Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines

Journal of Receptors and Signal Transduction

Volumn 30, Issue 3, 2010, Pages 161-169

  Hromadnikova, Ilona ^a   Volchenkov, Roman ^a   Sedlackova, Lucie ^a   Spacek, Martin ^b   Kozak, Tomas ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Acute myeloid leukemia; Cell surface expression; Gene expression; HSP70; NK cell ligands; RT PCR

Indexed keywords

HEAT SHOCK PROTEIN 70; MESSENGER RNA; NATURAL KILLER CELL RECEPTOR NKG2D;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; PRESCHOOL CHILD; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; CELL LINE, TUMOR; CELL MEMBRANE; COHORT STUDIES; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, LEUKEMIC; HL-60 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; KILLER CELLS, NATURAL; LEUKEMIA, MYELOID, ACUTE; LIGANDS; MALE; MIDDLE AGED; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K;

EID: 77951637168     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.3109/10799891003671154     Document Type: Article

References (41)

1. Calderwood SK, Teriault JR, Gong J. Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity. Eur J Immunol 2005, 35, 2518-2527.
2. Aghdassi A, Phillips P, Dudeja V, Dhaulakhandi D, Sharif R, Dawra R, Lerch MM, Saluja A. Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarci-noma. Cancer Res 2007, 67, 616-625.
3. Duval A, Olaru D, Campos L, Flandrin P, Nadal N, Guyotat D. Expression and prognostic signifcance of heat-shock proteins in myelodysplastic syndromes. Haematologica 2006, 91, 713-714.
4. Rohde M, Daugaard M, Jensen MH, Helin K, Nylandsted J, Jäättelä M. Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev 2005, 19, 570-582.
5. Ciocca DR, Vargas-Roig LM. Heat shock proteins and drug resistance in breast cancer. In: Bernal SD ed. Drug Resistance in Oncology (pp 167-190). New York: Marcel Dekker Inc., 1997.
6. Nanbu K, Konishi I, Mandai M, Kuroda H, Hamid AA, Komatsu T, Mori T. Prognostic signifcance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Cancer Detect Prev 1998, 22, 549-555.
7. Tomas X, Campos L, Mounier C, Cornillon J, Flandrin P, Le QH, Piselli S, Guyotat D. Expression of heat-shock proteins is associated with major adverse prognostic factors in acute myeloid leukemia. Leuk Res 2005, 29, 1049-1058.
8. Yeh CH, Tseng R, Zhang Z, Cortes J, O'Brien S, Giles F, Hannah A, Estrov Z, Keating M, Kantarjian H, Albitar M. Circulating heat shock protein 70 and progression in patients with chronic mye-loid leukemia. Leuk Res 2009, 33, 212-217.
9. Nimmanapalli R, O'Bryan E, Bhalla K. Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and diferentiation of Bcr-Abl-positive human leukemic blasts. Cancer Res 2001, 61, 1799-1804.
10. Guo F, Sigua C, Bali P, George P, Fiskus W, Scuto A, Annavarapu S, Mouttaki A, Sondarva G, Wei S, Wu J, Djeu J, Bhalla K. Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. Blood 2005, 105, 1246-1255.
11. Ciocca DR, Calderwood SK. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 2005, 10, 86-103.
12. Gurbuxani S, Bruey JM, Fromentin A, Larmonier N, Parcellier A, Jäättelä M, Martin F, Solary E, Garrido C. Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells. Oncogene 2001, 20, 7478-7485.
13. Vega VL, Rodríguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, Multhof G, Arispe N, De Maio A. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol 2008, 180, 4299-4307.
14. Multhof G, Botzler C, Wiesnet M, Müller E, Meier T, Wilmanns W, Issels RD. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer 1995, 61, 272-279.
15. Multhof G. Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance. Methods 2007, 43, 229-237.
16. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002, 2, 185-194. (Pubitemid 37328765)
17. Delneste Y, Magistrelli G, Gauchat J, Haeuw J, Aubry J, Nakamura K, Kawakami-Honda N, Goetsch L, Sawamura T, Bonnefoy J, Jeannin P. Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 2002, 17, 353-362.
18. Figueiredo C, Wittmann M, Wang D, Dressel R, Seltsam A, Blasczyk R, Eiz-Vesper B. Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells. Blood 2009, 113, 3008-3016.
19. Gastpar R, Gross C, Rossbacher L, Ellwart J, Riegger J, Multhof G. Te cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells. J Immunol 2004, 172, 972-980.
20. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002, 277, 15028-15034.
21. Becker T, Hartl FU, Wieland F. CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J Cell Biol 2002, 158, 1277-1285.
22. Multhof G, Mizzen L, Winchester CC, Milner CM, Wenk S, Eissner G, Kampinga HH, Laumbacher B, Johnson J. Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exp Hematol 1999, 27, 1627-1636.
23. Stangl S, Gross C, Pockley AG, Asea AA, Multhof G. Infuence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide-activated human natural killer (NK) cells. Cell Stress Chaperones 2008, 13, 221-230.
24. Elsner L, Flügge PF, Lozano J, Muppala V, Eiz-Vesper B, Demiroglu SY, Malzahn D, Herrmann T, Brunner E, Bickeböller H, Multhof G, Walter L, Dressel R. Te endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic efector functions of NK cells. J Cell Mol Med 2009.
25. Drexler HG, Dirks W, MacLeod RAF, Quentimeier H, Steube KG, Uphof CC. DSMZ catalogue of cell lines 2009: www.cell-lines.de.
26. Farkas B, Hantschel M, Magyarlaki M, Becker B, Scherer K, Landthaler M, Pfster K, Gehrmann M, Gross C, Mackensen A, Multhof G. Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and meta-static melanoma. Melanoma Res 2003, 13, 147-152.
27. Casasnovas RO, Slimane FK, Garand R, Faure GC, Campos L, Deneys V, Bernier M, Falkenrodt A, Lecalvez G, Maynadié M, Béné MC. Immunological classifcation of acute myeloblastic leukemias: relevance to patient outcome. Leukemia 2003, 17, 515-527.
28. Hromadnikova I, Sedlackova L. Analysis of cell surface and relative gene expression of heat shock protein 70 in human leukemia cell lines. Leuk Lymphoma 2008, 49, 570-576.
29. Nowbakht P, Ionescu MC, Rohner A, Kalberer CP, Rossy E, Mori L, Cosman D, De Libero G, Wodnar-Filipowicz A. Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. Blood 2005, 105, 3615-3622.
30. Pende D, Rivera P, Marcenaro S, Chang CC, Biassoni R, Conte R, Kubin M, Cosman D, Ferrone S, Moretta L, Moretta A. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res 2002, 62, 6178-6186.
31. Rohner A, Langenkamp U, Siegler U, Kalberer CP, Wodnar-Filipowicz A. Diferentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis. Leuk Res 2007, 31, 1393-1402.
32. Salih HR, Antropius H, Gieseke F, Lutz SZ, Kanz L, Rammensee HG, Steinle A. Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood 2003, 102, 1389-1396.
33. Feder JH, Rossi JM, Solomon J, Solomon N, Lindquist S. Te consequences of expressing hsp70 in Drosophila cells at normal temperatures. Genes Dev 1992, 6, 1402-1413.
34. Abravaya K, Myers MP, Murphy SP, Morimoto RI. Te human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev 1992, 6, 1153-1164.
35. Ding XZ, Tsokos GC, Kiang JG. Overexpression of HSP-70 inhibits the phosphorylation of HSF1 by activating protein phos-phatase and inhibiting protein kinase C activity. FASEB J 1998, 12, 451-459.
36. Mosser DD, Duchaine J, Massie B. Te DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70. Mol Cell Biol 1993, 13, 5427-5438.
37. Kim D, Ouyang H, Li GC. Heat shock protein hsp70 accelerates the recovery of heat-shocked mammalian cells through its modulation of heat shock transcription factor HSF1. Proc Natl Acad Sci USA 1995, 92, 2126-2130.
38. Balakrishnan K, De Maio A. Heat shock protein 70 binds its own messenger ribonucleic acid as part of a gene expression self-limiting mechanism. Cell Stress Chaperones 2006, 11, 44-50.
39. Teodorakis NG, Drujan D, De Maio A. Termotolerant cells show an attenuated expression of Hsp70 after heat shock. J Biol Chem 1999, 274, 12081-12086.
40. Zimmer J, Michel T, Andrès E, Hentges F. Up-regulation of NKG2D ligands by AML cells to increase sensitivity to NK cells: the tumour might strike back. Comment on "diferentiation-pro-moting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis" by Rohner et al. [Leuk Res 2007;31:1393-402]. Leuk Res 2008, 32, 676-677.
41. McCann FE, Eissmann P, Onfelt B, Leung R, Davis DM. Te activating NKG2D ligand class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences. J Immunol 2007, 178, 3418-3426.