메뉴 건너뛰기




Volumn 12, Issue 2, 2010, Pages 81-91

Chemotherapy-induced peripheral neuropathy: Clinical features, diagnosis, prevention and treatment strategies

Author keywords

Cancer; Chemotherapy; Neuropathy; Neuroprotection; Pain; Polyneuropathy

Indexed keywords

21 AMINOEPOTHILONE B; ALKYLATING AGENT; AM 424; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; CISPLATIN; CYTARABINE; DIMESNA; EPOTHILONE B; EPOTHILONE D; EPOTHILONE DERIVATIVE; ETOPOSIDE; GEMCITABINE; GLUTATHIONE; IXABEPILONE; LAMOTRIGINE; LENALIDOMIDE; NEUROPROTECTIVE AGENT; OXALIPLATIN; PACLITAXEL; PLATINUM COMPLEX; PROTEASOME INHIBITOR; SAGOPILONE; TAXANE DERIVATIVE; THALIDOMIDE; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCA ALKALOID; VINCRISTINE; VINDESINE; PLATINUM DERIVATIVE; VITAMIN;

EID: 77951649382     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/S12094-010-0474-z     Document Type: Review
Times cited : (143)

References (90)
  • 1
    • 33846782923 scopus 로고    scopus 로고
    • Neuroprotection during chemotherapy: A systematic review
    • Walker M, Ni O (2007) Neuroprotection during chemotherapy: a systematic review. Am J Clin Oncol 30:82-92
    • (2007) Am J Clin Oncol , vol.30 , pp. 82-92
    • Walker, M.1    Ni, O.2
  • 2
    • 0028048725 scopus 로고
    • Long-term peripheral neurotoxicity of cisplatin in patients with successfully treated epithelial ovarian cancer
    • Cavaletti G, Bogliun G, Marzorati L et al (1994) Long-term peripheral neurotoxicity of cisplatin in patients with successfully treated epithelial ovarian cancer. Anticancer Res 14:1287-1292
    • (1994) Anticancer Res , vol.14 , pp. 1287-1292
    • Cavaletti, G.1    Bogliun, G.2    Marzorati, L.3
  • 3
    • 34247383061 scopus 로고    scopus 로고
    • Management of complications of chemotherapy
    • Gershenson DM, McGuire MP, Gore M et al (eds). Elsevier Science, Philadelphia, PA
    • Mileshkin L, Antil Y, Rischin D (2002) Management of complications of chemotherapy. In: Gershenson DM, McGuire MP, Gore M et al (eds) Gynaecologic cancer: controversies in management. Elsevier Science, Philadelphia, PA
    • (2002) Gynaecologic Cancer: Controversies in Management
    • Mileshkin, L.1    Antil, Y.2    Rischin, D.3
  • 4
    • 45949131693 scopus 로고    scopus 로고
    • Chemotherapy- induced neuropathy: Prevention and treatment strategies
    • Wolf S, Barton D, Kottschade L et al (2008) Chemotherapy- induced neuropathy: prevention and treatment strategies. Eur J Cancer 44:1507-1515
    • (2008) Eur J Cancer , vol.44 , pp. 1507-1515
    • Wolf, S.1    Barton, D.2    Kottschade, L.3
  • 5
    • 33749051832 scopus 로고    scopus 로고
    • Development of neuropathy in patients with myeloma treated with thalidomide: Patterns of occurrence and the role of electrophysiologic monitoring
    • Mileshkin L, Stark R, Day B et al (2006) Development of neuropathy in patients with myeloma treated with thalidomide: patterns of occurrence and the role of electrophysiologic monitoring. J Clin Oncol 24:4507-4514
    • (2006) J Clin Oncol , vol.24 , pp. 4507-4514
    • Mileshkin, L.1    Stark, R.2    Day, B.3
  • 6
    • 77952491776 scopus 로고    scopus 로고
    • Nerve changes in patients who are undergoing chemotherapy or biological therapy for cancer
    • National Cancer Institute (NCI). National Library of Medicine (US), Bethesda, MD. 2000-20091219. Available from
    • National Cancer Institute (NCI) (2006) Nerve changes in patients who are undergoing chemotherapy or biological therapy for cancer. In: ClinicalTrials.gov [Internet]. National Library of Medicine (US), Bethesda, MD. 2000-20091219. Available from: http://clinicaltrials.gov/ct2/show/NCT00281853?term= cancer+AND+neuropathy&rank=33
    • (2006) ClinicalTrials.gov [Internet]
  • 7
    • 77952511016 scopus 로고    scopus 로고
    • Chemotherapyinduced peripheral neuropathy survey
    • MD Anderson Cancer. National Library of Medicine (US), Bethesda, MD. 2000-20091219. Available from
    • MD Anderson Cancer (2009) Chemotherapyinduced peripheral neuropathy survey. In: ClinicalTrials. gov [Internet]. National Library of Medicine (US), Bethesda, MD. 2000-20091219. Available from: http://clinicaltrials.gov/ct2/show/ NCT01016028?term=cancer+AND+neuropathy&rank=14
    • (2009) ClinicalTrials. Gov [Internet]
  • 8
    • 33845609134 scopus 로고    scopus 로고
    • Gross anatomy of the peripheral nervous system
    • Dyck PJ, Thomas PK (eds), 4th edn. Elsevier, Philadelphia
    • Gardner ED, Bunge RP (2005) Gross anatomy of the peripheral nervous system. In: Dyck PJ, Thomas PK (eds) Peripheral neuropathy, 4th edn. Elsevier, Philadelphia, pp 11-34
    • (2005) Peripheral Neuropathy , pp. 11-34
    • Gardner, E.D.1    Bunge, R.P.2
  • 9
    • 34548533202 scopus 로고    scopus 로고
    • Microscopic anatomy of the peripheral nervous system
    • Dyck PJ, Thomas PK (eds), 4th edn. Elsevier, Philadelphia
    • Berthold SH, Fraher JP, King RHM et al (2005) Microscopic anatomy of the peripheral nervous system. In: Dyck PJ, Thomas PK (eds) Peripheral neuropathy, 4th edn. Elsevier, Philadelphia, pp 35-91
    • (2005) Peripheral Neuropathy , pp. 35-91
    • Berthold, S.H.1    Fraher, J.P.2    King, R.H.M.3
  • 10
    • 65249107203 scopus 로고    scopus 로고
    • Microtubule assembly, organization and dynamics in axons and dendrites
    • Cecilia Conde C, Cáceres A (2009) Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci 10:319-332
    • (2009) Nat Rev Neurosci , vol.10 , pp. 319-332
    • Cecilia Conde, C.1    Cáceres, A.2
  • 11
    • 56849090332 scopus 로고    scopus 로고
    • Peripheral nerve diseases
    • Hughes R (2008) Peripheral nerve diseases. Pract Neurol 8:396-405
    • (2008) Pract Neurol , vol.8 , pp. 396-405
    • Hughes, R.1
  • 12
    • 70349849040 scopus 로고    scopus 로고
    • Concepto de dolor neuropático
    • Serra Catafau J (ed.). Médica Panamericana, Madrid
    • Serra Catafau J (2006) Concepto de dolor neuropático. In: Serra Catafau J (ed.) Dolor neuropático. Médica Panamericana, Madrid, pp 17-26
    • (2006) Dolor Neuropático , pp. 17-26
    • Serra Catafau, J.1
  • 13
    • 46849105270 scopus 로고    scopus 로고
    • The diagnostic criteria for small fibre neuropathy: From symptoms to neuropathology
    • Devigili G, Tugnoli V, Penza P et al (2008) The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain 131:1912-1925
    • (2008) Brain , vol.131 , pp. 1912-1925
    • Devigili, G.1    Tugnoli, V.2    Penza, P.3
  • 14
    • 56849090332 scopus 로고    scopus 로고
    • Peripheral nerve diseases
    • Hughes R (2008) Peripheral nerve diseases. Pract Neurol 8:396-405
    • (2008) Pract Neurol , vol.8 , pp. 396-405
    • Hughes, R.1
  • 16
    • 0031791493 scopus 로고    scopus 로고
    • Measuring vibration threshold with a graduated tuning fork in normal aging and in patients with polyneuropathy
    • For the European Inflammatory Neuropathy Cause and Treatment (INCAT) group
    • Martina IS, van Koningsveld R, Schmitz PI et al (1998) For the European Inflammatory Neuropathy Cause and Treatment (INCAT) group. Measuring vibration threshold with a graduated tuning fork in normal aging and in patients with polyneuropathy. J Neurol Neurosurg Psychiatry 65:743-747
    • (1998) J Neurol Neurosurg Psychiatry , vol.65 , pp. 743-747
    • Martina, I.S.1    Van Koningsveld, R.2    Schmitz, P.I.3
  • 17
    • 60549088718 scopus 로고    scopus 로고
    • Is the bedside timed vibration test reliable?
    • Botez SA, Liu G, Logigian E et al (2009) Is the bedside timed vibration test reliable? Muscle Nerve 39:221-223
    • (2009) Muscle Nerve , vol.39 , pp. 221-223
    • Botez, S.A.1    Liu, G.2    Logigian, E.3
  • 18
    • 55249098653 scopus 로고    scopus 로고
    • Thalidomide and sensory neurotoxicity: A neurophysiological study
    • Zara G, Ermani M, Rondinone R et al (2008) Thalidomide and sensory neurotoxicity: a neurophysiological study. J Neurol Neurosurg Psychiatry 79:1258-1261
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 1258-1261
    • Zara, G.1    Ermani, M.2    Rondinone, R.3
  • 19
    • 0033946726 scopus 로고    scopus 로고
    • Grading of chemotherapy- induced peripheral neuropathy
    • Postma TJ, Heimans JJ (2000) Grading of chemotherapy- induced peripheral neuropathy. Ann Oncol 11:509-513
    • (2000) Ann Oncol , vol.11 , pp. 509-513
    • Postma, T.J.1    Heimans, J.J.2
  • 20
    • 0037102328 scopus 로고    scopus 로고
    • Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advance colorectal cancer: A randomized, double-blind, placebo- controlled trial
    • Cascinu S, Catalano V, Cordella L et al (2002) Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advance colorectal cancer: a randomized, double-blind, placebo- controlled trial. J Clin Oncol 20:3478-3483
    • (2002) J Clin Oncol , vol.20 , pp. 3478-3483
    • Cascinu, S.1    Catalano, V.2    Cordella, L.3
  • 21
    • 70349956408 scopus 로고    scopus 로고
    • Oxaliplatin- induced neurotoxicity: Changes in axonal excitability precede development of neuropathy
    • Park SB, Lin CS-Y, Krishnan AV et al (2009) Oxaliplatin- induced neurotoxicity: changes in axonal excitability precede development of neuropathy. Brain 132:2712-2723
    • (2009) Brain , vol.132 , pp. 2712-2723
    • Park, S.B.1    Lin, C.S.-Y.2    Krishnan, A.V.3
  • 22
    • 33749051832 scopus 로고    scopus 로고
    • Aparición de neuropatía en los pacientes con mieloma tratados con talidomida: Patrones de aparición y utilidad de la monitorización electrofisiológica
    • Mileshkin L, Stark R, Day B et al (2006) Aparición de neuropatía en los pacientes con mieloma tratados con talidomida: patrones de aparición y utilidad de la monitorización electrofisiológica. J Clin Oncol 24:4507-4514
    • (2006) J Clin Oncol , vol.24 , pp. 4507-4514
    • Mileshkin, L.1    Stark, R.2    Day, B.3
  • 23
    • 2442571156 scopus 로고    scopus 로고
    • Technology literature review: Quantitative sensory testing
    • American Association of Electrodiagnostic Medicine
    • American Association of Electrodiagnostic Medicine (2004) Technology literature review: quantitative sensory testing. Muscle Nerve 29:734-747
    • (2004) Muscle Nerve , vol.29 , pp. 734-747
  • 24
    • 62449148084 scopus 로고    scopus 로고
    • Acute abnormalities of sensory nerve function associated with oxaliplatin-induced neurotoxicity
    • Park SB, Goldstein D, Lin CS-Y et al (2009) Acute abnormalities of sensory nerve function associated with oxaliplatin-induced neurotoxicity. J Clin Oncol 27:1243-1249
    • (2009) J Clin Oncol , vol.27 , pp. 1243-1249
    • Park, S.B.1    Goldstein, D.2    Lin, C.S.-Y.3
  • 25
    • 60749134528 scopus 로고    scopus 로고
    • Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies
    • Park SB, Krishnan AV, Lin CS-Y et al (2008) Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies. Curr Med Chem 15:3081-3094
    • (2008) Curr Med Chem , vol.15 , pp. 3081-3094
    • Park, S.B.1    Krishnan, A.V.2    Lin, C.S.-Y.3
  • 26
    • 60549087533 scopus 로고    scopus 로고
    • Evaluation of distal symmetric polyneuropathy: The role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review)
    • England JD, Gronseth GS, Franklin G et al (2009) Evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Muscle Nerve 39:106-115
    • (2009) Muscle Nerve , vol.39 , pp. 106-115
    • England, J.D.1    Gronseth, G.S.2    Franklin, G.3
  • 27
    • 53549131958 scopus 로고    scopus 로고
    • Skin biopsy as a diagnostic tool
    • Sommer C (2008) Skin biopsy as a diagnostic tool. Curr Opin Neurol 21:563-568
    • (2008) Curr Opin Neurol , vol.21 , pp. 563-568
    • Sommer, C.1
  • 28
    • 34948894464 scopus 로고    scopus 로고
    • Skin biopsy as a diagnostic tool in peripheral neuropathy
    • DOI 10.1038/ncpneuro0630, PII NCPNEURO0630
    • Lauria G, Devigili G (2007) Skin biopsy as a diagnostic tool in peripheral neuropathy. Nat Clin Pract Neurol 3:546-557 (Pubitemid 47528029)
    • (2007) Nature Clinical Practice Neurology , vol.3 , Issue.10 , pp. 546-557
    • Lauria, G.1    Devigili, G.2
  • 29
    • 34250223040 scopus 로고    scopus 로고
    • Skin biopsy: A new tool for diagnosing peripheral neuropathy
    • DOI 10.1136/bmj.39192.488125.BE
    • Lauria G, Lombardi R (2007) Skin biopsy: a new tool for diagnosing peripheral neuropathy. BMJ 334:1159-1162 (Pubitemid 46910023)
    • (2007) British Medical Journal , vol.334 , Issue.7604 , pp. 1159-1162
    • Lauria, G.1    Lombardi, R.2
  • 30
    • 77952503048 scopus 로고    scopus 로고
    • Skin biopsies in chemotherapy-induced neuropathy
    • Erasmus Medical Center. National Library of Medicine (US), Bethesda, MD. 2000-20091219. Available from
    • Erasmus Medical Center (2010) Skin biopsies in chemotherapy-induced neuropathy. In: Clinical- Trials.gov [Internet]. National Library of Medicine (US), Bethesda, MD. 2000-20091219. Available from: http://clinicaltrials.gov/ ct2/show?term=cancer+AND+neuropathy&rank=34
    • (2010) Clinical- Trials.gov [Internet]
  • 31
    • 34247105821 scopus 로고    scopus 로고
    • Perfil farmacogenético en los pacientes con cancer colorrectalavanzado tratados con quimioterapia FOLFOX-4 de primera línea
    • Ruzzo A, Graziano F, Loupakis F et al (2007) Perfil farmacogené tico en los pacientes con cancer colorrectalavanzado tratados con quimioterapia FOLFOX-4 de primera línea. J Clin Oncol 25:1247-1254
    • (2007) J Clin Oncol , vol.25 , pp. 1247-1254
    • Ruzzo, A.1    Graziano, F.2    Loupakis, F.3
  • 32
    • 77952486061 scopus 로고    scopus 로고
    • Pharmacogenomic study to predict neurotoxicity of oxaliplatin
    • Samsung Medical Center. National Library of Medicine (US), Bethesda, MD. 2000-20091220. Available from
    • Samsung Medical Center (2009) Pharmacogenomic study to predict neurotoxicity of oxaliplatin. In: ClinicalTrials.gov [Internet]. National Library of Medicine (US), Bethesda, MD. 2000-20091220. Available from: http://clinicaltrials.gov/ct2/show/NCT00977717?term= neuropathy+and+chemotherapy&rank=32
    • (2009) ClinicalTrials.gov [Internet]
  • 33
    • 45949131693 scopus 로고    scopus 로고
    • Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies
    • Wolf S, Barton D, Kottschade L et al (2008) Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. Eur J Cancer 44:1507-1515
    • (2008) Eur J Cancer , vol.44 , pp. 1507-1515
    • Wolf, S.1    Barton, D.2    Kottschade, L.3
  • 34
    • 33645736326 scopus 로고    scopus 로고
    • Peripheral neuropathy induced by microtubule-stabilizing agents
    • Lee JJ, Swain SM (2006) Peripheral neuropathy induced by microtubule-stabilizing agents. J Clin Oncol 24:1633-1642
    • (2006) J Clin Oncol , vol.24 , pp. 1633-1642
    • Lee, J.J.1    Swain, S.M.2
  • 35
    • 20944441476 scopus 로고    scopus 로고
    • Phase II trial of the novel taxane BMS-184476 as second- line in non-small-cell lung cancer
    • Camps C, Felip E, Sanchez JM et al (2005) Phase II trial of the novel taxane BMS-184476 as second- line in non-small-cell lung cancer. Ann Oncol 16:597-601
    • (2005) Ann Oncol , vol.16 , pp. 597-601
    • Camps, C.1    Felip, E.2    Sanchez, J.M.3
  • 36
    • 33747689092 scopus 로고    scopus 로고
    • A Phase II trial of epothilone B analogue BMS- 247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: A Southwest Oncology Group study
    • Whitehead RP, McCoy S, Rivkin SE et al (2006) A Phase II trial of epothilone B analogue BMS- 247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: a Southwest Oncology Group study. Invest New Drugs 24:515-520
    • (2006) Invest New Drugs , vol.24 , pp. 515-520
    • Whitehead, R.P.1    McCoy, S.2    Rivkin, S.E.3
  • 37
    • 0035914257 scopus 로고    scopus 로고
    • Nucleolar damage correlates with neurotoxicity induced by different platinum drugs
    • McKeage MJ, Hsu T, Screnci D et al (2001) Nucleolar damage correlates with neurotoxicity induced by different platinum drugs. Br J Cancer 85:1219-1225
    • (2001) Br J Cancer , vol.85 , pp. 1219-1225
    • McKeage, M.J.1    Hsu, T.2    Screnci, D.3
  • 38
    • 64049084475 scopus 로고    scopus 로고
    • Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli
    • Ta LE, Low PA, Windebank AJ (2009) Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli. Mol Pain 26:5-9
    • (2009) Mol Pain , vol.26 , pp. 5-9
    • Ta, L.E.1    Low, P.A.2    Windebank, A.J.3
  • 39
    • 0032526263 scopus 로고    scopus 로고
    • Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle
    • Gill JS, Windebank AJ (1998) Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle. J Clin Invest 101:2842-2850
    • (1998) J Clin Invest , vol.101 , pp. 2842-2850
    • Gill, J.S.1    Windebank, A.J.2
  • 41
    • 34648841045 scopus 로고    scopus 로고
    • Treatment options for the management of diabetic painful neuropathy: Best current evidence
    • McKeage K (2007) Treatment options for the management of diabetic painful neuropathy: best current evidence. Curr Opin Neurol 20:553-557
    • (2007) Curr Opin Neurol , vol.20 , pp. 553-557
    • McKeage, K.1
  • 42
    • 0038786708 scopus 로고    scopus 로고
    • The enteric nervous system III: A target for pharmacological treatment
    • Hansen MB (2003) The enteric nervous system III: a target for pharmacological treatment. Pharmacol Toxicol 93:1-13
    • (2003) Pharmacol Toxicol , vol.93 , pp. 1-13
    • Hansen, M.B.1
  • 43
    • 33646241993 scopus 로고    scopus 로고
    • Axonal function and activity-dependent excitability changes in myotonic dystrophy
    • Krishnan AV, Kiernan MC (2006) Axonal function and activity-dependent excitability changes in myotonic dystrophy. Muscle Nerve 33:627-636
    • (2006) Muscle Nerve , vol.33 , pp. 627-636
    • Krishnan, A.V.1    Kiernan, M.C.2
  • 44
    • 0028885057 scopus 로고
    • Comparative adverse effect profiles of platinum drugs
    • McKeage MJ (1995) Comparative adverse effect profiles of platinum drugs. Drug Saf 13:228-244
    • (1995) Drug Saf , vol.13 , pp. 228-244
    • McKeage, M.J.1
  • 46
    • 0348109345 scopus 로고    scopus 로고
    • Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by timelapse imaging in vivo
    • Pan YA, Misgeld T, Lichtman JW et al (2003) Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by timelapse imaging in vivo. J Neurosci 23:11479-11488
    • (2003) J Neurosci , vol.23 , pp. 11479-11488
    • Pan, Y.A.1    Misgeld, T.2    Lichtman, J.W.3
  • 47
    • 0038345540 scopus 로고    scopus 로고
    • Bilateral hearing loss during vincristine therapy: A case report
    • Kalcioglu MT, Kuku I, Kaya E et al (2003) Bilateral hearing loss during vincristine therapy: a case report. J Chemother 15:290-292
    • (2003) J Chemother , vol.15 , pp. 290-292
    • Kalcioglu, M.T.1    Kuku, I.2    Kaya, E.3
  • 48
    • 15244346675 scopus 로고    scopus 로고
    • Dose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worsening
    • Verstappen CC, Koeppen S, Heimans JJ et al (2005) Dose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worsening. Neurology 64:1076-1077
    • (2005) Neurology , vol.64 , pp. 1076-1077
    • Verstappen, C.C.1    Koeppen, S.2    Heimans, J.J.3
  • 49
    • 70449484336 scopus 로고    scopus 로고
    • Peripheral neuropathy in survivors of childhood acute lymphoblastic leukemia
    • Ramchandren S, Leonard M, Mody RJ et al (2009) Peripheral neuropathy in survivors of childhood acute lymphoblastic leukemia. J Peripher Nerv Syst 14:184-189
    • (2009) J Peripher Nerv Syst , vol.14 , pp. 184-189
    • Ramchandren, S.1    Leonard, M.2    Mody, R.J.3
  • 50
    • 36349031206 scopus 로고    scopus 로고
    • Bortezomibinduced peripheral neurotoxicity: Still far from a painless gain
    • Cavaletti G, Nobile-Orazio E (2007) Bortezomibinduced peripheral neurotoxicity: still far from a painless gain. Haematologica 92:1308-1310
    • (2007) Haematologica , vol.92 , pp. 1308-1310
    • Cavaletti, G.1    Nobile-Orazio, E.2
  • 53
    • 69949096727 scopus 로고    scopus 로고
    • Mechanism of action of lenalidomide in hematological malignancies
    • Kotla V, Goel S, Nischal S et al (2009) Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol 2:36
    • (2009) J Hematol Oncol , vol.2 , pp. 36
    • Kotla, V.1    Goel, S.2    Nischal, S.3
  • 54
    • 0029823616 scopus 로고    scopus 로고
    • Acute polyneuropathy after high dose cytosine arabinoside in patients with leukemia
    • Openshaw H, Slatkin NE, Stein AS et al (1996) Acute polyneuropathy after high dose cytosine arabinoside in patients with leukemia. Cancer 78:1899-1905
    • (1996) Cancer , vol.78 , pp. 1899-1905
    • Openshaw, H.1    Slatkin, N.E.2    Stein, A.S.3
  • 56
    • 0020082277 scopus 로고
    • Possible enhancement of vincristine neuropathy by VP-16
    • Thant M, Hawley RJ, Smith MT et al (1982) Possible enhancement of vincristine neuropathy by VP-16. Cancer 1:859-864
    • (1982) Cancer , vol.1 , pp. 859-864
    • Thant, M.1    Hawley, R.J.2    Smith, M.T.3
  • 57
    • 0032574139 scopus 로고    scopus 로고
    • Gemcitabine-associated autonomic neuropathy
    • Dormann AJ, Grunewald T, Wigginghaus B et al (1998) Gemcitabine- associated autonomic neuropathy. Lancet 351:644
    • (1998) Lancet , vol.351 , pp. 644
    • Dormann, A.J.1    Grunewald, T.2    Wigginghaus, B.3
  • 58
    • 73349106835 scopus 로고    scopus 로고
    • Optic neuropathy in patients with glioblastoma receiving bevacizumab
    • Sherman JE, Aregawi MD, Lai A, Fathallah- Shaykh M (2009) Optic neuropathy in patients with glioblastoma receiving bevacizumab. Neurology 73:1924-1926
    • (2009) Neurology , vol.73 , pp. 1924-1926
    • Sherman, J.E.1    Aregawi, M.D.2    Lai, A.3    Fathallah-Shaykh, M.4
  • 59
    • 38349059232 scopus 로고    scopus 로고
    • Tipifarnib in acute myeloid leukemia
    • Burnett AK, Kell J (2007) Tipifarnib in acute myeloid leukemia. Drugs Today (Barc) 43:795-800
    • (2007) Drugs Today (Barc) , vol.43 , pp. 795-800
    • Burnett, A.K.1    Kell, J.2
  • 60
    • 33747644424 scopus 로고    scopus 로고
    • A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma: NCIC CTG IND.145
    • Kovacs MJ, Reece DE, Marcellus D et al (2006) A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma: NCIC CTG IND.145. Invest New Drugs 24:529-535
    • (2006) Invest New Drugs , vol.24 , pp. 529-535
    • Kovacs, M.J.1    Reece, D.E.2    Marcellus, D.3
  • 62
    • 73349119712 scopus 로고    scopus 로고
    • Malnutrition associated with increased risk of peripheral neuropathy in Peruvian children with HIV infection
    • Esteban PM, Thahn TG, Bravo JF et al (2009) Malnutrition associated with increased risk of peripheral neuropathy in Peruvian children with HIV infection. J Acquir Immune Defic Syndr 52:656-658
    • (2009) J Acquir Immune Defic Syndr , vol.52 , pp. 656-658
    • Esteban, P.M.1    Thahn, T.G.2    Bravo, J.F.3
  • 63
    • 77952513684 scopus 로고    scopus 로고
    • Vincristine induced neurotoxicity in cancer patients
    • published online
    • Gomber S, Dewan P, Chhonker D (2009) Vincristine induced neurotoxicity in cancer patients. Indian J Pediatr (published online)
    • (2009) Indian J Pediatr
    • Gomber, S.1    Dewan, P.2    Chhonker, D.3
  • 64
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M et al (2000) Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18:2938-2947
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • De Gramont, A.1    Figer, A.2    Seymour, M.3
  • 65
    • 9744230871 scopus 로고    scopus 로고
    • OPTIMOX study: FOLFOX7/LV5FU2 compared to FOLFOX4 in patients with advanced colorectal cancer
    • de Gramont A, Cervantes A, Andre T et al (2004) OPTIMOX study: FOLFOX7/LV5FU2 compared to FOLFOX4 in patients with advanced colorectal cancer. J Clin Oncol 22:3525
    • (2004) J Clin Oncol , vol.22 , pp. 3525
    • De Gramont, A.1    Cervantes, A.2    Andre, T.3
  • 66
    • 22944485043 scopus 로고    scopus 로고
    • Acetyl-L-carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties
    • Ghirardi O, Lo Giudice P, Pisano C et al (2005) Acetyl-L-carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties. Anticancer Res 25:2681-2687
    • (2005) Anticancer Res , vol.25 , pp. 2681-2687
    • Ghirardi, O.1    Lo Giudice, P.2    Pisano, C.3
  • 67
    • 23644441128 scopus 로고    scopus 로고
    • Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine
    • Bianchi G, Vitali G, Caraceni A et al (2005) Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine. Eur J Cancer 41:1746-1750
    • (2005) Eur J Cancer , vol.41 , pp. 1746-1750
    • Bianchi, G.1    Vitali, G.2    Caraceni, A.3
  • 68
    • 0034019630 scopus 로고    scopus 로고
    • Compartmentation of brain glutamate metabolism in neurons and glia
    • Daikhin Y, Yudkoff M (2000) Compartmentation of brain glutamate metabolism in neurons and glia. J Nutr 130:1026S-1031S
    • (2000) J Nutr , vol.130
    • Daikhin, Y.1    Yudkoff, M.2
  • 69
    • 0037294326 scopus 로고    scopus 로고
    • Amelioration of docetaxel/cisplatin induced polyneuropathy by alpha-lipoic acid
    • Gedlicka C, Kornek GV, Schmid K et al (2003) Amelioration of docetaxel/cisplatin induced polyneuropathy by alpha-lipoic acid. Ann Oncol 14:339-340
    • (2003) Ann Oncol , vol.14 , pp. 339-340
    • Gedlicka, C.1    Kornek, G.V.2    Schmid, K.3
  • 70
    • 0037457391 scopus 로고    scopus 로고
    • Alpha-tocopherol protects against cisplatin-induced toxicity without interfering with antitumor efficacy
    • Leonetti C, Biroccio A, Gabellini C et al (2003) Alpha-tocopherol protects against cisplatin-induced toxicity without interfering with antitumor efficacy. Int J Cancer 104:243-250
    • (2003) Int J Cancer , vol.104 , pp. 243-250
    • Leonetti, C.1    Biroccio, A.2    Gabellini, C.3
  • 71
    • 33845454129 scopus 로고    scopus 로고
    • A randomized controlled trial evaluating the efficacy and safety of vitamin e supplementation for protection against cisplatin-induced peripheral neuropathy: Final results
    • Argyriou AA, Chroni E, Koutras A et al (2006) A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results. Support Care Cancer 14:1134-1140
    • (2006) Support Care Cancer , vol.14 , pp. 1134-1140
    • Argyriou, A.A.1    Chroni, E.2    Koutras, A.3
  • 72
    • 1842421979 scopus 로고    scopus 로고
    • Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double- blind randomized trial
    • Ferreira PR, Fleck JF, Diehl A et al (2004) Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: a double- blind randomized trial. Head Neck 26:313-321
    • (2004) Head Neck , vol.26 , pp. 313-321
    • Ferreira, P.R.1    Fleck, J.F.2    Diehl, A.3
  • 73
    • 77952540535 scopus 로고    scopus 로고
    • Alpha-lipoic acid in preventing peripheral neuropathy in patients receiving chemotherapy for cancer
    • MD Anderson Cancer Center. National Library of Medicine (US), Bethesda, MD. 2000-20091219. Available from
    • MD Anderson Cancer Center (2005) Alpha-lipoic acid in preventing peripheral neuropathy in patients receiving chemotherapy for cancer. In: ClinicalTrials.gov [Internet]. National Library of Medicine (US), Bethesda, MD. 2000-20091219. Available from: http://clinicaltrials.gov/ct2/show/NCT00112996? term=neuropathy+and+chemotherapy&rank=22
    • (2005) ClinicalTrials.gov [Internet]
  • 74
    • 70449668459 scopus 로고    scopus 로고
    • Deficiency diseases of the nervous system
    • Bradley WG, Daroff RB, Fenichel GM et al (eds), 5th edn. Butterworth-Heinemann, Philadelphia
    • So YT, Simon RP (2007) Deficiency diseases of the nervous system. In: Bradley WG, Daroff RB, Fenichel GM et al (eds) Neurology in clinical practice, 5th edn. Butterworth-Heinemann, Philadelphia, pp 1643-1656
    • (2007) Neurology in Clinical Practice , pp. 1643-1656
    • So, Y.T.1    Simon, R.P.2
  • 75
    • 77952481898 scopus 로고    scopus 로고
    • Vitamina B para el tratamiento de la neuropatía periférica (Revisión Cochrane traducida)
    • Oxford. Available from (Traducida de The Cochrane Library, 2008 Issue 3. John Wiley & Sons, Ltd., Chichester, UK)
    • Ang CD, Alviar MJM, Dans AL et al (2008) Vitamina B para el tratamiento de la neuropatía periférica (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, Número 4. Update Software Ltd., Oxford. Available from: http://www.update-software.com (Traducida de The Cochrane Library, 2008 Issue 3. John Wiley & Sons, Ltd., Chichester, UK)
    • (2008) La Biblioteca Cochrane Plus , Issue.4
    • Ang, C.D.1    Alviar, M.J.M.2    Dans, A.L.3
  • 76
    • 77952472394 scopus 로고    scopus 로고
    • A randomized phase III study of vitamins B6 and B12 to prevent chemotherapy-induced neuropathy in cancer patients
    • New Mexico Cancer Care Alliance. National Library of Medicine (US), Bethesda, MD. 2000-20091222. Available from
    • New Mexico Cancer Care Alliance (2008) A randomized phase III study of vitamins B6 and B12 to prevent chemotherapy-induced neuropathy in cancer patients. In: ClinicalTrials.gov [Internet]. National Library of Medicine (US), Bethesda, MD. 2000-20091222. Available from: http://clinicaltrials.gov/ct2/show/ NCT00659269?term=neuropathy+and+chemotherapy&rank=3
    • (2008) ClinicalTrials.gov [Internet]
  • 77
    • 70449484336 scopus 로고    scopus 로고
    • Peripheral neuropathy in survivors of childhood acute lymphoblastic leukaemia
    • Ramchandren S, Leonard M, Mody RJ et al (2009) Peripheral neuropathy in survivors of childhood acute lymphoblastic leukaemia. J Periph Nerv Syst 14:184-189
    • (2009) J Periph Nerv Syst , vol.14 , pp. 184-189
    • Ramchandren, S.1    Leonard, M.2    Mody, R.J.3
  • 78
    • 0642347604 scopus 로고    scopus 로고
    • Limited access trial using amifostine for protection against cisplatin- and three-hour paclitaxel- induced neurotoxicity: A phase II study of the Gynecologic Oncology Group
    • Kore DH, Donnelly J, McGuire WP et al (2003) Limited access trial using amifostine for protection against cisplatin- and three-hour paclitaxel- induced neurotoxicity: a phase II study of the Gynecologic Oncology Group. J Clin Oncol 21:4207-4213
    • (2003) J Clin Oncol , vol.21 , pp. 4207-4213
    • Kore, D.H.1    Donnelly, J.2    McGuire, W.P.3
  • 79
    • 33845915641 scopus 로고    scopus 로고
    • Efficacy of oxcarbazepine for prophylaxis against cumulative oxaliplatin-induced neuropathy
    • Argyriou AA, Chroni E, Polychronopoulos P et al (2006) Efficacy of oxcarbazepine for prophylaxis against cumulative oxaliplatin-induced neuropathy. Neurology 67:2253-2255
    • (2006) Neurology , vol.67 , pp. 2253-2255
    • Argyriou, A.A.1    Chroni, E.2    Polychronopoulos, P.3
  • 80
    • 3042523914 scopus 로고    scopus 로고
    • Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: A retrospective study of 161 patients receiving oxaliplatin combined with 5-fluorouracil and leucovorin for advanced colorectal cancer
    • Gamelin L, Boisdron-Celle M, Delva R et al (2004) Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-fluorouracil and leucovorin for advanced colorectal cancer. Clin Cancer Res 10:4055-4061
    • (2004) Clin Cancer Res , vol.10 , pp. 4055-4061
    • Gamelin, L.1    Boisdron-Celle, M.2    Delva, R.3
  • 81
    • 33748293019 scopus 로고    scopus 로고
    • Management of oxaliplatin- induced peripheral neuropathy
    • Saif MW, Reardon J (2005) Management of oxaliplatin- induced peripheral neuropathy. Ther Clin Risk Manag 1:249-258
    • (2005) Ther Clin Risk Manag , vol.1 , pp. 249-258
    • Saif, M.W.1    Reardon, J.2
  • 82
    • 0027468106 scopus 로고
    • Reduced glutathione protects against cisplatininduced neurotoxicity in rats
    • Hamers FP, Brakkee JH, Cavalletti E et al (1993) Reduced glutathione protects against cisplatininduced neurotoxicity in rats. Cancer Res 53:544-549
    • (1993) Cancer Res , vol.53 , pp. 544-549
    • Hamers, F.P.1    Brakkee, J.H.2    Cavalletti, E.3
  • 83
    • 33750904099 scopus 로고    scopus 로고
    • Randomized double blind placebo controlled phase III study assessing the efficacy of xaliproden in reducing the cumulative peripheral sensory neuropathy induced by the oxaliplatin and 5FU/ LV combination in firstline treatment of patients with metastatic colorectal cancer
    • Abstr 229
    • Cassidy J, Bjarnason G, Hickish T et al (2006) Randomized double blind placebo controlled phase III study assessing the efficacy of xaliproden in reducing the cumulative peripheral sensory neuropathy induced by the oxaliplatin and 5FU/ LV combination in firstline treatment of patients with metastatic colorectal cancer. J Clin Oncol 24:3507. Abstr 229
    • (2006) J Clin Oncol , vol.24 , pp. 3507
    • Cassidy, J.1    Bjarnason, G.2    Hickish, T.3
  • 84
    • 49849097382 scopus 로고    scopus 로고
    • Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia
    • Traa BS, Mulholland JD, Kadam SD et al (2008) Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. Pediatr Res 64:81-85
    • (2008) Pediatr Res , vol.64 , pp. 81-85
    • Traa, B.S.1    Mulholland, J.D.2    Kadam, S.D.3
  • 85
    • 0031594875 scopus 로고    scopus 로고
    • Clinical trials of nimodipine as a potential neuroprotector in ovarian cancer patients treated with cisplatin
    • Cassidy J, Paul J, Soukop M et al (1998) Clinical trials of nimodipine as a potential neuroprotector in ovarian cancer patients treated with cisplatin. Cancer Chemother Pharamacol 41:161-166
    • (1998) Cancer Chemother Pharamacol , vol.41 , pp. 161-166
    • Cassidy, J.1    Paul, J.2    Soukop, M.3
  • 86
    • 0026543114 scopus 로고
    • LIF: Lots of interesting functions
    • Hilton DJ (1992) LIF: lots of interesting functions. Trends Biochem Sci 17:72-76
    • (1992) Trends Biochem Sci , vol.17 , pp. 72-76
    • Hilton, D.J.1
  • 87
    • 34548821005 scopus 로고    scopus 로고
    • A case of neurotoxicity reduced with goshajinkigan in modified FOLFOX6 chemotherapy for advanced colon cancer
    • Mamiya N, Kono T, Mamiya K et al (2007) A case of neurotoxicity reduced with goshajinkigan in modified FOLFOX6 chemotherapy for advanced colon cancer. Gan To Kagaku Ryoho 34:1295-1297
    • (2007) Gan to Kagaku Ryoho , vol.34 , pp. 1295-1297
    • Mamiya, N.1    Kono, T.2    Mamiya, K.3
  • 88
    • 45549104855 scopus 로고    scopus 로고
    • Reduction of oxaliplatin-related neurotoxicity
    • Shindo Y, Tenma K, Imano H et al (2008) Reduction of oxaliplatin-related neurotoxicity. Gan To Kagaku Ryoho 35:863-865
    • (2008) Gan to Kagaku Ryoho , vol.35 , pp. 863-865
    • Shindo, Y.1    Tenma, K.2    Imano, H.3
  • 89
  • 90
    • 0002482406 scopus 로고
    • Evolution and dissolution of the nervous system (Croonian Lecture)
    • Hodder and Stoughton, London
    • Jackson JH (1932) Evolution and dissolution of the nervous system (Croonian Lecture). Selected writings of John Hughlings Jackson, vol.2. Hodder and Stoughton, London
    • (1932) Selected Writings of John Hughlings Jackson , vol.2
    • Jackson, J.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.