Immunohistochemistry in non-immune hydrops fetalis: A single center experience in 79 fetuses

American Journal of Medical Genetics, Part A

Volumn 152, Issue 5, 2010, Pages 1189-1196

  Bellini, Carlo ^a   Fulcheri, Ezio ^b   Rutigliani, Mariangela ^b   Calevo, Maria Grazia ^c   Boccardo, Francesco ^b   Campisi, Corradino ^b   Bonioli, Eugenio ^a   Bellini, Tommaso ^a   Hennekam, Raoul C M ^d,e  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c G GASLINI INSTITUTE   (Italy)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Autopsy; Human fetus; Immunohistochemistry; Non immune hydrops fetalis

Indexed keywords

ACTIN ANTIBODY; CD 31 ANTIBODY; CD34 ANTIBODY; CELL ANTIBODY; MONOCLONAL ANTIBODY D2-40; UNCLASSIFIED DRUG;

ARTICLE; AUTOPSY; BLOOD VESSEL; FETUS; FETUS HYDROPS; HUMAN; HUMAN EXPERIMENT; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL; LYMPHATIC SYSTEM DISEASE; LYMPHATIC TISSUE DYSPLASIA; NON IMMUNE FETUS HYDROPS; PRIORITY JOURNAL;

ANTIGENS, CD31; ANTIGENS, CD34; AUTOPSY; FEMALE; FETUS; HUMANS; HYDROPS FETALIS; IMMUNOHISTOCHEMISTRY; PLACENTA; PREGNANCY;

EID: 77951728559     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.33191     Document Type: Article

References (40)

1. Alitalo K, Tammela T, Petrova TV. 2005. Lymphangiogenesis in development and human disease. Nature 438:946-953.
2. Aspillaga C, Las Heras J, Kakarieka E. 1994. Nonimmunological hydrops fetalis. Experience with 33 cases. Rev Chil Obstet Ginecol 59:448-456.
3. Bailey D, Baumal R, Law J, Sheldon K, Kannampuzha P, Stratis M. 1986. Production of a monoclonal antibody specific for seminomas and dysgerminomas. Proc Natl Acad Sci USA 83:5291-5295. (Pubitemid 16051361)
4. Bailey D, Marks A, Stratis M, Baumal R. 1991. Immunohistochemical staining of germ cell tumors and intratubular malignant germ cells of the testis using antibody to placental alkaline phosphatase and a monoclonal anti-seminoma antibody. Mod Pathol 4:167-171.
5. Bellini C, Hennekam RC, Boccardo F, Campisi C, Serra G, Bonioli E. 2006a. Nonimmune idiopathic hydrops fetalis and congenital lymphatic dysplasia. Am J Med Genet Part A 140A:678-684.
6. Bellini C, Boccardo F, Bonioli E, Campisi C. 2006b. Lymphodynamics in the fetus and newborn. Lymphology 39:110-117.
7. Bellini C, Hennekam RCM, Fulcheri E, Rutigliani M, Morcaldi G, Boccardo F, Bonioli E. 2009a. Etiology of nonimmune hydrops fetalis: A systematic review. Am J Med Genet Part A 149A:844-851.
8. Bellini C, Hennekam RCM, Bonioli E. 2009b. A diagnostic flow chart for non-immune hydrops fetalis. Am J Med Genet Part A 149A:852-853.
9. Brace RA. 2004. Fluid distribution in the fetus and neonate. In: Polin RA, Fox WW, Abam SH, editors. Fetal and neonatal physiology. 2nd edition. Philadelphia: Saunders. pp 1341-1364.
10. Branch DW. 1987. Immunologic disease and fetal death. Clin Obstet Gynecol 30:295-311.
11. Brown M, Pysher T, Coffin CM. 1999. Lymphangioma and congenital pulmonary lymphangiectasis: A histologic, immunohistochemical, and clinicopathologic comparison. Mod Pathol 12:569-575. (Pubitemid 29279708)
12. Bukowski R, Saade GR. 2000. Hydrops fetalis. Clin Perinatol 27:1007-1031.
13. Choi WW, Lewis MM, Lawson D, Yin-Goen Q, Birdsong GG, Cotsonis GA. 2005. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: Correlation with clinicopathologic parameters and VEGF-family gene expression. Mod Pathol 18:143-152. (Pubitemid 40128107)
14. Dabbs DJ. 2006. Diagnostic immunohistochemistry. 2nd edition. London: Churchill Livingstone.
15. Debelenko LV, Perez-Atayde AR, Mulliken JB, Liang MG, Archibald TH, Kozakewich HP. 2005. D2-40 immunohistochemical analysis of pediatric vascular tumors reveals positivity in kaposiform hemangioendothelioma. Mod Pathol 18:1454-1460.
16. Dumoff KL, Chu C, Xu X, Pasha T, Zhang PJ, Acs G. 2005. Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol 18:97-104. (Pubitemid 40128101)
17. Elias JM, Gown AM, Nakamura RM. 1989. Quality control in immunohistochemistry. Report of a workshop sponsored by the Biological Stain Commission. Am J Clin Pathol 92:836-843.
18. Franchi A, Gallo O, Massi D, Baroni G, Santucci M. 2004. Tumor lymphangiogenesis in head and neck squamous cell carcinoma: A morphometric study with clinical correlations. Cancer 101:973-978. (Pubitemid 39100431)
19. Gomaa AH, Yaar M, Bhawan J. 2007. Cutaneous immunoreactivity of D2-40 antibody beyond the lymphatics. Am J Dermatopathol 29:18-21. (Pubitemid 46220234)
20. Heinonen S, Ryynanen M, Kirkinen P. 2000. Etiology and outcome of second trimester non-immunologic fetal hydrops. Acta Obstet Gynecol Scand 79:15-18. (Pubitemid 30045285)
21. Hsu SM, Raine L, Fanger H. 1981.Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29: 577-580. (Pubitemid 11147380)
22. Ji RC. 2008. Lymphatic endothelial cells, lymphedematous lymphangiogenesis, and molecular control of edema formation. Lymphat Res Biol 6:123-137.
23. Kahn HJ, Marks A. 2002. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest 82: 1255-1257. (Pubitemid 35014860)
24. Karpanen T, Alitalo K. 2008. Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol 3:367-397.
25. Kiefer F, Adams RH. 2008. Lymphatic endothelial differentiation: Start out with Sox-carry on with Prox. Genome Biol 9:243.
26. Knisely AS. 1995. The pathologist and the hydropic placenta, fetus, or infant. Semin Perinatol 19:525-531.
27. Landis JR, Koch GG. 1977. The measurement of observer agreement for categorical data. Biometrics 33:159-174.
28. Lockwood CJ, Nadel AS, King ME, Roberts DJ. 2009. Case records of the Massachusetts General Hospital. Case 16-2009. A 32-year-old pregnant woman with an abnormal fetal ultrasound study. N Engl J Med 360:2225-2235.
29. Mahony BS, Filly RA, Callen PW, Chinn DH, Golbus MS. 1944. Severe nonimmune hydrops fetalis: Sonographic evaluation. Radiology 151: 757-761.
30. Mäkinen T, Norrmén C, Petrova TV. 2007. Molecular mechanisms of lymphatic vascular development. Cell Mol Life Sci 64:1915-1929. (Pubitemid 47094431)
31. Marks A, Sutherland DR, Bailey D, Iglesias J, Law J, Lei M. 1999. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours. Br J Cancer 80:569-578. (Pubitemid 29213215)
32. Mascaretti RS, Falcao MC, Silva AM, Vaz FA, Leone CR. 2003. Characterization of newborns with nonimmune hydrops fetalis admitted to a neonatal intensive care unit. Rev Hosp Clin Fac Med Sao Paulo 58: 125-132.
33. Ochiai M, Hikino S, Nakayama H, Ohga S, Taguchi T, Hara T. 2006. Nonimmune hydrops fetalis due to generalized lymphatic dysplasia in an infant with Robertsonian trisomy 21. Am J Perinatol 23:63-66. (Pubitemid 43214407)
34. Ordonez NG. 2006. Podoplanin:A novel diagnostic immunohistochemical marker. Adv Anat Pathol 13:83-88.
35. Rutigliani M, Boccardo F, Campisi C, Bonioli E, Fulcheri E, Bellini C. 2007. Immunohistochemical studies in a hydroptic fetus with pulmonary lymphangiectasia and trisomy 21. Lymphology 40:114-121. (Pubitemid 350060118)
36. Sauter B, Foedinger D, Sterniczki B, Wolff K, Rappersberger K. 1998. Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells. Differential expression of CD31, CD34 and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ. J Histochem Cytochem 46:165-176. (Pubitemid 28087847)
37. Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK, Detmar M. 2005. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 166:913-921. (Pubitemid 40315647)
38. Swain S, Cameron AD, McNay MB, Howatson AG. 1999. Prenatal diagnosis and management of nonimmune hydrops fetalis. Aust N Z J Obstet Gynecol 39:285-290. (Pubitemid 29431484)
39. Tammela T, Petrova TV, Alitalo K. 2005. Molecular lymphangiogenesis: New players. Trends Cell Biol 15:434-441.
40. Yamashita JK. 2007. Differentiation of arterial, venous, and lymphatic endothelial cells from vascular progenitors. Trends Cardiovasc Med 17:59-63. (Pubitemid 46205329)