5D-intravital tomography as a novel tool for non-invasive in-vivo analysis of human skin

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7555, Issue , 2010, Pages

  König, Karsten ^a,b   Weinigel, Martin ^a   Breunig, Hans G ^a   Gregory, Axel ^a   Fischer, Peter ^a   Kellner Höfer, Marcel ^a   Bückle, Rainer ^a   Schwarz, Martin ^c   Riemann, Iris ^c   Stracke, Frank ^c   Huck, Volker ^d   Gorzelanny, Christian ^d   Schneider, Stefan W ^d,e  

^a JENLAB GMBH   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c FRAUNHOFER INSTITUTE FOR BIOMEDICAL ENGINEERING   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Clinical imaging; Dermatitis; FLIM; Multiphoton tomography; Non linear microscopy; Skin; Spectral imaging; Two photon

Indexed keywords

CLINICAL IMAGING; MULTIPHOTON TOMOGRAPHY; NONLINEAR MICROSCOPY; SPECTRAL IMAGING; TWO PHOTON;

DERMATITIS; EMISSION SPECTROSCOPY; HARMONIC GENERATION; IMAGING SYSTEMS; MEDICAL IMAGING; NONLINEAR OPTICS; OPTOELECTRONIC DEVICES; PHOTONS; PORPHYRINS; THREE DIMENSIONAL;

TOMOGRAPHY;

EID: 77951720276     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.841861     Document Type: Conference Paper

References (10)

1. König, K., and Riemann, I., "High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution", J Biomed Optics 8, 450-459 (2003).
2. König, K., "Clinical multiphoton tomography", J Biophotonics 1, 13-23 (2008).
3. Dimitrow, E., Ziemer, M., Koehler, M. J., Norgauer, J., König, K., Elsner, P., and Kaatz, M., "Sensitivity and specificity of multiphoton laser tomography for in vivo and ex vivo diagnosis of malignant melanoma", J Invest Dermatol 129, 1752-1758 (2009).
4. Koehler, M. J., König, K., Elsner, P., Bückle, R., and Kaatz, M., "In vivo assessment of human skin aging by multiphoton laser scanning tomography", Opt Lett 31, 2879-2881 (2006). (Pubitemid 44600100)
5. Schenke-Layland, K., Riemann, I., Damour, O., Stock, U. A., and König, K., "Two-photon microscopes and in vivo multiphoton tomographs - powerful diagnostic tools for tissue engineering and drug delivery", Adv Drug Deliv Rev 58, 878-896 (2006). (Pubitemid 44794345)
6. Stracke, F., Weiss, B., Lehr, C. M., König, K., Schaefer, U. F., and Schneider, M., "Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs", J Invest Dermatol 126, 2224-2233 (2006). (Pubitemid 44413169)
7. Williams, R. M., Zipfel, W. R., and Webb, W. W., "Interpreting second-harmonic generation images of collagen I fibrils", Biophys J 88, 1377-1386 (2005).
8. König, K., and Riemann, I., "High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution", J Biomed Opt 8, 432-439 (2003). (Pubitemid 35220479)
9. König, K., Ehlers, A., Stracke, F., and Riemann, I., "In vivo drug screening in human skin using femtosecond laser multiphoton tomography", Skin Pharmacol Physiol 19, 78-88 (2006). (Pubitemid 43725817)
10. Huck, V., Gorzelanny, C., Thomas, K., Luger, T. A., König, K., Schneider, S. W., "Intravital multiphoton tomography as a novel tool for non-invasive in vivo analysis of human skin affected with atopic dermatitis", SPIE Proceedings 7548, in press.