The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats

Pakistan Journal of Pharmaceutical Sciences

Volumn 23, Issue 2, 2010, Pages 170-174

  Sepehri, Gholamreza ^a   Sheibani, Vahid ^a   Azarang, Afrooz ^a   Shamsizadeh, Ali ^b   Afarinesh, Mohammad Reza ^a   Azizollahi, Saeed ^c   Sepehri, Ehsan ^d  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Calmodulin inhibitor (W 7); Morphine tolerance; Rat

Indexed keywords

CALMODULIN; MORPHINE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; ATTENUATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG INHIBITION; HEAT TOLERANCE; MALE; MORPHINE TOLERANCE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; RAT; TAIL FLICK TEST; THERMAL STIMULATION; WISTAR RAT;

ANALGESICS, OPIOID; ANIMALS; CALMODULIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG TOLERANCE; ENZYME INHIBITORS; INJECTIONS, INTRAVENTRICULAR; MALE; MORPHINE; PAIN THRESHOLD; RATS; RATS, WISTAR; SULFONAMIDES;

EID: 77951733611     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Breivogel CS, Selley DE and Childers SR (1997). Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes. J. Neurochem, 68: 1462-1472.
2. Cheung WY (1982). Calmodulin: an overview. Fed. Proc., 41: 2253-2257.
3. Deisseroth K, Heist EK and Tsien RW (1998). Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature, 392: 198-202. (Pubitemid 28162795)
4. Diaz A, Ruiz F, Florez J, Pazos A and Hurle MA (1995). Regulation of dihydropyridine-sensitive Ca++ channels during opioid tolerance and supersensitivity in rats. J. Pharmacol. Exp. Ther., 274: 1538-1544.
5. Dinsmore JH and Sloboda RD (1988). Calcium and calmodulin-dependent phosphorylation of a 62 kd protein induces microtubule depolymerization in sea urchin mitotic apparatuses. Cell, 53: 769-780.
6. Doi T, Kuzuna S and Fujino M (1988). Study on the receptor subtypes mediating the analgesic action of an enkephalin analog, Tyr-D-Met(O)-Gly-EtPhe- NHNHCOCH3.AcOH (EK-399). Jpn. J. Pharmacol., 47: 409-415.
7. Eisch AJ, Barrot M, Schad CA, Self DW and Nestler EJ (2000). Opiates inhibit neurogenesis in the adult rat hippocampus. Proc. Natl. Acad. Sci. USA, 97: 7579-7584. (Pubitemid 30431506)
8. Esmaeili-Mahani S, Motamedi F, Javan M and Ahmadiani A (2005). Involvement of hypothalamic pituitary adrenal axis on the effects of nifedipine in the development of morphine tolerance in rats. Pharmacol. Biochem. Behav., 81: 152-157. (Pubitemid 40718963)
9. Gnegy ME (1993). Calmodulin in neurotransmitter and hormone action. Annu. Rev. Pharmacol. Toxicol., 33: 45-70.
10. Hamdy MM, Noda Y, Miyazaki M, Mamiya T, Nozaki A, Nitta A, Sayed M, Assi AA, Gomaa A and Nabeshima T (2004). Molecular mechanisms in dizocilpine-induced attenuation of development of morphine dependence: An association with cortical Ca2+/calmodulin-dependent signal cascade. Behav. Brain Res., 152: 263-270. (Pubitemid 38757897)
11. Kelley AE, Bakshi VP, Fleming S and Holahan MR (2000). A pharmacological analysis of the substrates underlying conditioned feeding induced by repeated opioid stimulation of the nucleus accumbens. Neuropsychopharmacology, 23: 455-467.
12. Koch T, Kroslak T, Mayer P, Raulf E and Hollt V (1997). Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin- dependent protein kinase II in agonist-mediated desensitization. J. Neurochem., 69: 1767-1770. (Pubitemid 27406979)
13. Liang D, Li X and Clark JD (2004). Increased expression of Ca2+/calmodulin-dependent protein kinase II alpha during chronic morphine exposure. Neuroscience, 123: 769-775. (Pubitemid 38045414)
14. Lou L, Zhou T, Wang P & Pei G (1999). Modulation of Ca2+/calmodulin-dependent protein kinase II activity by acute and chronic morphine administration in rat hippocampus: differential regulation of alpha and beta isoforms. Mol. Pharmacol., 55: 557-563. (Pubitemid 29128114)
15. Mestek A, Hurley JH, Bye LS, Campbell AD, Chen Y, Tian M, Liu J, Schulman H and Yu L (1995). The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C. J. Neurosci., 15: 2396-2406.
16. Nehmad R, Nadler H and Simantov R (1982). Effects of acute and chronic morphine treatment of calmodulin activity of rat brain. Mol. Pharmacol., 22: 389-394. (Pubitemid 12028837)
17. Nestler EJ and Aghajanian GK (1997). Molecular and cellular basis of addiction. Science, 278: 58-63.
18. Niu S, Kuo CH, Gan Y, Nishikawa E, Sadakata T, Ichikawa H and Miki N (2000). Increase of calmodulin III gene expression by mu-opioid receptor stimulation in PC12 cells. Jpn. J. Pharmacol., 84: 412-417. (Pubitemid 32043733)
19. Paxinos GWC (1986). The rat brain in stereotaxic coordinates.Second Edition, Academic Press, Sydney, figure 22, pp44.
20. Tang L, Shukla PK, Wang LX and Wang ZJ (2006). Reversal of morphine antinociceptive tolerance and dependence by the acute supraspinal inhibition of Ca(2+)/calmodulin-dependent protein kinase II. J. Pharmacol. Exp. Ther., 317: 901-909.
21. Wang D, Sadee W and Quillan JM (1999). Calmodulin binding to G protein-coupling domain of opioid receptors. J. Biol. Chem., 274: 22081-22088. (Pubitemid 129519768)
22. Wang D, Tolbert LM, Carlson KW and Sadee W (2000). Nuclear Ca2+/calmodulin translocation activated by mu-opioid (OP3) receptor. J. Neurochem., 74: 1418-1425.
23. Welch SP and Olson KG (1991). Opiate toleranceinduced modulation of free intracellular calcium in synaptosomes. Life Sci., 48: 1853-1861.
24. Wroblewski JT and Danysz W (1989). Modulation of glutamate receptors: molecular mechanisms and functional implications. Annu. Rev. Pharmacol. Toxicol., 29: 441-474.
25. Yabaluri N an Medzihradsky F (1997). Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling. Mol. Pharmacol., 52: 896-902.
26. Ye XF, Lu Y, Zhang P and Liang JH (2004). Calmodulin inhibitor trifluoperazine attenuates the development and expression of morphine-induced conditioned place preference in rats. Eur. J. Pharmacol., 486: 265-271. (Pubitemid 38231056)