First Identification of an Antigen in Autoimmune Idiopathic Membranous Nephropathy: Toward Targeted Therapy?

American Journal of Kidney Diseases

Volumn 55, Issue 5, 2010, Pages 820-823

  Ronco, Pierre ^a   Debiec, Hanna ^a  

^a SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD20 ANTIBODY; COMPLEMENT MEMBRANE ATTACK COMPLEX; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; MEMBRANE METALLOENDOPEPTIDASE; PHOSPHOLIPASE A2 RECEPTOR;

ALLOIMMUNIZATION; ANTIBODY DETECTION; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONFOCAL MICROSCOPY; DISEASE MODEL; EDITORIAL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IDIOPATHIC DISEASE; IMMUNE RESPONSE; KIDNEY FAILURE; MEMBRANOUS GLOMERULONEPHRITIS; NONHUMAN; PATHOGENESIS; PODOCYTE; PROTEINURIA; REMISSION;

EID: 77951666624     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2009.09.017     Document Type: Editorial

References (26)

1. Wasserstein A.G. Membranous glomerulonephritis. J Am Soc Nephrol. 8 4 (1997) 664-674
2. Glassock R.J. Diagnosis and natural course of MN. Semin Nephrol. 23 4 (2003) 324-332
3. Imai H., Hamai K., Komatsuda A., Ohtani H., and Miura A.B. IgG subclasses in patients with membranoproliferative glomerulonephritis, MN, and lupus nephritis. Kidney Int. 51 1 (1997) 270-276
4. Kuroki A., Shibata T., Honda H., Totsuka D., Kobayashi K., and Sugisaki T. Glomerular and serum IgG subclasses in diffuse proliferative lupus nephritis, membranous lupus nephritis, and idiopathic membranous nephropathy. Int Med. 41 11 (2002) 936-942
5. Glassock R.J. The treatment of idiopathic membranous nephropathy: a dilemma or a conundrum?. Am J Kidney Dis. 44 3 (2004) 562-566
6. Perna A., Schieppati A., Zamora J., et al. Immunosuppressive treatment for idiopathic membranous nephropathy: a systematic review. Am J Kidney Dis. 44 3 (2004) 385-401
7. Ruggenenti P., Chiurchiu C., Brusegan V., et al. Rituximab in idiopathic membranous nephropathy: a one-year prospective study. J Am Soc Nephrol. 14 7 (2003) 1851-1857
8. Cunningham P.N., and Quigg R.J. Contrasting roles of complement activation and its regulation in membranous nephropathy. J Am Soc Nephrol. 16 5 (2005) 1214-1222
9. Heymann W., Hackel D.B., Harwood S., Wilson S.G.F., and Hunter J.L. Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspension. Proc Soc Exp Biol Med. 100 4 (1959) 660-664
10. Kerjaschki D., and Farquhar M.G. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci U S A 79 18 (1982) 5557-5561
11. Kerjaschki D., and Farquhar M.G. Immunocytochemical localization of the Heymann nephritis antigen (gp330) in glomerular epithelial cells of normal Lewis rats. J Exp Med. 157 2 (1983) 667-686
12. Debiec H., Guigonis V., Mougenot B., et al. Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med. 346 26 (2002) 2053-2060
13. Debiec H., Nauta J., Coulet F., et al. Role of truncating mutations in MME gene in fetomaternal alloimmunization and antenatal glomerulopathies. Lancet 364 9441 (2004) 1252-1259
14. Beck Jr. L.H., Bonegio R.G., Lambeau G., et al. M-Type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 361 1 (2009) 11-21
15. Hellmark T., Burkhardt H., and Wieslander J. Goodpasture disease. Characterization of a single conformational epitope as the target of pathogenic autoantibodies. J Biol Chem. 274 36 (1999) 25862-25868
16. Hudson B.G. The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family. J Am Soc Nephrol. 15 10 (2004) 2514-2527
17. Kain R., Exner M., Brandes R., et al. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med. 14 10 (2008) 1088-1096
18. Shah P., Tramontano A., and Makker S.P. Intramolecular epitope spreading in Heymann nephritis. J Am Soc Nephrol. 18 12 (2007) 3060-3066
19. Lundberg K., and Venables P.J. Epitope spreading in animal models: array of hope in rheumatoid arthritis and multiple sclerosis. Arthritis Res Ther. 10 6 (2008) 122-123
20. Chen L., Hellmark T., Pedchenko V., et al. A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis. J Am Soc Nephrol. 17 11 (2006) 3076-3081
21. Zanetti M., and Druet P. Passive Heymann's nephritis as a model of immune glomerulonephritis mediated by antibodies to immunoglobulins. Clin Exp Immunol. 41 2 (1980) 189-195
22. Hennig C., Rink L., and Kirchner H. Evidence for presence of IgG4 anti-immunoglobulin autoantibodies in all human beings. Lancet 355 9215 (2000) 1617-1618
23. Aalberse R.C., and Schuurman J. IgG4 breaking the rules. Immunology 105 (2002) 9-19
24. Penny M.J., Boyd R.A., and Hall B.M. Permanent CD8(+) T cell depletion prevents proteinuria in active Heymann nephritis. J Exp Med. 188 10 (1998) 1775-1784
25. Reynolds J., Prodromidi E.I., Juggapah J.K., et al. Nasal administration of recombinant rat alpha3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis in the WKY rat. J Am Soc Nephrol. 16 5 (2005) 1350-1359
26. Reynolds J., Abbott D.S., Karegli J., Evans D.J., and Pusey C.D. Mucosal tolerance induced by an immunodominant peptide from rat alpha3(IV)NC1 in established experimental autoimmune glomerulonephritis. Am J Pathol. 174 6 (2009) 2202-2210