Persistent γ-herpesvirus infection induces a CD4 T cell response containing functionally distinct effector populations

Journal of Immunology

Volumn 184, Issue 7, 2010, Pages 3850-3856

  Stuller, Kathleen A ^a   Cush, Stephanie S ^a   Flaño, Emilio ^a,b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POLARITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DEGRANULATION; EFFECTOR CELL; HERPES VIRUS; LATENT VIRUS INFECTION; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; STEADY STATE; VIRUS LATENCY; VIRUS REACTIVATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CELL SEPARATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HERPES VIRUS INFECTION; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RHADINOVIRUS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CYTOTOXICITY, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HERPESVIRIDAE INFECTIONS; INTERFERON-GAMMA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; RHADINOVIRUS; T-LYMPHOCYTE SUBSETS; VIRUS LATENCY;

EID: 77951638430     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902935     Document Type: Article

References (27)

1. Foulds, K. E., C. Y. Wu, and R. A. Seder. 2006. Th1 memory: implications for vaccine development. Immunol. Rev. 211: 58-66.
2. Harari, A., V. Dutoit, C. Cellerai, P. A. Bart, R. A. Du Pasquier, and G. Pantaleo. 2006. Functional signatures of protective antiviral T-cell immunity in human virus infections. Immunol. Rev. 211: 236-254.
3. Pantaleo, G., and A. Harari. 2006. Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases. Nat. Rev. Immunol. 6: 417-423.
4. Doherty, P. C., J. P. Christensen, G. T. Belz, P. G. Stevenson, and M. Y. Sangster. 2001. Dissecting the host response to a γ-herpesvirus. Philos. Trans. R. Soc. Lond. B Biol. Sci. 356: 581-593.
5. Virgin, H. W. 2005. Immune regulation of viral infection and vice versa. Immunol. Res. 32: 293-315.
6. + T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1. J. Exp. Med. 191: 1649-1660.
7. Sparks-Thissen, R. L., D. C. Braaten, S. Kreher, S. H. Speck, and H. W. Virgin, IV. 2004. An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection. J. Virol. 78: 6827-6835.
8. + T cells. J. Exp. Med. 184: 863-871.
9. Munz, C. 2005. Immune response and evasion in the host-EBV interaction. In Epstein-Barr Virus. E. R. Robertson, ed. Caister Academic Press, Norfolk, U.K., p. 197-231.
10. Landais, E., X. Saulquin, E. Scotet, L. Trautmann, M. A. Peyrat, J. L. Yates, W. W. Kwok, M. Bonneville, and E. Houssaint. 2004. Direct killing of Epstein- Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1. Blood 103: 1408-1416. (Pubitemid 38168656)
11. Adhikary, D., U. Behrends, A. Moosmann, K. Witter, G. W. Bornkamm, and J. Mautner. 2006. Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins. J. Exp. Med. 203: 995-1006.
12. + Th1 cells kill Burkitt's lymphoma cells. J. Immunol. 169: 1593-1603 (PubMed).
13. Nikiforow, S., K. Bottomly, and G. Miller. 2001. CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation. J. Virol. 75: 3740-3752. (Pubitemid 32246383)
14. Robertson, K. A., E. J. Usherwood, and A. A. Nash. 2001. Regression of a murine gammaherpesvirus 68-positive B-cell lymphoma mediated by CD4 T lymphocytes. J. Virol. 75: 3480-3482.
15. Weck, K. E., A. J. Dal Canto, J. D. Gould, A. K. O'Guin, K. A. Roth, J. E. Saffitz, S. H. Speck, and H. W. Virgin. 1997. Murine γ-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-γ responsiveness: a new model for virus-induced vascular disease. [see comments] Nat. Med. 3: 1346-1353.
16. Steed, A. L., E. S. Barton, S. A. Tibbetts, D. L. Popkin, M. L. Lutzke, R. Rochford, and H. W. Virgin, IV. 2006. γ Interferon blocks gammaherpesvirus reactivation from latency. J. Virol. 80: 192-200.
17. + T cell-mediated control of a γ-herpesvirus in B cell-deficient mice is mediated by IFN-γ. Proc. Natl. Acad. Sci. USA 96: 5135-5140.
18. Sparks-Thissen, R. L., D. C. Braaten, K. Hildner, T. L. Murphy, K. M. Murphy, and H. W. Virgin, IV. 2005. CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNγ. Virology 338: 201-208.
19. Stuller, K. A., and E. Flaño. 2009. CD4 T cells mediate killing during persistent gammaherpesvirus 68 infection. J. Virol. 83: 4700-4703.
20. Shen, Z., G. Reznikoff, G. Dranoff, and K. L. Rock. 1997. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J. Immunol. 158: 2723-2730 (PubMed). (Pubitemid 127470530)
21. + T cells during long-term gammaherpesvirus infection. J. Virol. 75: 7744-7748.
22. Walton, S. M., P. Wyrsch, M. W. Munks, A. Zimmermann, H. Hengel, A. B. Hill, and A. Oxenius. 2008. The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection. J. Immunol. 181: 1128-1134 (PubMed).
23. Betts, M. R., and R. A. Koup. 2004. Detection of T-cell degranulation: CD107a and b. Methods Cell Biol. 75: 497-512.
24. + T cell function during viral persistence. J. Immunol. 179: 141-153 (PubMed).
25. + T cells: ready for direct attack. J. Exp. Med. 203: 805-808.
26. + T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function. J. Clin. Invest. 107: 121-130.
27. + T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers. Blood 109: 1138-1146.