Advances in understanding the pathogenesis of chronic thromboembolic pulmonary hypertension

British Journal of Haematology

Volumn 149, Issue 4, 2010, Pages 478-483

  Lang, Irene ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Angiogenesis; Chronic thromboembolic pulmonary hypertension; Fibrinogen; Stem cells; Thrombosis models; Vascular remodelling

Indexed keywords

BOSENTAN; FIBRINOGEN;

ARTERY DISEASE; BLOOD CLOTTING DISORDER; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; CLINICAL TRIAL; ENDARTERECTOMY; FIBRINOLYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HIGH RISK POPULATION; HUMAN; LUNG ARTERY PRESSURE; LUNG EMBOLISM; MORBIDITY; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY ARTERY OCCLUSION PRESSURE; PULMONARY ARTERY STENOSIS; PULMONARY VASCULAR DISEASE; REVIEW; SHUNT INFECTION; VENOUS THROMBOEMBOLISM;

CHRONIC DISEASE; ENDARTERECTOMY; FIBRINOGEN; FIBRINOLYSIS; HUMANS; HYPERTENSION, PULMONARY; PULMONARY EMBOLISM; VENOUS THROMBOEMBOLISM;

EID: 77951684464     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08142.x     Document Type: Review

References (54)

1. Ali, T., Humphries, J., Burnand, K., Sawyer, B., Bursill, C., Channon, K., Greaves, D., Rollins, B., Charo, I.F. Smith, A. (2006) Monocyte recruitment in venous thrombus resolution. Journal of Vascular Surgery, 43, 601 608. (Pubitemid 43332750)
2. Arbustini, E., Morbini, P., D'Armini, A.M., Repetto, A., Minzioni, G., Piovella, F., Vigano, M. Tavazzi, L. (2002) Plaque composition in plexogenic and thromboembolic pulmonary hypertension: the critical role of thrombotic material in pultaceous core formation. Heart, 88, 177 182. (Pubitemid 34787776)
3. Auger, W.R., Permpikul, P. Moser, K.M. (1995) Lupus anticoagulant, heparin use, and thrombocytopenia in patients with chronic thromboembolic pulmonary hypertension: a preliminary report. American Journal of Medicine, 99, 392 396.
4. Azarian, R., Wartski, M., Collignon, M.A., Parent, F., Herve, P., Sors, H. Simonneau, G. (1997) Lung perfusion scans and hemodynamics in acute and chronic pulmonary embolism. Journal of Nuclear Medicine, 38, 980 983. (Pubitemid 27251998)
5. Becattini, C., Agnelli, G., Pesavento, R., Silingardi, M., Poggio, R., Taliani, M.R. Ageno, W. (2006) Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. Chest, 130, 172 175. (Pubitemid 44116856)
6. Benotti, J.R., Ockene, I.S., Alpert, J.S. Dalen, J.E. (1983) The clinical profile of unresolved pulmonary embolism. Chest, 84, 669 678. (Pubitemid 14205444)
7. Blauwet, L.A., Edwards, W.D., Tazelaar, H.D. McGregor, C.G. (2003) Surgical pathology of pulmonary thromboendarterectomy: a study of 54 cases from 1990 to 2001. Human Pathology, 34, 1290 1298.
8. Bonderman, D., Turecek, P.L., Jakowitsch, J., Weltermann, A., Adlbrecht, C., Schneider, B., Kneussl, M., Rubin, L.J., Kyrle, P.A., Klepetko, W., Maurer, G. Lang, I.M. (2003) High prevalence of elevated clotting factor VIII in chronic thromboembolic pulmonary hypertension. Thrombosis and Haemostasis, 90, 372 376. (Pubitemid 37138760)
9. Bonderman, D., Jakowitsch, J., Adlbrecht, C., Schemper, M., Kyrle, P.A., Schonauer, V., Exner, M., Klepetko, W., Kneussl, M.P., Maurer, G. Lang, I. (2005) Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension. Thrombosis and Haemostasis, 93, 512 516. (Pubitemid 40392541)
10. Bonderman, D., Skoro-Sajer, N., Jakowitsch, J., Adlbrecht, C., Dunkler, D., Taghavi, S., Klepetko, W., Kneussl, M. Lang, I.M. (2007) Predictors of outcome in chronic thromboembolic pulmonary hypertension. Circulation, 115, 2153 2158. (Pubitemid 46659067)
11. Bonderman, D., Wilkens, H., Wakounig, S., Schafers, H.J., Jansa, P., Lindner, J., Simkova, I., Martischnig, A.M., Dudczak, J., Sadushi, R., Skoro-Sajer, N., Klepetko, W. Lang, I.M. (2008a) Risk factors for chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 33, 325 331.
12. Bonderman, D., Jakowitsch, J., Redwan, B., Bergmeister, H., Renner, M.K., Panzenbock, H., Adlbrecht, C., Georgopoulos, A., Klepetko, W., Kneussl, M. Lang, I.M. (2008b) Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 678 684. (Pubitemid 351651329)
13. Bonderman, D., Wilkens, H., Wakounig, S., Schafers, H.J., Jansa, P., Lindner, J., Simkova, I., Martischnig, A.M., Dudczak, J., Sadushi, R., Skoro-Sajer, N., Klepetko, W. Lang, I.M. (2009) Risk factors for chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 33, 325 331.
14. Colli, B.O., Starr, E.M. Martelli, N. (1981) [Surgical treatment of hydrocephalus in children. II. Complications]. Arquivos de Neuro-Psiquiatria, 39, 408 419.
15. Condliffe, R., Kiely, D.G., Gibbs, J.S., Corris, P.A., Peacock, A.J., Jenkins, D.P., Goldsmith, K., Coghlan, J.G. Pepke-Zaba, J. (2008) Prognostic and aetiological factors in chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 33, 332 338. (Pubitemid 351717571)
16. Deng, Z., Morse, J.H., Slager, S.L., Cuervo, N., Moore, K.J., Venetos, G., Kalachikov, S., Cayanis, E., Fischer, S.G., Barst, R.J., Hodge, S.E. Knowles, J.A. (2000) Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. American Journal of Human Genetics, 67, 737 744. (Pubitemid 30659603)
17. Du, L., Sullivan, C.C., Chu, D., Cho, A.J., Kido, M., Wolf, P.L., Yuan, J.X., Deutsch, R., Jamieson, S.W. Thistlethwaite, P.A. (2003) Signaling molecules in nonfamilial pulmonary hypertension. New England Journal of Medicine, 348, 500 509. (Pubitemid 36159885)
18. Firth, A.L., Yau, J., White, A., Chiles, P.G., Marsh, J.J., Morris, T.A. Yuan, J.X. (2009) Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology, 296, L979 L986.
19. Furie, B. Furie, B.C. (2008) Mechanisms of thrombus formation. New England Journal of Medicine, 359, 938 949.
20. Henke, P.K. Wakefield, T. (2009) Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes. Thrombosis Research, 123 (Suppl. 4 S72 S78.
21. Henke, P.K., Varga, A., De, S., Deatrick, C.B., Eliason, J., Arenberg, D.A., Sukheepod, P., Thanaporn, P., Kunkel, S.L., Upchurch, Jr., G.R. Wakefield, T.W. (2004) Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 1130 1137. (Pubitemid 38737842)
22. Henke, P.K., Pearce, C.G., Moaveni, D.M., Moore, A.J., Lynch, E.M., Longo, C., Varma, M., Dewyer, N.A., Deatrick, K.B., Upchurch, Jr., G.R., Wakefield, T.W., Hogaboam, C. Kunkel, S.L. (2006) Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. Journal of Immunology, 177, 3388 3397. (Pubitemid 44277859)
23. Hoeper, M.M., Lee, S.H., Voswinckel, R., Palazzini, M., Jais, X., Marinelli, A., Barst, R.J., Ghofrani, H.A., Jing, Z.C., Opitz, C., Seyfarth, H.J., Halank, M., McLaughlin, V., Oudiz, R.J., Ewert, R., Wilkens, H., Kluge, S., Bremer, H.C., Baroke, E. Rubin, L.J. (2006) Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers. Journal of the American College of Cardiology, 48, 2546 2552. (Pubitemid 44881214)
24. Jais, X., Ioos, V., Jardim, C., Sitbon, O., Parent, F., Hamid, A., Fadel, E., Dartevelle, P., Simonneau, G. Humbert, M. (2005) Splenectomy and chronic thromboembolic pulmonary hypertension. Thorax, 60, 1031 1034. (Pubitemid 41705472)
25. Jais, X., D'Armini, A.M., Jansa, P., Torbicki, A., Delcroix, M., Ghofrani, H.A., Hoeper, M.M., Lang, I.M., Mayer, E., Pepke-Zaba, J., Perchenet, L., Morganti, A., Simonneau, G. Rubin, L.J. (2008) Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial. Journal of the American College of Cardiology, 52, 2127 2134.
26. Kim, N.H., Fesler, P., Channick, R.N., Knowlton, K.U., Ben-Yehuda, O., Lee, S.H., Naeije, R. Rubin, L.J. (2004) Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Circulation, 109, 18 22. (Pubitemid 38056014)
27. Kyrle, P.A., Minar, E., Bialonczyk, C., Hirschl, M., Weltermann, A. Eichinger, S. (2004) The risk of recurrent venous thromboembolism in men and women. New England Journal of Medicine, 350, 2558 2563. (Pubitemid 38765133)
28. Laczika, K., Lang, I.M., Quehenberger, P., Mannhalter, C., Muhm, M., Klepetko, W. Kyrle, P.A. (2002) Unilateral chronic thromboembolic pulmonary disease associated with combined inherited thrombophilia. Chest, 121, 286 289. (Pubitemid 34114262)
29. Lang, I.M. (2004) Chronic thromboembolic pulmonary hypertension - not so rare after all. New England Journal of Medicine, 350, 2236 2238. (Pubitemid 38669205)
30. Lang, I.M., Marsh, J.J., Olman, M.A., Moser, K.M., Loskutoff, D.J. Schleef, R.R. (1994a) Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli. Circulation, 89, 2715 2721. (Pubitemid 24173692)
31. Lang, I.M., Marsh, J.J., Olman, M.A., Moser, K.M. Schleef, R.R. (1994b) Parallel analysis of tissue-type plasminogen activator and type 1 plasminogen activator inhibitor in plasma and endothelial cells derived from patients with chronic pulmonary thromboemboli. Circulation, 90, 706 712.
32. Lang, I.M., Klepetko, W. Pabinger, I. (1996a) No increased prevalence of the factor V Leiden mutation in chronic major vessel thromboembolic pulmonary hypertension (CTEPH). Thrombosis and Haemostasis, 76, 476 477.
33. Lang, I.M., Moser, K.M. Schleef, R.R. (1996b) Expression of Kunitz protease inhibitor - containing forms of amyloid beta-protein precursor within vascular thrombi. Circulation, 94, 2728 2734.
34. Le Gal, G., Delahousse, B., Lacut, K., Malaviolle, V., Regina, S., Blouch, M.T., Couturaud, F., Mottier, D., Oger, E. Gruel, Y. (2007) Fibrinogen Aalpha-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolism. Thrombosis Research, 121, 333 338.
35. Marsh, J.J., Konopka, R.G., Lang, I.M., Wang, H.Y., Pedersen, C., Chiles, P., Reilly, C.F. Moser, K.M. (1994) Suppression of thrombolysis in a canine model of pulmonary embolism. Circulation, 90, 3091 3097.
36. Modarai, B., Burnand, K.G., Humphries, J., Waltham, M. Smith, A. (2005) The role of neovascularisation in the resolution of venous thrombus. Thrombosis and Haemostasis, 93, 801 809. (Pubitemid 40691533)
37. Morris, T.A., Marsh, J.J., Chiles, P.G., Auger, W.R., Fedullo, P.F. Woods, Jr., V.L. (2006) Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis. American Journal of Respiratory and Critical Care Medicine, 173, 1270 1275.
38. Morris, T.A., Marsh, J.J., Chiles, P.G., Kim, N.H., Noskovack, K.J., Magana, M.M., Gruppo, R.A. Woods, Jr., V.L. (2007) Abnormally sialylated fibrinogen gamma-chains in a patient with chronic thromboembolic pulmonary hypertension. Thrombosis Research, 119, 257 259.
39. Morris, T.A., Marsh, J.J., Chiles, P.G., Magana, M.M., Liang, N.C., Soler, X., Desantis, D.J., Ngo, D. Woods, Jr., V.L. (2009) High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension. Blood, 114, 1929 1936.
40. Moser, K.M. Bloor, C.M. (1993) Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension. Chest, 103, 685 692.
41. Moser, K.M. Braunwald, N.S. (1973) Successful surgical intervention in severe chronic thromboembolic pulmonary hypertension. Chest, 64, 29 35.
42. Moser, K.M., Auger, W.R. Fedullo, P.F. (1990) Chronic major-vessel thromboembolic pulmonary hypertension. Circulation, 81, 1735 1743. (Pubitemid 20183821)
43. Ogawa, A., Firth, A.L., Yao, W., Madani, M.M., Kerr, K.M., Auger, W.R., Jamieson, S.W., Thistlethwaite, P.A. Yuan, J.X. (2009) Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology, 297, L666 L676.
44. Olman, M.A., Marsh, J.J., Lang, I.M., Moser, K.M., Binder, B.R. Schleef, R.R. (1992) Endogenous fibrinolytic system in chronic large-vessel thromboembolic pulmonary hypertension. Circulation, 86, 1241 1248.
45. Pengo, V., Lensing, A.W., Prins, M.H., Marchiori, A., Davidson, B.L., Tiozzo, F., Albanese, P., Biasiolo, A., Pegoraro, C., Iliceto, S. Prandoni, P. (2004) Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. New England Journal of Medicine, 350, 2257 2264. (Pubitemid 38669208)
46. Ribeiro, A., Lindmarker, P., Johnsson, H., Juhlin-Dannfelt, A. Jorfeldt, L. (1999) Pulmonary embolism: one-year follow-up with echocardiography doppler and five-year survival analysis. Circulation, 99, 1325 1330. (Pubitemid 29129917)
47. Schoenbaum, S.C., Gardner, P. Shillito, J. (1975) Infections of cerebrospinal fluid shunts: epidemiology, clinical manifestations, and therapy. Journal of Infectious Diseases, 131, 543 552.
48. Skoro-Sajer, N., Hack, N., Sadushi-Kolici, R., Bonderman, D., Jakowitsch, J., Klepetko, W., Hoda, M.A., Kneussl, M.P., Fedullo, P. Lang, I.M. (2009) Pulmonary vascular reactivity and prognosis in patients with chronic thromboembolic pulmonary hypertension: a pilot study. Circulation, 119, 298 305.
49. Suntharalingam, J., Goldsmith, K., van Marion, V., Long, L., Treacy, C.M., Dudbridge, F., Toshner, M.R., Pepke-Zaba, J., Eikenboom, J.C. Morrell, N.W. (2008) Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension. European Respiratory Journal, 31, 736 741.
50. Thomson, J.R., Machado, R.D., Pauciulo, M.W., Morgan, N.V., Humbert, M., Elliott, G.C., Ward, K., Yacoub, M., Mikhail, G., Rogers, P., Newman, J., Wheeler, L., Higenbottam, T., Gibbs, J.S., Egan, J., Crozier, A., Peacock, A., Allcock, R., Corris, P., Loyd, J.E., Trembath, R.C. Nichols, W.C. (2000) Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family. Journal of Medical Genetics, 37, 741 745.
51. Waltham, M., Burnand, K.G., Collins, M. Smith, A. (2000) Vascular endothelial growth factor and basic fibroblast growth factor are found in resolving venous thrombi. Journal of Vascular Surgery, 32, 988 996.
52. Waltham, M., Burnand, K.G., Collins, M., McGuinness, C.L., Singh, I. Smith, A. (2003) Vascular endothelial growth factor enhances venous thrombus recanalisation and organisation. Thrombosis and Haemostasis, 89, 169 176. (Pubitemid 36149806)
53. Wolf, M., Boyer-Neumann, C., Parent, F., Eschwege, V., Jaillet, H., Meyer, D. Simonneau, G. (2000) Thrombotic risk factors in pulmonary hypertension. European Respiratory Journal, 15, 395 399. (Pubitemid 30085971)
54. Yao, W., Firth, A.L., Sacks, R.S., Ogawa, A., Auger, W.R., Fedullo, P.F., Madani, M.M., Lin, G.Y., Sakakibara, N., Thistlethwaite, P.A., Jamieson, S.W., Rubin, L.J. Yuan, J.X. (2009) Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology, 296, L870 L878.