Bench-to-bedside review: Delirium in ICU patients - importance of sleep deprivation

Critical Care

Volumn 13, Issue 6, 2009, Pages

  Weinhouse, Gerald L ^a   Schwab, Richard J ^b   Watson, Paula L ^c   Patil, Namrata ^a   Vaccaro, Bernardino ^d   Pandharipande, Pratik ^c   Ely, E Wesley ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VA BOSTON HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AMANTADINE; ANTIDEPRESSANT AGENT; AROMATIC LEVO AMINO ACID DECARBOXYLASE; BENZATROPINE; BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAMAZEPINE; CLONIDINE; COCAINE; CORTISONE ACETATE PLUS NEOMYCIN; DIGITALIS; DIPHENHYDRAMINE; DOPAMINE; HYPNOTIC AGENT; ISOFLURANE; LEVODOPA; METHYLDOPA; METHYLPHENIDATE; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PHENYTOIN; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; VALPROIC ACID;

ALCOHOLISM; ANTERIOR CINGULATE; ARTIFICIAL VENTILATION; ASSISTED VENTILATION; ATTENTION; AUDITORY HALLUCINATION; BASAL GANGLION; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN METABOLISM; BRAIN PERFUSION; COGNITIVE DEFECT; CREATIVITY; CRITICALLY ILL PATIENT; DELIRIUM; DELUSION; DEMENTIA; DEPRESSION; DISEASE ASSOCIATION; DROWSINESS; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; FATIGUE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEAD INJURY; HUMAN; HYPOXIA; INTENSIVE CARE UNIT; MOOD CHANGE; NONHUMAN; PAIN; PARANOIA; PARIETAL LOBE; PATHOPHYSIOLOGY; POSTERIOR PARIETAL CORTEX; PREFRONTAL CORTEX; PRESSURE SUPPORT VENTILATION; PRIORITY JOURNAL; PULVINAR; REM SLEEP DEPRIVATION; REVIEW; RISK FACTOR; SEPSIS; SLEEP DEPRIVATION; SLOW WAVE SLEEP; SOMNOLENCE; STRESS; SUPERIOR COLLICULUS; TASK PERFORMANCE; UNITED STATES; VISUAL HALLUCINATION; WAKEFULNESS; WORKING MEMORY; AGED; PSYCHOLOGICAL ASPECT; SYNDROME;

AGED; DELIRIUM; HUMANS; INTENSIVE CARE UNITS; RISK FACTORS; SLEEP DEPRIVATION; SYNDROME;

EID: 77951641692     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc8131     Document Type: Review

References (52)

1. Peterson JF, Pun BT, Dittus RS, Thomason JWW, Jackson JC, Shintani AK, Ely EW. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc 2006, 54:479-484. 10.1111/j.1532-5415.2005.00621.x, 16551316.
2. Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE, Inouye SK, Bernard GR, Dittus RS. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004, 291:1753-1762. 10.1001/jama.291.14.1753, 15082703.
3. Ouimet S, Kavanagh BP, Gottfried SB, Skrobik Y. Incidence, risk factors and consequences of ICU delirium. Intensive Care Med 2007, 33:66-73. 10.1007/s00134-006-0399-8, 17102966.
4. Lin S, Liu C, Wang C, Lin H, Huang C, Huang P, Fang Y, Shieh M, Kuo H. The impact of delirium on the survival of mechanically ventilated patients. Crit Care Med 2004, 32:2254-2259. 10.1097/01.CCM.0000110878.49476.42, 15640638.
5. Milbrandt EB, Deppen S, Harrison PL, Shintani AK, Speroff T, Stiles RA, Truman B, Bernard GR, Dittus RS, Ely EW. Costs associated with delirium in mechanically ventilated patients. Crit Care Med 2004, 32:955-962. 10.1097/01.CCM.0000119429.16055.92, 15071384.
6. Thomason JWW, Shintani A, Peterson JF, Pun BT, Jackson JC, Ely EW. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care 2005, 9:R375-R381. 10.1186/cc3729, 1269454, 16137350.
7. Ely EW, Gautam S, Margolin R, Francis J, May L, Speroff T, Truman B, Dittus R, Bernard R, Inouye SK. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 2001, 27:1892-1900. 10.1007/s00134-001-1132-2, 11797025.
8. Cooper AB, Thornley KS, Young GB, Slutsky AS, Stewart TE, Hanly PJ. Sleep in critically ill patients requiring mechanical ventilation. Chest 2000, 117:809-818. 10.1378/chest.117.3.809, 10713011.
9. Aurell J, Elmqvist D. Sleep in the surgical intensive care unit: continuous polygraphic recording of sleep in nine patients receiving postoperative care. Br Med J (Clin Res Ed) 1985, 290:1029-1032. 10.1136/bmj.290.6474.1029, 3921096, 1418327.
10. Freedman NS, Gazendam J, Levan L, Pack AI, Schwab RJ. Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit. Am J Respir Crit Care Med 2001, 163:451-457.
11. Gabor J, Cooper A, Crombach S, Lee B, Kadikar N, Bettger HE, Hanly PJ. Contribution of the intensive care unit environment to sleep disruption in mechanically ventilated patients and healthy subjects. Am J Respir Crit Care Med 2003, 167:708-715. 10.1164/rccm.2201090, 12598213.
12. Dinges DF, Kribbs NB. Performing while sleepy: effects of experimentally-induced sleepiness. Sleep, Sleepiness and Performance 1991, 97-128. New York: J Wiley, Monk TH.
13. Harrison Y, Horne JA. Prefrontal neuropsychological effects of sleep deprivation in young adults - a model for healthy aging?. Sleep 2000, 23:1067-73.
14. Durmer JS, Dinges DF. Neurocognitive consequences of sleep deprivation. Semin Neurol 2005, 25:117-125. 10.1055/s-2005-867080, 15798944.
15. Tyler DB. Psychological changes during experimental sleep deprivation. Dis Nerv Syst 1955, 16:293-299.
16. Mograss MA, Guillem F, Brazzini-Poisson V, Godbout R. The effects of total sleep deprivation on recognition memory processes: a study of event-related potential. Neurobiol Learn Mem 2009, 91:343-352. 19340944, 10.1016/j.nlm.2009.01.008.
17. Fisher S. The microstructure of dual-task interaction: sleep deprivation and the control of attention. Perception 1980, 9:327-337. 10.1068/p090327, 7454513.
18. Man From Mars Production: Peter Tripp Marathon. , http://man-frommars.com/tripp.html
19. Sleep Deprivation: It's More then Dark Circles Under the Eyes. , http://www.pbs.org/livelihood/nightshift/sleep_deprivation.html
20. Dement WC, Vaughan C. The Promise of Sleep 1999, New York: Delacorte Press.
21. Gulevich G, Dement W, Johnson L. Psychiatric and EEG observations on a case of prolonged (264 hours) wakefulness. Arch Gen Psychiatry 1966, 15:29-35.
22. Dorrian J, Rogers NL, Dinges DF. Psychomotor vigilance performance: neurocognitive assay sensitive to sleep loss. Sleep Deprivation: Clinical Issues, Pharmacology, and Sleep Loss Effects 2005, 193:39-70. New York: Marcel Dekker, Kushida CA.
23. Thomas M, Sing H, Belenky G, Holcomb H, Mayberg H, Dannals R, Wagner H, Thorne D, Popp K, Rowland L, Welsh A, Balwinski S, Redmond D. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res 2000, 9:335-352. 10.1046/j.1365-2869.2000.00225.x, 11123521.
24. Belenky G, Wesensten NJ, Thorne DR, Thomas ML, Sing HC, Redmond DP, Russo MB, Balkin TJ. Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. J Sleep Res 2003, 12:1-12. 10.1046/j.1365-2869.2003.00337.x, 12603781.
25. Lamond N, Jay SM, Dorrian J, Ferguson SA, Jones C, Dawson D. The dynamics of neurobehavioural recovery following sleep loss. J Sleep Res 2007, 16:33-41. 10.1111/j.1365-2869.2007.00574.x, 17309761.
26. McCusker J, Cole M, Dendukuri N, Belzile E, Primeau F. Delirium in older medical inpatients and subsequent cognitive and functional status: a prospective study. CMAJ 2001, 165:575-583. 81415, 11563209.
27. Trzepacz PT. Update on the neuropathogenesis of delirium. Dement Geriatr Cogn Disord 1999, 10:330-334. 10.1159/000017164, 10473933.
28. Trzepacz PT. Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine. Semin Clin Neuropsychiatry 2000, 5:132-148.
29. Hopkins RO, Weaver LK, Pope D, Orme JF, Bigler ED, Larson-Lohr V. Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med 1999, 160:50-56.
30. Jackson JC, Hart RP, Gordon SM, Shintani A, Truman B, May L, Ely EW. Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med 2003, 31:1226-1234. 10.1097/01.CCM.0000059996.30263.94, 12682497.
31. Mesulam MM, Waxman SG, Geschwind N, Sabin TD. Acute confusional states with right middle cerebral artery infarctions. J Neurol Neurosurg Psychiatry 1976, 39:84-89. 10.1136/jnnp.39.1.84, 492219, 1255216.
32. Koponen H, Hurri L, Stenback U, Mattila E, Soininen H, Riekkinen PJ. Computed tomography findings in delirium. J Nerv Ment Dis 1989, 177:226-231. 10.1097/00005053-198904000-00006, 2703827.
33. Bogousslavsky J, Ferranzzini M, Regli E, Assal G, Tanabe H, Delaloye-Bischof A. Manic delirium and frontal-like syndrome with paramedian infarction of right thalamus. J Neurol Neurosurg Psychiatry 1988, 51:116-119. 10.1136/jnnp.51.1.116, 1032723, 3258356.
34. Doyle M, Warden D. Use of SPECT to evaluate postcardiotomy delirium. Am J Psychiatry 1996, 153:838-839.
35. Lerner MD, Rosenstein DL. Neuroimaging in delirium and related conditions. Semin Clin Neuropsychiatry 2000, 5:98-112.
36. Drummond SPA, Brown GG, Gillin JC, Stricker JL, Wong EC, Buxton RB. Altered brain response to verbal learning following sleep deprivation. Nature 2000, 403:655-657. 10.1038/35001068, 10688201.
37. Smith ME, McEvoy LK, Gevins A. The impact of moderate sleep loss on neurophysiologic signals during working memory task performance. Sleep 2002, 25:784-789. 1626388, 12405615.
38. Benedito MAC, Camarini R. Rapid eye movement sleep deprivation induces an increase in acetylcholinesterase activity in discrete rat brain regions. Braz J Med Biol Res 2001, 34:103-109. 10.1590/S0100-879X2001000100012, 11151034.
39. Tsai LL, Bergmann BM, Perry BD, Rechtschaffen A. Effects of chronic sleep deprivation on central cholinergic receptors in rat brain. Brain Res 1994, 642:95-103. 10.1016/0006-8993(94)90909-1, 8032905.
40. Wetli CV, Mash D, Karch SB. Cocaine-associated agitated delirium and the neuroleptic malignant syndrome. Am J Emerg Med 1996, 14:425-428. 10.1016/S0735-6757(96)90066-2, 8768172.
41. Ebert D, Albert R, Hammon G, Strasser B, May A, Merz A. Eye-blink rates and depression. Is the antidepressant effect of sleep deprivation mediated by the dopamine system?. Neuropsychopharmacology 1996, 15:332-339. 10.1016/0893-133X(95)00237-8, 8887987.
42. Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006, 104:21-26. 10.1097/00000542-200601000-00005, 16394685.
43. Helton MC, Gordon SH, Nunnery SL. The correlation between sleep deprivation and the intensive care unit syndrome. Heart Lung 1980, 9:464-468.
44. Bourne RS, Mills GH. Sleep disruption in critically ill patients-pharmacologic considerations. Anesthesia 2004, 59:374-384. 10.1111/j.1365-2044.2004.03664.x, 15023109.
45. Ambrogio C, Koebnick J, Quan SF, Ranieri VM, Parthasarathy S. Assessment of sleep in ventilator-supported critically ill patients. Sleep 2008, 31:1559-1568. 2579984, 19014076.
46. Pandharipande P, Ely EW. Sedative and analgesic medications: risk factors for delirum and sleep disturbances in the critically ill. Crit Care Clin 2006, 22:313-327. 10.1016/j.ccc.2006.02.010, 16678002.
47. Marcantonio E, Ta T, Duthie E, Resnick NM. Delirium severity and psychomotor types: their relationship with outcomes after hip fracture repair. J Am Geriatr Soc 2002, 50:850-857. 10.1046/j.1532-5415.2002.50210.x, 12028171.
48. Rahkonen T, Luukkainen-Markkula R, Paanilla S, Sivenius J, Sulkava R. Delirium episode as a sign of undetected dementia among community dwelling subjects: a 2 year follow up study. J Neurol Neurosurg Psychiatry 2000, 69:519-521. 10.1136/jnnp.69.4.519, 1737142, 10990515.
49. Parthasarathy S, Tobin M. Effect of ventilator mode on sleep quality in critically ill patients. Am J Respir Crit Care Med 2002, 166:1423-1429. 10.1164/rccm.200209-999OC, 12406837.
50. Alexopoulou C, Kondili E, Vakouti E, Klimathianaki M, Prinianakis G, Georgopoulos D. Sleep during proportional-assist ventilation with load-adjustable gain factors in critically ill patients. Intensive Care Med 2007, 33:1139-1147. 10.1007/s00134-007-0630-2, 17458541.
51. Tung A, Lynch JP, Mendelson WB. Prolonged sedation with propofol in the rat does not result in sleep deprivation. Anesth Analg 2001, 92:1232-1236. 10.1097/00000539-200105000-00028, 11323352.
52. Tung A, Bergmann BM, Herrera S, Cao D, Mendelson WB. Recovery from sleep deprivation occurs during propofol anesthesia. Anesthesiology 2004, 100:1419-1426. 10.1097/00000542-200406000-00014, 15166561.