Motorized traffic of a cardiac ion channel: Implication of conventional kinesin in transport of Kv1.5 channels to the plasma membrane

Journal of Physiology

Volumn 588, Issue 6, 2010, Pages 903-904

  Akhavan, Armin ^a  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; ION CHANNEL; KINESIN; KINESIN 1; POTASSIUM CHANNEL KV1.5;

CELL MEMBRANE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HEART MUSCLE CELL; HEAVY CHAIN; LIGHT CHAIN; MOLECULAR MECHANICS; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RIBOSOME; ARTICLE; GOLGI MEMBRANE; HEART DISEASE; HUMAN; INTERNALIZATION; MEMBRANE TRANSPORT; PROTEIN PROTEIN INTERACTION;

BIOLOGICAL TRANSPORT; CELL LINE; CELL MEMBRANE; HUMANS; KINESIN; KV1.5 POTASSIUM CHANNEL; MICROTUBULES; MYOBLASTS, CARDIAC; PROTEIN ISOFORMS;

EID: 77951702729     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2009.186692     Document Type: Note

References (4)

1. Choi WS, Khurana A, Mathur R, Vishwanath V, Steele DF, Fedida D. Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. Circ Res 2005, 97:363-371.
2. Hirokawa N, Noda Y. Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics. Physiol Rev 2008, 88:1089-1118.
3. Rivera J, Chu PJ, Lewis TL, Arnold DB. The role of Kif5b in axonal localization of Kv1 K+ channels. Eur J Neurosci 2007, 25:136-146.
4. Zadeh AD, Cheng Y, Xu H, Wong N, Wang Z, Goonsaekara C, Steele DF, Fedida D. Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel. J Physiol 2009, 587:4565-4574.