). RBP4, an unexpected adipokine. Nat.Med., 12: 30-31
26. Tan BK, Chen J, Lehnert H, Kennedy R, Randeva HS. (2007). Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: effects of gonadal and adrenal steroids. J.Clin.Endocrinol. Metab, 92: 2764-2772
27. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, Heinze E, Teller W, Hauner H. (1997). Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J.Clin.Invest, 100: 808-813
28. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. (2005). Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature, 436: 356-362
29. Yao-borengasser A, Varma V, Bodles AM, Rasouli N, Phanavanh B, Lee MJ, Starks T, kern LM, Spencer HJ, III, Rashidi AA, Mcgehee RE, Jr., Fried SK, Kern PA. (2007). Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J. Clin.Endocrinol.Metab, 92: 2590-2597