Update of comprehensive review of the safety profile of bone morphogenetic protein in spine surgery

Neurosurgery

Volumn 66, Issue 5, 2010, Pages

  Smoljanovic, Tomislav ^a   Bicanic, Goran ^a   Bojanic, Ivan ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM PHOSPHATE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT OSTEOGENIC PROTEIN 1;

BONE TRANSPLANTATION; CLINICAL FEATURE; DISEASE SEVERITY; DRUG SAFETY; FOLLOW UP; LEG PAIN; LETTER; NEUROLOGIC DISEASE; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RECURRENT DISEASE; SPINE STABILIZATION; SPINE SURGERY; TRABECULAR BONE; VERTEBRA BODY;

BONE MORPHOGENETIC PROTEINS; CLINICAL TRIALS AS TOPIC; HUMANS; RECOMBINANT PROTEINS; SPINAL FUSION;

EID: 77951686229     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0B013E3181D8CCCD     Document Type: Letter

References (19)

1. Benglis D, Wang MY, Levi AD. A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery. Neurosurgery. 2008;62:ONS423-431; discussion ONS431.
2. Haid RW Jr, Branch CL Jr, Alexander JT, Burkus JK. Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages. Spine J. 2004;4:527-538; discussion 538-1529
3. Wong DA, Kumar A, Jatana S, Ghiselli G, Wong K. Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2). Spine J. 2008;8:1011-1018, 2008.
4. Perri B, Cooper M, Lauryssen C, Anand N. Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study. Spine J. 2007;7:235-239. (Pubitemid 46268849)
5. Laursen M, Hoy K, Hansen ES, Gelineck J, Christensen FB, Bunger CE. Recombinant bone morphogenetic protein-7 as an intracorporal bone growth stimulator in unstable thoracolumbar burst fractures in humans: preliminary results. Eur Spine J. 1999;8:485-490. (Pubitemid 30080570)
6. Caixeta T, Park P, La Marca F. Early focal demineralization following the use of BMP-2 in transverse lumbar interbody fusion. Presented at Joint Section on Disorders of the Spine and Peripheral Nerves (AANS/CNS), 23nd Annual Meeting, Phoenix, AZ, March 7-10, 2007.
7. Lewandrowski KU, Nanson C, Calderon R. Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: a report of five cases. Spine J. 2007;7:609-614. (Pubitemid 47471438)
8. McClellan JW, Mulconrey DS, Forbes RJ, Fullmer N. Vertebral bone resorption after transforaminal lumbar interbody fusion with bone morphogenetic protein (rhBMP-2). J Spinal Disord Tech. 2006;19:483-486. (Pubitemid 44526745)
9. Pradhan BB, Bae HW, Dawson EG, Patel VV, Delamarter RB. Graft resorption with the use of bone morphogenetic protein: lessons from anterior lumbar interbody fusion using femoral ring allografts and recombinant human bone morphogenetic protein-2. Spine. 2006;31:E277-284.
10. Burkus JK, Sandhu HS, Gornet MF, Longley MC. Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery. J Bone Joint Surg Am. 2005;87:1205-1212.
11. Hansen SM, Sasso RC. Resorptive response of rhBMP2 simulating infection in an anterior lumbar interbody fusion with a femoral ring. J Spinal Disord Tech. 2006;19:130-134.
12. Kuklo TR, Rosner MK, Polly DW Jr. Computerized tomography evaluation of a resorbable implant after transforaminal lumbar interbody fusion. Neurosurg Focus. 2004;16:E10.
13. Vaidya R, Carp J, Sethi A, Bartol S, Craig J, Les CM. Complications of anterior cervical discectomy and fusion using recombinant human bone morphogenetic protein-2. Eur Spine J. 2007;16:1257-1265. (Pubitemid 350104617)
14. Vaidya R, Weir R, Sethi A, Meisterling S, Hakeos W, Wybo CD. Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidence. J Bone Joint Surg Br. 2007;89:342-345. (Pubitemid 46563910)
15. Smoljanovic T, Pecina M. Re: Burkus JK, Transfeldt EE, Kitchel SH, et al. Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine. 2002;27:2396-2408. Spine. 2008;33:224 (letter).
16. Smoljanovic T, Grgurevic L, Jelic M, et al. Regeneration of the skeleton by recombinant human bone morphogenetic proteins. Coll Antropol. 2007;31:923-932.
17. Seeherman H, Wozney JM. Delivery of bone morphogenetic proteins for orthopedic tissue regeneration. Cytokine Growth Factor Rev. 2005;16:329-345. (Pubitemid 40910322)
18. Wutzl A, Brozek W, Lernbass I, et al. Bone morphogenetic proteins 5 and 6 stimulate osteoclast generation. J Biomed Mater Res 2006;77:75-83.
19. Miyaji H, Sugaya T, Kato K, Kawamura N, Tsuji H, Kawanami M. Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application. J Periodontal Res. 2006;41:311-315. (Pubitemid 44392301)