Chromatography-crystallization hybrid process for artemisinin purification from Artemisia annua

Chemical Engineering and Technology

Volumn 33, Issue 5, 2010, Pages 791-796

  Qu, Haiyan ^a   Christensen, Kathrine Bisgaard ^a   Fretté, Xavier C ^a   Tian, Fang ^b   Rantanen, Jukka ^b   Christensen, Lars Porskjær ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Artemisinin; Chromatography; Crystallization; Hybrid separation process

Indexed keywords

ACETONE SOLUTION; ANTI-SOLVENT CRYSTALLIZATION; ANTI-SOLVENTS; ARTEMISIA ANNUA; ARTEMISININ; CRUDE EXTRACT; CRYSTALLIZATION BEHAVIOR; DIFFERENT SOLVENTS; FEEDING RATE; FLASH COLUMN CHROMATOGRAPHY; HERBAL PLANTS; HYBRID PROCESS; HYBRID SEPARATION PROCESS; ISOLATION AND PURIFICATION; ORTHORHOMBIC FORMS; OSTWALD'S RULE OF STAGES; SOLVENT MIXTURES; STEP CRYSTALLIZATIONS; TRANSFORMATION MECHANISMS; TRICLINIC FORMS;

ACETONE; ACETONITRILE; CRYSTALLIZATION; FEEDING; POLYMORPHISM; PURIFICATION; SOLVENTS;

COLUMN CHROMATOGRAPHY;

ARTEMISIA ANNUA;

EID: 77951670554     PISSN: 09307516     EISSN: 15214125     Source Type: Journal    
DOI: 10.1002/ceat.200900575     Document Type: Article

References (10)

1. X. D. Luo, C. C. Shen, Med. Res. Rev. 1987, 7, 29.
2. G. A. Balint, Pharmacol. Ther. 2001, 90, 261.
3. V. Dhingra, K. V. Rao, M. L. Narasu, Life Sci. 2000, 44, 279.
4. S. Oh et al., Cancer Lett. 2009, 274, 33.
5. M. A. Avery, C. Jennings-White, W. K. M. Chong, Tetrahedron Lett. 1987, 28, 4629.
6. A. A. Lapkin et al., J. Pharm. Biomed. Anal. 2009, 49, 908.
7. K. Grevsen, M. Jensen, X. C. Fretté, J. J. Henriksen, Artemisia annua Anti-Malaria Project in Vietnam, Report No. 1, Danish Institute of Agricultural Sciences, Development Center Aarslev, Denmark 2006.
8. K. Y. Fung, K. M. Ng, C. Wibowo, Ind. Eng. Chem. Res. 2005, 44,910.
9. H. Lorenz, P. Sheehan, A. Seidel-Morgenstern. J. Chromatogr. A 2001, 908, 201.
10. K.-L. Chan et al., Phytochemistry 1997, 46, 1209.