Determination of bencycloquidium bromide in dog plasma by liquid chromatography with electrospray ionization tandem mass spectrometry

Biomedical Chromatography

Volumn 24, Issue 5, 2010, Pages 490-496

  Jiang, Bo ^a   Ruan, Zourong ^a   Lou, Honggang ^a   Dong, Xinwei ^b   Xie, Qiangmin ^b  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Beagle dogs; Bencyloquidium bromide; LC MS MS

Indexed keywords

ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POSITIVE IONS;

BEAGLE DOG; BENCYLOQUIDIUM BROMIDE; DOG PLASMA; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; INTERNAL STANDARDS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; PLASMA SAMPLES; SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY;

METHANOL;

ACETIC ACID; AMMONIUM ACETATE; BENCYCLOQUIDIUM BROMIDE; BROMINE DERIVATIVE; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; LEVO ETHYL BENCYCLOQUIDIUM BROMIDE; METHANOL; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOG; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; LIQUID CHROMATOGRAPHY; STANDARD; SUPERNATANT;

CANIS FAMILIARIS;

EID: 77951728529     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1316     Document Type: Article

References (8)

1. Guidance for Industry: Statistical Approaches to Establishing Bioequivalence. USDHHS, FDA, CDER, CVM. 2001.
2. Li TW, Zhao ShQ, Zhang JQ, Chen K and Zhang Q. China Patent CN 1532196A (29 Septemper 2004).
3. Li Y and Zhou YD. Experimental study on general pharmacological actions of bencycloquidium bromide. Journal of Chongqing Medical University 2007; 32: 506-510.
4. Li Y, Zhou YD and Chen XP. Preliminary observation on the antiinfl ammatory action and anti-pruritic action of bencycloquidium bromide. Chinese Journal of New Drugs 2007; 16: 1182-1184.
5. Xu Q, Ding L, Liu WY, Bian X and Tang W. Determination of bencycloquidium bromide in rat plasma by liquid chromatography-electrospray ionization-mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Science 2007; 846: 209-214. (Pubitemid 46149515)
6. Xu Q, Ding L, Liu WY, Chen XP and Liu BM. Study of the metabolites of bencycloquidium bromide racemate, a novel anticholinergic compound, in rat bile by liquid chromatography-tandem mass spectrometry. European Journal of Mass Spectrometry 2008a; 14: 99-105.
7. Xu Q, Ding L, Liu WY, Li RS, Song QX and Chen XP. Determination of bencycloquidium bromide, a novel anticholinergic compound, in rat tissues by liquid chromatography-electrospray ionization mass spectrometry. European Journal of Mass Spectrometry 2008b; 14: 319-327.
8. Zhou WJ, Ding L, Wang YQ, Sun LN, Huang Y, Hu LL and Chen XP. Solid phase extraction and liquid chromatography-electrospray ionization-massspectrometry for the determination of bencycloquidium bromide in human plasma. Journal of Chromatography B 2009; 877: 897-901.